Decreased E-cadherin expression is associated with haematogenous recurrence and poor prognosis in patients with squamous cell carcinoma of the oesophagus

Tamura, Shinji; Shiozaki, Hitoshi; Miyata, Masashi; Kadowaki, Takatoshi; Inoue, Masatoshi; Matsui, Shigeo; Iwazawa, Takashi; Takayama, Takuya; Takeichi, Masatoshi; Monden, Morito

doi:10.1002/bjs.1800831138

Cited by 93 publications

(47 citation statements)

References 17 publications

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“…In various cancerous tissues, a reduced expression of E-cadherin has frequently been observed in cancer progression (Katagiri et al, 1995;Lipponen and Eskelinen, 1995;Yonemura et al, 1995;Tamura et al, 1996;Nakanishi et al, 1997;Umbas et al, 1997;Bankfalvi et al, 1999;Ghadimi et al, 1999;Zheng et al, 1999;Kase et al, 2000;Gofuku et al, 1999). The aim of this study was to verify immunohistochemically the hypothesis that dysadherin, which suppresses the E-cadherin system, might play a significant role in the aggressiveness of colorectal carcinoma.…”

Section: Discussionmentioning

confidence: 96%

“…Several studies have reported that decreased function of E-cadherin is associated with tumour progression in many cancers, and in particular E-cadherin acts as a suppressor of invasive ability (Behrens et al, 1989;Vleminckx et al, 1991;Hirohashi, 2000). Many immunohistochemical studies evaluating E-cadherin expression in tumour tissues have demonstrated that reduced expression of E-cadherin is frequently observed in cancer progression (Katagiri et al, 1995;Lipponen and Eskelinen, 1995;Yonemura et al, 1995;Tamura et al, 1996;Nakanishi et al, 1997;Umbas et al, 1997;Bankfalvi et al, 1999;Ghadimi et al, 1999;Gofuku et al, 1999;Zheng et al, 1999;Kase et al, 2000).…”

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confidence: 99%

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Prognostic significance of dysadherin expression in advanced colorectal carcinoma

Aoki

Shimamura²,

Shibata³

et al. 2003

Br J Cancer

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A novel glycoprotein, dysadherin, has an anti-cell -cell adhesion function through downregulating E-cadherin. In this study, we investigated the expressions of dysadherin and E-cadherin in 82 patients with stage II and III colorectal carcinomas to determine the correlation between the two molecules and the clinicopathologic features of each tumour. Dysadherin was not expressed in normal colorectal epithelium. Fifty-one per cent of tumours showed dysadherin immunopositivity in over 50% of cancer cells. Thirty-eight per cent of tumours showed reduced E-cadherin immunopositivity. The increased expression of dysadherin was significantly associated with lung metastasis (P ¼ 0.003). The increased expression of dysadherin had a significant impact on patient survival (P ¼ 0.0099 and 0.0036, log-rank test for overall and recurrence-free survival rate, respectively). Furthermore, tumour with increased expression of dysadherin and reduced expression of E-cadherin showed the worst prognosis (P ¼ 0.0043 and 0.0028, log-rank test for overall and recurrence-free survival rate, respectively). These results suggest that increased dysadherin expression is a significant indicator of poor prognosis for patients with advanced colorectal carcinoma.

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Section: Discussionmentioning

confidence: 96%

mentioning

confidence: 99%

Prognostic significance of dysadherin expression in advanced colorectal carcinoma

Aoki

Shimamura²,

Shibata³

et al. 2003

Br J Cancer

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“…Loss of E-cadherin expression is a well-documented condition for invasiveness; [14][15][16][17][18][19][20] however, this result is debatable. 3,4 Our work demonstrated that the loss of E-cadherin itself, without a mesenchymal phenotype, may not be associated with invasive behavior, whereas tumors with a mesenchymal phenotype, regardless of E-cadherin expression, showed aggressive behavior in esophageal squamous cell carcinoma.…”

Section: Discussionmentioning

confidence: 99%

Classification of epithelial–mesenchymal transition phenotypes in esophageal squamous cell carcinoma is strongly associated with patient prognosis

2011

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Epithelial-mesenchymal transition is characterized by a loss of cell adhesion and increased cell mobility due to cells gaining a mesenchymal phenotype. During the epithelial-mesenchymal transition process, tumor cells are expected to lose their epithelial phenotype and gradually and sequentially acquire a mesenchymal phenotype. Epithelial-mesenchymal transition is a dynamic and reversible process, which has been observed in patient tissues to display a wide spectrum of phenotypes. However, very little is known about the clinical significance of the different phenotypes of the epithelial-mesenchymal transition. Based on the expression pattern of various epithelial-mesenchymal transition-related proteins, we divided 168 esophageal squamous cell carcinomas into different phenotypes, including complete type; incomplete type, including hybrid type and null type; and a wild type. The clinical significance of each phenotype was investigated. Of the 168 cases, 31 were categorized as complete type, 53 as incomplete type (hybrid type, 26 cases; null type, 27 cases), and 84 as wild type. Epithelial-mesenchymal transition phenotype was significantly associated with tumor size (P ¼ 0.021), differentiation (P ¼ 0.001), and invasion depth (Po0.001). Overall survival and disease-free survival rates were significantly worse in the complete type, better in the incomplete type, and best in the wild type. Within the incomplete type group, the hybrid type survival curve was similar to that of the complete type, whereas the overall survival of the null type was similar to the wild type. Complete type had a noticeable poorer prognostic effect on survival in patients with early invasion (pTr2) than it had on survival among patients with advanced invasion (pTZ3). The complete phenotype was an independent prognostic factor for both overall (P ¼ 0.009) and disease-free survival (Po0.001). In conclusion, classification of epithelial-mesenchymal transition phenotypes has novel clinical implications, and identification of a specific phenotype might provide a tool to better stratify and predict patient outcomes.

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“…Among the various adhesion molecules, the expression of E-cadherin has primarily been investigated, and a significant correlation between its expression and a favorable prognosis in cancer patients, including those with ESCC, has been reported (5)(6)(7).…”

Section: Introductionmentioning

confidence: 99%

Reduced expression of catenin subtypes is a potential indicator of unfavorable prognosis in esophageal squamous cell carcinoma

et al. 2009

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Abstract. Catenins are cytoplasmic proteins that play a pivotal role in cell adhesion. Conflicting results regarding the significance of their expression in esophageal squamous cell carcinoma (ESCC) have been reported. The expression of ·-, ß-and Á-catenin was examined using immunohistochemical methods in 69 samples collected from patients with ESCC who were surgically treated without any preoperative induction therapy. Reduced ·-, ß-and Á-catenin expression was observed in 48 (69.7%), 36 (52.2%) and 44 (63.8%) ESCC samples, respectively. According to univariate analysis, ESCC patients exhibiting the reduced expression of ß-catenin (P=0.028), Á-catenin (P=0.010), ·-and Á-catenin combined (P=0.047) or ß-and Á-catenin combined (P=0.046) had a significantly more unfavorable rate of survival. Multivariate analysis demonstrated that the reduced expression of Á-catenin (P=0.015) as well as lymph node metastasis (P=0.015) could serve as independent prognostic indicators of unfavorable prognosis in ESCC patients. Reduced immunohistochemical expression of Á-catenin may thus prove to be a powerfull and useful predictor of prognosis in patients with ESCC. IntroductionThe migration of cancer cells from the cancer nest is an initial event in the formation of tumor metastasis (1). Previous investigations have demonstrated that the expression of adhesion molecules, which prevent cancer cells from detaching, is a potential indicator of favorable prognosis in patients and/or of less invasive behavior in gastrointestinal cancer types, including esophageal squamous cell carcinoma (ESCC) (2-4).Among the various adhesion molecules, the expression of E-cadherin has primarily been investigated, and a significant correlation between its expression and a favorable prognosis in cancer patients, including those with ESCC, has been reported (5-7).Catenins (·-, ß-and Á-) are cytoplasmic proteins that bind to the conserved tail of the epithelial E-cadherin molecule and play a crucial role in E-cadherin-mediated intracellular signal transduction and cell adhesion. The cytoplasmic domain of E-cadherin binds to ß-or Á-catenin, while ·-catenin binds to the E-cadherin -ß-and -Á-catenin complexes to maintain the cellular cytoskeleton (8).While the immunohistochemical expression of ·-, ß-and Á-catenin in ESCC has been examined, the results reported regarding their clinicopathological significance for patient prognosis have been inconsistent (5,6,9-13). The present study used surgically dissected samples of ESCC to investigate the immunohistochemical expression of ·-, ß-and Á-catenin in order to determine their combined effect on the prognosis of patients with ESCC. Patients and methodsPatients and samples. Sixty-nine consecutive specimens of ESCC from patients surgically treated in our department between 1992 and 2003 were obtained. The study population consisted of 63 men and 6 women with a median age of 64 years (range 42-83). Preoperative induction therapy was not performed in any of the cases. Continuous follow-up of the patients was carried ou...

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Decreased E-cadherin expression is associated with haematogenous recurrence and poor prognosis in patients with squamous cell carcinoma of the oesophagus

Cited by 93 publications

References 17 publications

Prognostic significance of dysadherin expression in advanced colorectal carcinoma

Prognostic significance of dysadherin expression in advanced colorectal carcinoma

Classification of epithelial–mesenchymal transition phenotypes in esophageal squamous cell carcinoma is strongly associated with patient prognosis

Reduced expression of catenin subtypes is a potential indicator of unfavorable prognosis in esophageal squamous cell carcinoma

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