Decreased dopaminergic treatment of hospitalized Parkinson’s disease patients during infectious diseases is associated with poor outcomes

Segal, Omer; Hassin‐Baer, Sharon; Rosman, Maya; Segal, Gad

doi:10.1016/j.jocn.2015.02.010

Cited by 4 publications

(4 citation statements)

References 8 publications

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“…The present study expands the current literature regarding prognostic factors associated with PD patients' deterioration and survival. It further reinforces the findings of a previous, smaller cohort analysis published earlier [5]. Decreased dopaminergic treatment was found to be a widespread phenomenon during PD patients' hospitalizations, occurring in more than half of the population (50.7%).…”

supporting

confidence: 89%

“…The investigators of this study hypothesized that patients with PD might have worse prognosis when hospitalized due to infections due to dopaminergic treatment under-dose. These assumptions were confirmed in a previous analysis of a smaller cohort [5]. The main clinical outcomes were in-hospital mortality and worse discharge destination after hospitalizations (defined as worse in any case that the patient arrived from home and was discharged to a nursing home, rehabilitation facility, or was referred to chronic hospitalization).…”

supporting

confidence: 57%

“…This was a follow-up, retrospective study of consecutive PD patients diagnosed with either pneumonia, UTI, or both and hospitalized to internal medicine departments (IMD) in one large tertiary medical center through 2008-2013. The follow-up study doubled the patient population included in a previous publication [5]. All the data collected for this study was originally documented in the electronic medical record on patient's admission, compiled into an electronic sheet and was analyzed by SAS (Ver.…”

mentioning

confidence: 99%

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Decreased Anti‐Parkinson's Therapy during Hospitalization due to Infectious Diseases is Associated with Worse Prognosis

et al. 2016

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supporting

confidence: 89%

supporting

confidence: 57%

mentioning

confidence: 99%

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Decreased Anti‐Parkinson's Therapy during Hospitalization due to Infectious Diseases is Associated with Worse Prognosis

et al. 2016

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“…The dose of LED increased during hospitalization, although the change did not reach statistical significance. A recent report suggested that a reduction in LED during hospitalization was significantly associated with increased in-hospital mortality and worse discharge destination [10] . Thus, reduced LED could potentially worsen motor disability at discharge, leading to increasing costs for patients' care.…”

Section: Discussionmentioning

confidence: 99%

Hospital-based study on emergency admission of patients with Parkinson's disease

et al. 2016

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ObjectiveParkinson's disease (PD) is a progressive neurodegenerative disease. As the severity of disease worsens, patients have lower tolerance for treatments and occasionally need to be hospitalized. This study focuses on characteristics of patients with PD who were emergently admitted to our hospital and evaluates their prognosis during hospitalization.MethodsHospital-based study on emergency admission was conducted in a consecutive series of patients with PD between April 2009 and March 2015.ResultsA total of 164 admissions involving 136 patients with PD with available medical records were identified. Among these, 40 admissions involving 38 patients were emergency admissions. The most common cause of hospitalization was aspiration pneumonia (n = 17) followed by parkinsonism hyperpyrexia syndrome (n = 6), cerebrovascular disease (n = 2), dehydration (n = 2), and others (n = 13). The mean Hoehn and Yahr stage at admission and discharge were 3.5 and 4.2, respectively, with significant differences between time points (p < 0.001). All patients except one presented with either postural instability gait difficulty phenotype (PIGD) or mixed phenotype with PIGD and tremor. All 17 patients with aspiration pneumonia had various combinations of three components: abnormalities seen on videofluoroscopy swallowing study, cognitive impairment, and history of psychiatric symptoms.ConclusionAspiration pneumonia was the most common reason for emergency admission in patients afflicted with PD for more than five years. Abnormalities seen in videofluoroscopy, PIGD and mixed phenotypes, cognitive impairment, and history of psychiatric symptoms could potentially be predictors for aspiration pneumonia in patients with PD.

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VI. Emergency and Perioperative Management of the Parkinson's Disease Patients

Tsuboi

Fujioka

2015

J. Jpn. Soc. Intern. Med

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Decreased dopaminergic treatment of hospitalized Parkinson’s disease patients during infectious diseases is associated with poor outcomes

Cited by 4 publications

References 8 publications

Decreased Anti‐Parkinson's Therapy during Hospitalization due to Infectious Diseases is Associated with Worse Prognosis

Decreased Anti‐Parkinson's Therapy during Hospitalization due to Infectious Diseases is Associated with Worse Prognosis

Hospital-based study on emergency admission of patients with Parkinson's disease

VI. Emergency and Perioperative Management of the Parkinson's Disease Patients

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