Decreased dopamine transporter availability in male smokers — A dual isotope SPECT study

Yang, Yen Kuang; Yao, Wei Jen; Yeh, Tzung Lieh; Lee, I Hui; Chen, Po See; Lu, Ru Band; Chiu, Nan Tsing

doi:10.1016/j.pnpbp.2007.08.018

Cited by 76 publications

(59 citation statements)

References 37 publications

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“…In line with the finding in the present study consistent changes in DAT availability in smokers have not been demonstrated (28)(29)(30), and recently, we failed to demonstrate significant changes in the DAT availability in a European multicenter study of 26 active smokers (the effect of both constitutive features and chronic exposure to nicotine) and 48 exsmokers (the effect of constitutive features) compared to 65 nonsmokers (31). In contrast to the findings in nicotine abuse, several studies have demonstrated a reduced DAT availability in subjects both actively abusing methamphetamine and in subjects detoxified for months (32,33).…”

Section: Discussionsupporting

confidence: 88%

No correlation between body mass index and striatal dopamine transporter availability in healthy volunteers using SPECT and [¹²³I]PE2I

Thomsen

Ziebell

Jensen

et al. 2013

Obesity

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Objective: Dopamine plays an important role in both the rewarding and conditioning effects of food. These effects involve mesolimbic, mesocortical, and nigrostriatal pathways. In humans, the most consistent finding has been reduced striatal dopamine D 2/3 receptor availability. In striatum, dopamine is inactivated by reuptake via the dopamine transporter (DAT). The aim of the study was to test the hypothesis of lower DAT availability in obese healthy subjects using a selective DAT radiotracer in a sample of subjects with a wide range of BMI values. Design and Methods: Thirty-three healthy subjects with a mean age of 48.4 6 13.3 (range, 21-71) years and a mean BMI of 29.6 6 7.8 kg/m 2 (range, 21.0-49.5) were included in the study. We used [123 I]PE2I and SPECT to measure DAT availability. Results: Using multiple linear regression analyses with striatal DAT as the dependent variable and BMI, age and gender as predictors was performed. We found no correlation between BMI and striatal DAT availability in striatum (P ¼ 0.99), caudate nucleus (P ¼ 0.61), and putamen (P ¼ 0.30). Furthermore, we found no group difference between obese/severely obese (BMI > 30 kg/m 2 ) and normal weight controls (BMI 25 kg/m 2 ). Conclusions: We did not find any correlation between BMI and DAT availability in healthy volunteers.

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Section: Discussionsupporting

confidence: 88%

No correlation between body mass index and striatal dopamine transporter availability in healthy volunteers using SPECT and [¹²³I]PE2I

Thomsen

Ziebell

Jensen

et al. 2013

Obesity

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“…To acquire an understanding of the DAT and SERT availabilities in the heroin users, multiple comparisons with Bonferroni correction were conducted to probe the effect of methadone-free abstinence. Multiple regressions were applied to examine the effect of group difference after controlling potential confounders, including age, sex, and tobacco use (Yang et al 2008a). As DAT and SERT availabilities are associated with depression (Newberg et al 2005;Yang et al 2008b), regression models including the TDQ as a predictor while controlling the effect of age (Hesse et al 2003) were also conducted.…”

Section: Discussionmentioning

confidence: 99%

Availability of dopamine and serotonin transporters in opioid-dependent users—a two-isotope SPECT study

et al. 2011

Self Cite

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“…Moreover, at least in cocaine addiction, this reduction in receptor radiotracer binding has been shown to result from the decreased expression of postsynaptic dopamine D2/3 receptors, rather than to higher synaptic dopamine concentrations that would compete with the radio-tracer 49 . In nicotine addiction, two related studies have reported lower striatal dopamine receptor availability in male but not female cigarette smokers 65,66 and three studies have found no differences in receptor availability between individuals who smoke and healthy nonsmokers irrespective of gender [67][68][69] . There is no evidence of changes in striatal dopamine receptor availability in cannabis addiction [70][71][72][73][74] , and we could not find any published studies on such changes in ecstasy or ketamine users.…”

Section: Lower Dopamine Function?mentioning

confidence: 99%

The dopamine theory of addiction: 40 years of highs and lows

et al. 2015

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Addiction has for several decades come to be viewed as a disorder of the dopamine neurotransmitter system; however, this view has not led to new treatments. We review the origins of the dopamine theory of addiction and discuss the ability of addictive drugs to elicit the release dopamine in the human striatum. There is robust evidence that stimulants increase striatal dopamine release, some evidence for alcohol, but little if any for cannabis and opiates. Moreover, there is good evidence that striatal dopamine receptor availability and dopamine release are diminished in individuals with stimulant or alcohol dependence but not in individuals with opiate, nicotine or cannabis dependence. These observations have implications for understanding reward and treatment responses in various addictions.

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Decreased dopamine transporter availability in male smokers — A dual isotope SPECT study

Cited by 76 publications

References 37 publications

No correlation between body mass index and striatal dopamine transporter availability in healthy volunteers using SPECT and [¹²³I]PE2I

No correlation between body mass index and striatal dopamine transporter availability in healthy volunteers using SPECT and [¹²³I]PE2I

Availability of dopamine and serotonin transporters in opioid-dependent users—a two-isotope SPECT study

The dopamine theory of addiction: 40 years of highs and lows

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Decreased dopamine transporter availability in male smokers — A dual isotope SPECT study

Cited by 76 publications

References 37 publications

No correlation between body mass index and striatal dopamine transporter availability in healthy volunteers using SPECT and [123I]PE2I

No correlation between body mass index and striatal dopamine transporter availability in healthy volunteers using SPECT and [123I]PE2I

Availability of dopamine and serotonin transporters in opioid-dependent users—a two-isotope SPECT study

The dopamine theory of addiction: 40 years of highs and lows

Contact Info

Product

Resources

About

No correlation between body mass index and striatal dopamine transporter availability in healthy volunteers using SPECT and [¹²³I]PE2I

No correlation between body mass index and striatal dopamine transporter availability in healthy volunteers using SPECT and [¹²³I]PE2I