Decreased diversity of nasal microbiota and their secreted extracellular vesicles in patients with chronic rhinosinusitis based on a metagenomic analysis

Choi, Eunjeong; Hong, Sung Wook; Kim, D.-K.; Jeon, Seong Gyu; Kim, K.-R.; Cho, S.-H.; Gho, Yong Song; Jee, Young Koo; Kim, Y.-K.

doi:10.1111/all.12374

Cited by 131 publications

(149 citation statements)

References 32 publications

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“…In this study, CRS patients exhibited more bacterial abundance but less diversity in nasal lavage specimens. 447 In a large cohort of patients, Ramakrishnan et al 445 examined microbiome alterations by phenotype and noted that CRS patients with asthma or purulence had markedly different microbiota. In this study, the…”

Section: S55mentioning

confidence: 99%

International Consensus Statement on Allergy and Rhinology: Rhinosinusitis

Orlandi

Kingdom

Hwang

et al. 2016

Int Forum Allergy Rhinol

554

888

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Background:The body of knowledge regarding rhinosinusitis (RS) continues to expand, with rapid growth in number of publications, yet substantial variability in the quality of those presentations. In an effort to both consolidate and critically appraise this information, rhinologic experts from around the world have produced the International Consensus Statement on Allergy and Rhinology: Rhinosinusitis (ICAR:RS). Methods:Evidence-based reviews with recommendations (EBRRs) were developed for scores of topics, using previously reported methodology. Where existing evidence was insufficient for an EBRR, an evidence-based review (EBR) was produced. The sections were then synthesized and the entire manuscript was then reviewed by all authors for consensus. Results:The resulting ICAR:RS document addresses multiple topics in RS, including acute RS (ARS), chronic RS (CRS) with and without nasal polyps (CRSwNP and CRSsNP), recurrent acute RS (RARS), acute exacerbation of CRS (AE-CRS), and pediatric RS. Conclusion:As a critical review of the RS literature, ICAR:RS provides a thorough review of pathophysiology and evidence-based recommendations for medical and surgical treatment. It also demonstrates the significant gaps in our understanding of the pathophysiology and optimal management of RS. Too o en the foundation upon which these recommendations are based is comprised of lowerlevel evidence. It is our hope that this summary of the evidence in RS will point out where additional research efforts may be directed. C 2016 ARS-AAOA, LLC. Key Words:rhinosinusitis; chronic rhinosinusitis; acute rhinosinusitis; recurrent acute rhinosinusitis; evidence-based medicine; systematic review; endoscopic sinus surgery List of Abbreviations Used

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Section: S55mentioning

confidence: 99%

International Consensus Statement on Allergy and Rhinology: Rhinosinusitis

Orlandi

Kingdom

Hwang

et al. 2016

Int Forum Allergy Rhinol

554

888

View full text Add to dashboard Cite

show abstract

“…Boase et al 9 and Choi et al 11 found an increased bacterial load in CRS patients and suggested that a rise in bacteria, possibly from external sources, causes CRS. However, Abreu et al, 10 , Feazel et al 12 and Ramakrishnan et al 13 found no difference in burden between the two groups.…”

Section: Bacterial Loadmentioning

confidence: 99%

“…Traditional culture-dependent methods fail to truly represent the sinus microbiome 9,15 , so truly accurate insights into CRS versus healthy microbiomes are from a currently limited number of molecular-based studies [9][10][11][12][15][16][17][18] .…”

Section: Crs and The Sinus Microbiomementioning

confidence: 99%

“…Of particular importance to CRS is S. aureus. Most microbiome studies found that S. aureus was enriched in CRS patients; some even found it to be the most abundant organism in CRS sinuses 9,11,12,16,18 . Here it is important Figure 1.…”

Section: Balance Of Bacterial Taxamentioning

confidence: 99%

“…The bacterial taxa presented here are a few of the commensal and pathogenic species that have been implicated in CRS disease progression. This figure is adapted from the information in the following references 5,6,[8][9][10][11][12][13][14][15][16] .…”

Section: Balance Of Bacterial Taxamentioning

confidence: 99%

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Chronic rhinosinusitis: a microbiome in dysbiosis and the search for alternative treatment options

et al. 2016

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Chronic rhinosinusitis (CRS) is a common chronic disease. While CRS is a multifactorial disease, many cases involve an imbalance in the sinus bacterial microbiome. This article reviews the composition of the healthy human sinus microbiome compared to the microbiome of CRS patients. Issues with current treatment options, particularly antibiotics, are discussed. Insights into the future of CRS treatment are also explored, principally with regards to probiotics.

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Composition and immunological significance of the upper respiratory tract microbiota

2016

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The intestinal microbiota is essential for nutrient acquisition, immune development, and exclusion of invading pathogens. The upper respiratory tract (URT) microbiota is less well studied and does not appear to abide by many of the paradigms of the gastrointestinal tract. Decades of carriage studies in children have demonstrated that microbe-microbe competition and collusion occurs in the URT. Whether colonization with common pathogens (e.g., Staphylococcus aureus and Streptococcus pneumoniae) alters immune development or susceptibility to respiratory conditions is just beginning to be understood. Herein, we discuss the biogeography of the URT microbiota, the succession and evolution of the microbiota through the life course, and discuss the evidence for microbe-microbe interactions in colonization and infection.

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Decreased diversity of nasal microbiota and their secreted extracellular vesicles in patients with chronic rhinosinusitis based on a metagenomic analysis

Abstract: These results suggest that patients with CRS have altered nasal microbiota and decreased diversity in bacterial compositions as well as increased S. aureus abundance in those patients with polyps.

Cited by 131 publications

References 32 publications

International Consensus Statement on Allergy and Rhinology: Rhinosinusitis

International Consensus Statement on Allergy and Rhinology: Rhinosinusitis

Chronic rhinosinusitis: a microbiome in dysbiosis and the search for alternative treatment options

Composition and immunological significance of the upper respiratory tract microbiota

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