Decreased colonization of chicks by Salmonella enterica serovar Gallinarum expressing mannose-sensitive FimH adhesin from Salmonella enterica serovar Enteritidis

Kuźmińska-Bajor, Marta; Kuczkowski, Maciej; Grzymajło, Krzysztof; Wojciech, Łukasz; Sabat, Maryana; Kisiela, Dagmara I.; Wieliczko, Alina; Ugorski, Maciej

doi:10.1016/j.vetmic.2012.01.029

Cited by 20 publications

(28 citation statements)

References 29 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The Salmonella plasmid virulence (spv) locus is a highly conserved sequence commonly carried by all pathogenic Salmonella. It can increase the growth of Salmonella in extraintestinal tissue cells, and is associated with bacterial serum resistance, adhesion, and colonization (Kuźmińska-Bajor et al, 2012). The spv region contains five genes: spvR, spvA, spvB, spvC, and spvD.…”

Section: The Escape Mechanism Employed By Salmonella To Evade Host Cementioning

confidence: 99%

Salmonella Interacts With Autophagy to Offense or Defense

Shen

Zhang

et al. 2020

Front. Microbiol.

View full text Add to dashboard Cite

Autophagy is an important component of the innate immune system in mammals. Low levels of basic autophagy are sustained in normal cells, to help with the clearance of aging organelles and misfolded proteins, thus maintaining their structural and functional stability. However, when cells are faced with challenges, such as starvation or pathogenic infection, their level of autophagy increases significantly. Salmonella is a facultative intracellular pathogen, which imposes an economic burden on the poultry farming industry and human public health. Previous studies have shown that Salmonella can induce the autophagy of cells following invasion, which to a certain extent helps to protect the cells from bacterial colonization. This review summarizes the latest research in the field of Salmonella-induced autophagy, including: (i) the autophagy induction and escape mechanisms employed by Salmonella during the infection of host cells; (ii) the effect of autophagy on intracellular Salmonella; (iii) the important autophagy adaptors that recognize intracellular Salmonella in host cells; and (iv) the effect of autophagy-modulating drugs on Salmonella infection.

show abstract

Section: The Escape Mechanism Employed By Salmonella To Evade Host Cementioning

confidence: 99%

Salmonella Interacts With Autophagy to Offense or Defense

Shen

Zhang

et al. 2020

Front. Microbiol.

View full text Add to dashboard Cite

show abstract

“…Typhimurium [ 7 ]. Additional fimbrial operons found in other Salmonella serovars [ 8 ] or single nucleotide polymorphisms found within the same fimbrial genes present in different serovars [ 9 ] may further affect their adhesion to the chicken gut epithelium.…”

Section: Early Events Following Salmonella Infementioning

confidence: 99%

Gene expression in the chicken caecum in response to infections with non-typhoid Salmonella

Rychlı́k

Elsheimer-Matulova

Kýrová

2014

Vet Res

View full text Add to dashboard Cite

Chickens can be infected with Salmonella enterica at any time during their life. However, infections within the first hours and days of their life are epidemiologically the most important, as newly hatched chickens are highly sensitive to Salmonella infection. Salmonella is initially recognized in the chicken caecum by TLR receptors and this recognition is followed by induction of chemokines, cytokines and many effector genes. This results in infiltration of heterophils, macrophages, B- and T-lymphocytes and changes in total gene expression in the caecal lamina propria. The highest induction in expression is observed for matrix metalloproteinase 7 (MMP7). Expression of this gene is increased in the chicken caecum over 4000 fold during the first 10 days after the infection of newly hatched chickens. Additional highly inducible genes in the caecum following S. Enteritidis infection include immune responsive gene 1 (IRG1), serum amyloid A (SAA), extracellular fatty acid binding protein (ExFABP), serine protease inhibitor (SERPINB10), trappin 6-like (TRAP6), calprotectin (MRP126), mitochondrial ES1 protein homolog (ES1), interferon-induced protein with tetratricopeptide repeats 5 (IFIT5), avidin (AVD) and transglutaminase 4 (TGM4). The induction of expression of these proteins exceeds a factor of 50. Similar induction rates are also observed for chemokines and cytokines such as IL1β, IL6, IL8, IL17, IL18, IL22, IFNγ, AH221 or iNOS. Once the infection is under control, which happens approx. 2 weeks after infection, expression of IgY and IgA increases to facilitate Salmonella elimination from the gut lumen. This review outlines the function of individual proteins expressed in chickens after infection with non-typhoid Salmonella serovars.

show abstract

“…Notably, FimH of serovar Gallinarum and Typhimurium differ by only 5–6 amino acids, but one amino acid substitution was sufficient to restore mannose-specific binding (Kisiela et al, 2005). Moreover, the mannose-inhibitable FimH of serovar Enteritidis which has the latter amino acid substitution, decreased chick colonization when studied in serovar Gallinarum (Kuzminska-Bajor et al, 2012). Together, these data demonstrated that allelic variation of the Salmonella FimH adhesin directs not only host-cell-specific recognition, but also distinctive binding to mammalian or avian receptors.…”

Section: Salmonella Ligand Alleles: the Devil Is In The Detailsmentioning

confidence: 99%

“…We predict that host-dependent colonization is not only modulated by specific adhesin alleles (Guo et al, 2009; Kuzminska-Bajor et al, 2012), but also by non-synonymous SNPs in additional virulence factors, such as the T3SS effectors (Schlumberger et al, 2003; Hopkins and Threlfall, 2004; Raffatellu et al, 2005; Thornbrough and Worley, 2012). It is also likely that numerous additional Salmonella protein alleles will be identified in the near future as virulence factors senso lato, including proteins of metabolic pathways that have evolved to take advantage of unique host species properties.…”

Section: Snps Snapshot: Salmonella Et Almentioning

confidence: 99%

Allelic variation in Salmonella: an underappreciated driver of adaptation and virulence

Yue

Schifferli

2014

Front. Microbiol.

View full text Add to dashboard Cite

Salmonella enterica causes substantial morbidity and mortality in humans and animals. Infection and intestinal colonization by S. enterica require virulence factors that mediate bacterial binding and invasion of enterocytes and innate immune cells. Some S. enterica colonization factors and their alleles are host restricted, suggesting a potential role in regulation of host specificity. Recent data also suggest that colonization factors promote horizontal gene transfer of antimicrobial resistance genes by increasing the local density of Salmonella in colonized intestines. Although a profusion of genes are involved in Salmonella pathogenesis, the relative importance of their allelic variation has only been studied intensely in the type 1 fimbrial adhesin FimH. Although other Salmonella virulence factors demonstrate allelic variation, their association with specific metadata (e.g., host species, disease or carrier state, time and geographic place of isolation, antibiotic resistance profile, etc.) remains to be interrogated. To date, genome-wide association studies (GWAS) in bacteriology have been limited by the paucity of relevant metadata. In addition, due to the many variables amid metadata categories, a very large number of strains must be assessed to attain statistically significant results. However, targeted approaches in which genes of interest (e.g., virulence factors) are specifically sequenced alleviates the time-consuming and costly statistical GWAS analysis and increases statistical power, as larger numbers of strains can be screened for non-synonymous single nucleotide polymorphisms (SNPs) that are associated with available metadata. Congruence of specific allelic variants with specific metadata from strains that have a relevant clinical and epidemiological history will help to prioritize functional wet-lab and animal studies aimed at determining cause-effect relationships. Such an approach should be applicable to other pathogens that are being collected in well-curated repositories.

show abstract

Decreased colonization of chicks by Salmonella enterica serovar Gallinarum expressing mannose-sensitive FimH adhesin from Salmonella enterica serovar Enteritidis

Cited by 20 publications

References 29 publications

Salmonella Interacts With Autophagy to Offense or Defense

Salmonella Interacts With Autophagy to Offense or Defense

Gene expression in the chicken caecum in response to infections with non-typhoid Salmonella

Allelic variation in Salmonella: an underappreciated driver of adaptation and virulence

Contact Info

Product

Resources

About