Decreased colonic mucus in rats with loperamide-induced constipation

Effects of Yogurt Supplemented with Brewer's Yeast Cell Wall on Constipation and Intestinal Microflora in Rats.

“…However, there were no significant differences on the fecal water content and the concentration of each cecal SCFA among groups. The drop in fecal water content in control rats with constipation (Table 5) was not as low as that in a previous study using loperamide (about 60%) (19). This indicated that constipation was not fully induced in the present study.…”

Ameliorative Effect of <i>Lecaniodiscus cupanioides</i> (Sapindaceae) Aqueous Root Extract in Loperamide- Induced Constipated Rats

“…This observation was also reported in previous studies [16]. However, loperamide did not prevent the animals from feeding adequately [11].…”

Improved annotation of conjugated bile acid hydrolase superfamily members in Gram-positive bacteria

“…Bile salt deconjugation is the obligatory first reaction in further oxidation and dehydroxylation steps of bile salts by intestinal bacteria, and it includes the production of secondary bile salts that have been linked to various intestinal diseases, such as the formation of gallstones and colon cancer (Ridlon et al, 2006). Moreover, results of in vitro studies have suggested that bile salt deconjugation plays a role in mucin production and excretion in the intestinal lumen (Klinkspoor et al, 1999), and this could affect the nutritional environment encountered by the intestinal microbiota, and intestinal transit time (Shimotoyodome et al, 2000).…”