Decreased Cognitive Functioning After Electroconvulsive Therapy Is Related to Increased Hippocampal Volume

Oostrom, Iris van; Eijndhoven, Philip van; Butterbrod, Elke; Beek, Maria H van; Janzing, J.G.E.; Donders, Rogier; Schene, Aart H.; Tendolkar, Indira

doi:10.1097/yct.0000000000000483

Cited by 46 publications

(36 citation statements)

References 47 publications

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“…Our results support the findings of Van Oostrom et al , however, meta‐analyses and reviews , do not share the same conclusion on the link between regional volume changes and cognitive functioning related to ECT. The distinct characteristics between our study and the studies described in the meta‐analyses could have led to these opposing conclusions.…”

Section: Discussionsupporting

confidence: 61%

“…Furthermore, the MMSE’s value is under debate , and its susceptibility to learning effects remind us to be careful with respect to the findings related to the MMSE. Also, an immediate posttreatment cognitive assessment would have allowed us to make a more profound claim about the influence of HV on change in memory performance during ECT, as was the case in the study by Van Oostrom et al . The assessment of memory performance at T2 introduces another limitation.…”

Section: Discussionmentioning

confidence: 99%

“…Finally, both are related to the frequency of the ECT‐sessions , . In a recent study, in 19 patients with treatment resistant depression with an average age of 49.7 years, it was suggested that a transient increase in HV after an ECT‐course was related to transient cognitive side‐effects .…”

Section: Introductionmentioning

confidence: 99%

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Association between hippocampal volume change and change in memory following electroconvulsive therapy in late‐life depression

Laroy

Bouckaert

Vansteelandt

et al. 2019

Acta Psychiatr Scand

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Laroy M, Bouckaert F, Vansteelandt K, et al. Association between hippocampal volume change and change in memory following electroconvulsive therapy in late-life depression.Objective: Electroconvulsive therapy (ECT)-induced hippocampal volume change (HVC) has been repeatedly described in recent years. The similar time course of HVC and ECT-related cognitive effects suggest a relation, that is to date, understudied. This study investigates whether HVC following ECT predicts the change in memory performance six months after the end of the ECT treatment. Methods: Hippocampal volume (HV) was measured via high-resolution 3D T1weighted images in 88 patients with late-life depression, within 1 week before and after ECT. Memory performance was assessed before and six months after ECT. Multiple linear regression was used to examine whether change in memory performance could be predicted based on ECT-induced changes in HV. Results: Larger right absolute HVC predicts less pronounced improvement on the VAT (visual memory) in the whole sample. For the 8-Word Test (verbal memory), Category Fluency Test (semantic memory), and MMSE, the effect is only present in patients who switched from right unilateral to bitemporal stimulation after six ECT sessions. Absolute HVC in the left hemisphere was not significantly related to cognitive change. Conclusion: A larger absolute change in right HV during ECT is associated with less improvement in memory performance up to 6 months post-ECT.

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Section: Discussionsupporting

confidence: 61%

Section: Discussionmentioning

confidence: 99%

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Association between hippocampal volume change and change in memory following electroconvulsive therapy in late‐life depression

Laroy

Bouckaert

Vansteelandt

et al. 2019

Acta Psychiatr Scand

View full text Add to dashboard Cite

show abstract

“…Extensive hippocampal remodeling is one possible hypothesis of ECT-mediated cognitive impairment (Akers et al, 2014). Consistent with this hypothesis, a recent study demonstrated that increased hippocampal volume was related to decreased cognitive performance (van Oostrom et al, 2018). In contrast, our results demonstrate that ECT responsive brain networks had no contribution to memory impairment from multimodal and network perspectives.…”

Section: Discussionsupporting

confidence: 87%

“…These results suggest that the efficacy of ECT is unexplained by hippocampal enlargement or single gray matter modality, which alone might not serve as a viable biomarker for treatment outcomes (Zhuo & Yu, ). Furthermore, pretranslational (Akers et al, ) and translational (van Oostrom et al, ) investigations have demonstrated an association between hippocampal neuroplasticity and cognitive impairment. However, the focus on a specific brain region or single imaging modality may limit discovery of structural and functional brain changes in the whole point view that are related to clinical outcomes.…”

Section: Introductionmentioning

confidence: 99%

Electroconvulsive therapy treatment responsive multimodal brain networks

Abbott

Narr

et al. 2020

Human Brain Mapping

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Electroconvulsive therapy is regarded as the most effective antidepressant treatment for severe and treatment‐resistant depressive episodes. Despite the efficacy of electroconvulsive therapy, the neurobiological underpinnings and mechanisms underlying electroconvulsive therapy induced antidepressant effects remain unclear. The objective of this investigation was to identify electroconvulsive therapy treatment responsive multimodal biomarkers with the 17‐item Hamilton Depression Rating Scale guided brain structure–function fusion in 118 patients with depressive episodes and 60 healthy controls. Results show that reduced fractional amplitude of low frequency fluctuations in the prefrontal cortex, insula and hippocampus, linked with increased gray matter volume in anterior cingulate, medial temporal cortex, insula, thalamus, caudate and hippocampus represent electroconvulsive therapy responsive covarying functional and structural brain networks. In addition, relative to nonresponders, responder‐specific electroconvulsive therapy related brain networks occur in frontal‐limbic network and are associated with successful therapeutic outcomes. Finally, electroconvulsive therapy responsive brain networks were unrelated to verbal declarative memory. Using a data‐driven, supervised‐learning method, we demonstrated that electroconvulsive therapy produces a remodeling of brain functional and structural covariance that was unique to antidepressant symptom response, but not linked to memory impairment.

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Anterior cingulate gamma‐aminobutyric acid concentrations and electroconvulsive therapy

et al. 2020

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Decreased Cognitive Functioning After Electroconvulsive Therapy Is Related to Increased Hippocampal Volume

Abstract: Our findings tentatively suggest that the temporal increase in hippocampal volume after treatment, which may result from neurotrophic processes and is thought to be crucial for the antidepressive effect, is also related to the temporary cognitive side effects of ECT.

Cited by 46 publications

References 47 publications

Association between hippocampal volume change and change in memory following electroconvulsive therapy in late‐life depression

Association between hippocampal volume change and change in memory following electroconvulsive therapy in late‐life depression

Electroconvulsive therapy treatment responsive multimodal brain networks

Anterior cingulate gamma‐aminobutyric acid concentrations and electroconvulsive therapy

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