Decreased cocaine demand following contingency management treatment

Yoon, Jin Ho; Suchting, Robert; Dios, Constanza de; Vincent, Jessica; McKay, Sarah A.; Lane, Scott D.; Schmitz, Joy M.

doi:10.1016/j.drugalcdep.2021.108883

Cited by 12 publications

(12 citation statements)

References 74 publications

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“…Accounting for inflation, it may be more appropriate to have the initial value of the incentive in the escalating and resetting group be $7, or $2,775 total earnings in the High Paying Group to produce similar results (28% decrease in the value of $1 since 2007; US Bureau of Labor Statistics). This increase in payment is supported by other studies, such as Yoon et al (2021), who describe a high magnitude CM arrangement in which participants earned $10 for providing their first benzoylecgonine‐negative sample. This warrants further consideration of the initial incentive value when using an escalating and resetting schedule.…”

Section: Discussionsupporting

confidence: 70%

A preliminary investigation of schedule parameters on cocaine abstinence in contingency management

Regnier

Strickland²,

Stoops

2022

J Exper Analysis Behavior

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Contingency management (CM) interventions are the most effective psychosocial interventions for substance use disorders. However, further investigation is needed to create the most robust intervention possible. This study investigated the effects of 1) reinforcer magnitude; and 2) fixed and escalating and resetting incentives on cocaine abstinence in an outpatient trial. In this analysis, 34 treatment-seeking individuals with Cocaine Use Disorder received either high or low value incentives for providing a benzoylecgonine-negative urine sample or were in a control condition and received incentives for providing a urine sample regardless of the results. Participants received either escalating and resetting incentives, wherein the value of each incentive increased with consecutive negative samples and reset to the initial level upon a positive sample (Experiment 1), or fixed incentives, wherein they received the same value incentive for each negative urine sample they provided (Experiment 2). Large incentives produced more abstinence, although escalating and resetting reinforcer values did not have a differential effect. Large, fixed incentives promoted abstinence faster than other reinforcers, whereas smaller incentives resulted in poor abstinence and took many visits to achieve initial abstinence. Future research comparing different schedules on cocaine abstinence in a randomized control trial with a larger sample size is required.

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Section: Discussionsupporting

confidence: 70%

A preliminary investigation of schedule parameters on cocaine abstinence in contingency management

Regnier

Strickland²,

Stoops

2022

J Exper Analysis Behavior

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“…As the model could not be fit to data from zero-responders, in these cases Q 0 , O max , P max , BP, and EV (i.e., the lowest potential value) as have been done under similar circumstances in previous research (Heckman et al, 2019; Stein et al, 2017; Yoon et al, 2020; Yoon, Suchting, de Dios, et al, 2021).…”

Section: Methodsmentioning

confidence: 99%

“…Each demand index was fit as a function of LPP difference score. GLM was able to account for the nonnormal distribution of each demand characteristic through specification of link functions, an approach we have used in previous work (Yoon, Suchting, de Dios, et al, 2021). GLM fit each demand characteristic (distributed with a mass of zero values and a lognormal process for positive values) via a hurdle distribution (Neelon et al, 2010) that models the probability of a zero (vs. a positive) response as a binomial function, then the positive values as a lognormal function.…”

Section: Methodsmentioning

confidence: 99%

“…Drug demand is a behavioral economic measure quantifying motivational aspects of a drug (e.g., drug reward value, abuse liability), typically assessed using hypothetical drug purchasing tasks in which individuals are asked how much drug they would purchase and consume as a function of increasing price (Roma et al, 2017). Drug demand is associated with clinically relevant measures of drug use severity (Strickland et al, 2020; Zvorsky et al, 2019) across numerous drugs of abuse, including cocaine (Bruner & Johnson, 2014; Petry, 2000, 2001; Strickland, Lile, et al, 2016; Yoon, de Dios, Suchting, Vincent, et al, 2021; Yoon et al, 2020; Yoon, Suchting, de Dios, et al, 2021). Our group recently observed that baseline cocaine demand predicts treatment response for individuals receiving contingency management for CUD and, importantly, decreases over time as a function of continued abstinence (Yoon et al, 2020; Yoon, Suchting, de Dios, et al, 2021).…”

mentioning

confidence: 99%

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Assessing cocaine motivational value: Comparison of brain reactivity bias toward cocaine cues and cocaine demand.

Webber¹,

Yoon²,

Dios³

et al. 2023

Experimental and Clinical Psychopharmacology

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The behavioral economic measure drug demand and the neural measure late positive potential (LPP) are two measures of motivational value that have been associated with drug relapse risk and treatment outcomes. Despite having overlapping themes, no studies have directly compared drug demand and LPP. Participants (N = 59) included treatment-seeking individuals with cocaine use disorder that had completed both a baseline cocaine demand task and an electroencephalogram (EEG) picture-viewing task of drug-related and pleasant picture cues. Associations between the LPP difference score amplitude (drug − pleasant) and five demand indices (Q 0 , essential value [EV], O max , P max , and breakpoint [BP]) were evaluated via Bayesian generalized linear modeling. Positive associations (posterior probabilities ≥75%) were found between LPP amplitude and four demand indices (Q 0 , EV, O max , BP). These results suggest that individuals who attach greater relevance to cocaine cues also exhibit greater valuation of cocaine reward. Implications for incorporating methodology from behavioral science and brain imaging are discussed. Public Health SignificanceThis study found that higher brain reactivity toward cocaine cues compared to nondrug rewards was related to greater motivation to purchase and consume cocaine despite increasing cost of drug. These results highlight a potential avenue for future interventions to target the motivational value of drug reward, which could potentially lead to a decrease in cocaine demand.

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“…Since the value of α is impossible to estimate in zero responders, according to previous studies (Heckman et al, 2019 ; Stein et al, 2017 ; Yoon et al, 2021 ), the EV was defined as 0 (i.e., the lowest potential value).…”

Section: Methodsmentioning

confidence: 99%

Effects of episodic future thinking on reinforcement pathology during smoking cessation treatment among individuals with substance use disorders

et al. 2022

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Rationale Reinforcer pathology (RP) is a theoretical model based on two processes: delay discounting (DD) and drug demand. Given that RP has been shown to have a predictive value on smoking behaviors, several studies have explored which interventions can reduce RP. Consistent with the RP framework, episodic future thinking (EFT) has shown effects on treatment outcomes and RP processes. The vast majority of studies that assess the effects of EFT on RP consist of experimental studies, and no previous research has tested these effects in a clinical sample of smokers. Objectives The primary aim of this study was to assess the effects of EFT on RP throughout the course of a smoking cessation intervention in smokers with substance use disorders (SUDs). Methods Participants were randomized to cognitive behavior therapy (CBT) + EFT (n = 39) or CBT + EFT + contingency management (n = 33). Cotinine, frequency of EFT practices, cigarette purchase task (CPT), and DD were evaluated in treatment sessions. Mixed-effects model repeated measures analysis was used to explore DD and CPT in-treatment changes as a function of EFT practices and cotinine levels. Results Greater practice of the EFT component significantly reduced cigarette demand (p < .020) as well as DD (p = .003). Additionally, a greater reduction in cotinine levels coupled with greater EFT practice led to a greater decrease in cigarette demand (p < .014). Conclusions EFT reduced the two facets of RP in treatment-seeking smokers with SUDs.

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Decreased cocaine demand following contingency management treatment

Cited by 12 publications

References 74 publications

A preliminary investigation of schedule parameters on cocaine abstinence in contingency management

A preliminary investigation of schedule parameters on cocaine abstinence in contingency management

Assessing cocaine motivational value: Comparison of brain reactivity bias toward cocaine cues and cocaine demand.

Effects of episodic future thinking on reinforcement pathology during smoking cessation treatment among individuals with substance use disorders

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