Decreased Circulating Level in Parallel With Lack of Associated Genetic Variation in CXCL10 (IP-10) in Southeastern Post-Transfusion Occult HBV-Infected Patients

Karimabad, Mojgan Noroozi; Hassanshahi, Gholamhossein; Arababadi, Mohammad Kazemi; Shabani, Ziba; Shamsizadeh, Ali; Rafatpanah, Houshang; Yaghini, Narges; Shirdel, Abbas

doi:10.1309/lm1i1ll2guxfqhol

Cited by 5 publications

(3 citation statements)

References 9 publications

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“…Chemokinesas a subgroup of leukocyte recruiter cytokines exhibit several biological functions that vary from recruitment of leukocytes to the sites of injury, infection, and inflammation to balancing between angiogenesis and angiostasis [13]. This family of chemotactic mediators is according to the position of cysteine motifs in their structure classified into CC, CX3C, C, and CXC subfamilies [14][15][16][17]. Stromal cell-derived factor-1 alpha (SDF-1α) which is known as C-X-C motif ligand 12 (CXCL12) in the most recent chemokine nomenclature fits into the CXC subgroup [18][19][20][21].…”

Section: Introductionmentioning

confidence: 99%

Significance of CXCL12 in Type 2 Diabetes Mellitus and Its Associated Complications

Karimabad

Hassanshahi

2014

Inflammation

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Immune responses are extensively accepted as primitive etiological leading causes involved in immune system diseases. It is now well established that chemokines as the main arms of the immune system play critical roles in the regulation of immune responses in the pathogenesis of different diseases. Several environmental and genetic elements of the immune system are also believed to potentially affect both the onsets of immunological diseases. The stromal cell-derived factor-1 alpha (SDF-1α) which in new nomenclature is nominated as C-X-C motif ligand 12 (CXCL12) is involved in the development and progression of immune responses. The CXCL12 is an extensively active chemokine that serves as a recruiter for migration and trafficking of leukocytes and hematopoietic progenitor cells. Patients suffering type 2 diabetes (T2D) that ascribe heterozygous SDF-1 3'A genotype (801G/A in the 3' untranslated region) have increased insulin-dependent mobilization of adult progenitor cells, which are known to participate in angiogenesis and vascular repair. Conversely, homing of progenitor cells contributes to the diabetes vascular complications. Because carriers of the SDF-1 3'A genotype show increased levels of the CXCL12 messenger RNA (mRNA) in their peripheral blood mononuclear cells. Genetic variations of CXCL12 gene might affect trafficking of inflammatory cells or defected precursors and hence induced tendency to diabetic complications. The SDF-1 3'A genetic variation of CXCL12 influences the development of late vascular diabetic complications, and previous studies reported that this genetic variation regulates the expression of CXCL12. Therefore, the main goal of the present study was to collect the most recent reports regarding the relation between serum concentrations and SDF-1 3'A genetic variation of CXCL12 in T2D.

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Section: Introductionmentioning

confidence: 99%

Significance of CXCL12 in Type 2 Diabetes Mellitus and Its Associated Complications

Karimabad

Hassanshahi

2014

Inflammation

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“…It seems that expression of IL-25 is disrupted in MS patients. It has been proposed that polymorphisms within cytokine genes are associated with their expression (18, 19). The authors of this study hypothesized that the polymorphisms within the IL-25 gene may be associated with MS disease; hence, the c424C/A polymorphism within the IL-25 gene was evaluated in this study.…”

Section: Discussionmentioning

confidence: 99%

The Association Between C424c/A Polymorphism Within the IL-25 Gene and Multiple Sclerosis

Zare¹,

Fathollahi²,

Arababadi³

et al. 2016

Iran Red Crescent Med J

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BackgroundMultiple Sclerosis (MS) is a common autoimmune system disease which affects the central nervous system. It has been documented that interleukin-25 (IL-25) plays key roles in suppressing Th1 responses, which is increased during MS.ObjectivesThe aim of this study was to investigate the c424C/A polymorphism within the IL-25 gene in MS patients in comparison to healthy controls.Patients and MethodsIn this case-control study, 74 patients with MS and 75 healthy controls were selected. Polymerase Chain Reaction-Restriction Fragment Length Polymorphism (PCR-RFLP) was used in order to determine c424C/A polymorphism within the IL-25 gene.ResultsThe results showed that there was no statistical significant difference in distribution of genotype (AA, AC and CC) and allele (A and C) frequencies between MS patients and healthy controls (P = 0.901 and P = 0.728, respectively).ConclusionsIn conclusion, it appears that the c424C/A polymorphism within the IL-25 gene has no significant relationship with MS, and this polymorphism is probably not associated with MS complications, its onset and gender distribution.

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“…Chemokines are a subgroup of chemotactive cytokines with a broad range of biological functions that vary from recruitment of leukocytes to the sites of injury, infection, and inflammation to angiogenesis and angiostasis [10] . These groups of chemotactive factors are structurally subdivided into 4 categories, i.e., CC, CX3C, C, and CXC, according to the position of cysteine motifs in their biostructure [10][11][12][13][14][15] . Stromal cell-derived factor-1 (SDF-1; known as CXCL12 in the recent chemokine nomenclature) is described as a CXC chemokine [unpubl.…”

Section: Introductionmentioning

confidence: 99%

Significant Role(s) of CXCL12 and the SDF-1 3′A Genetic Variant in the Pathogenesis of Multiple Sclerosis

Karimabad

Falahati-Pour

Hassanshahi³

2016

Neuroimmunomodulation

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Both cellular and molecular components of the immune system are among the substantial factors involved in the pathogenesis of multiple sclerosis (MS). Accumulating evidence confirms that chemokines, as the main members of the immune system, play key roles in the regulation of immune responses. Immune system genetic parameters are believed to influence the onset of immune system-related diseases. Regarding the significant role of the CXCR4/CXCL12 axis in cell differentiation and survival and homing of hematopoietic progenitors to the bone marrow and regulation of neuronal progenitor cell migration in the central nervous system (CNS), genetic factors can cause an increased expression of CXCL12 and induce a vigorous immune response against CNS antigens in MS patients. Previous studies have indicated that the expression of CXCL12 could be affected by its polymorphisms at position +801 at the region of the CXCL12 3′A genetic variation. Finally, CXCL12 seems to be involved in the cellular part of the events that take place in the CNS, and therefore it could be considered as a target in MS therapies. Thus, this review was aimed to describe the recent progress in understanding the role of CXCL12 in MS, with an emphasis on CXCL12 serum concentrations and its gene polymorphism at position +801.

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Decreased Circulating Level in Parallel With Lack of Associated Genetic Variation in CXCL10 (IP-10) in Southeastern Post-Transfusion Occult HBV-Infected Patients

Cited by 5 publications

References 9 publications

Significance of CXCL12 in Type 2 Diabetes Mellitus and Its Associated Complications

Significance of CXCL12 in Type 2 Diabetes Mellitus and Its Associated Complications

The Association Between C424c/A Polymorphism Within the IL-25 Gene and Multiple Sclerosis

Significant Role(s) of CXCL12 and the SDF-1 3′A Genetic Variant in the Pathogenesis of Multiple Sclerosis

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