Decreased choroidal thickness in vitiligo patients

Demirkan, Serkan; Onaran, Zafer; Samav, Güzin; Özkal, Fatma; Yumuşak, Erhan; Gündüz, Özgür; Karabulut, Ayşe Anıl

doi:10.1186/s12886-018-0796-0

Cited by 16 publications

(35 citation statements)

References 22 publications

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“…The lower SFCT in the cases is in line with the recent work by Demirkan et al, 17 although the mean SFCT in their cases was lower than the mean SFCT in our studied cases (221 μm and 252 μm, respectively); the same difference was found in our control groups. The different ethnicities of the study subjects in the two studies (Turkish population vs Egyptian population) may explain the difference in mean choroidal thickness measurements as ethnicity is reported to affect choroidal thickness.…”

Section: Discussionsupporting

confidence: 93%

“…We could find two studies with ophthalmic assessment of vitiligo patients that included visual acuity comparisons with controls, and in both studies, the results showed that the difference was not statistically significant. 17,22 Furthermore, we correlated CDVA values with SFCT measurements and found a weak, albeit borderline statistically significant, correlation which could provide a possible explanation. Although this is a novel finding, the small sample size and the possibility of confounders dictate further assessments before arriving at any conclusions.…”

Section: Discussionmentioning

confidence: 79%

“…Patients presenting to the vitiligo clinic were asked for full history of their disease and the Vitiligo Area Scoring Index (VASI) was calculated as described in the literature (Σ all body sites (hand units) x depigmentation). 17 All study subjects underwent a full ophthalmological examination including corrected distance visual acuity (CDVA) measurement using a Snellen chart, slit-lamp biomicroscopy, intraocular pressure (IOP) measurement using Goldmann Applanation Tonometry, cycloplegic refraction, and fundus examination.…”

Section: Study Proceduresmentioning

confidence: 99%

“…A single recent report has examined choroidal thickness in vitiligo patients and the results demonstrated a significant reduction in thickness in such patients with no relation to disease duration and with some correlation to disease severity. 17 We set out to investigate SFCT in vitiligo patients in comparison to a control group, and any correlation it may have to disease severity and duration.…”

Section: Introductionmentioning

confidence: 99%

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<p>Assessment of the Effect of Vitiligo on Subfoveal Choroidal Thickness Using Spectral-Domain Optical Coherence Tomography</p>

Fouad

Salman

Mohamed

et al. 2020

OPTH

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Background: Vitiligo is a common skin condition affecting 0.5-2% of the population. The exact etiology of the condition is unknown, but the result is autoimmune destruction of melanocytes. The eye is rich in melanocytes, especially in the retinal pigment epithelium and choroid. Little is known about the effect of vitiligo on the choroid of the eye. Methods: We cross-sectionally examined 31 right eyes of 31 vitiligo patients and 32 right eyes of 32 age-and sex-matched controls for signs of vitiligo affection and then measured the subfoveal choroidal thickness (SFCT) using spectral-domain optical coherence tomography. Results: There was a statistically significant difference between SFCT in the cases group and the control group (Mean ± SD: 251.9 ± 42.0 μm and 296.8 ± 46.4 μm, respectively, p = 0.0002). The thickness correlated negatively with age (r = −0.5) but did not correlate significantly with disease severity or duration (r = −0.201, −0.1781, p = 0.2783, 0.3381, respectively). Additional examination findings included iris and fundus hypopigmented spots, and peripapillary atrophy. Conclusion: SFCT is reduced among patients with vitiligo. The clinical implications of such a finding should be studied further, and eye screening programs should be considered.

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Section: Discussionsupporting

confidence: 93%

Section: Discussionmentioning

confidence: 79%

Section: Study Proceduresmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

<p>Assessment of the Effect of Vitiligo on Subfoveal Choroidal Thickness Using Spectral-Domain Optical Coherence Tomography</p>

Fouad

Salman

Mohamed

et al. 2020

OPTH

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“…Demirkan et al found thinning in all choroidal layers in patients with vitiligo but stated that periorbital involvement had no effect on choroidal thickness 9 . Karabaş et al found that choroidal thickness in the subfoveal area was quite low in patients with oculocutaneous albinism 15 .…”

Section: Discussionmentioning

confidence: 99%

Retinal nerve fiber layer, retinal pigment epithelium, and choroidal thickness in vitiligo patients

Öncül

Ayhan

2020

J of Cosmetic Dermatology

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Background Vitiligo is one of the common pigmentary disorders affecting the ocular structures. Aim To determine the retinal nerve fiber layer (RNFL), retinal pigment epithelium (RPE), and choroidal thickness (CT) in vitiligo patients and to evaluate the relationship between choroidal thickness and vitiligo subtypes. Methods The right eyes of 106 participants (51 vitiligo, 55 nonvitiligo) were included in the study. All of the participants underwent detailed eye examinations and spectral‐domain optical coherence tomography (SD‐OCT) examinations. CT was measured manually with enhanced depth imaging optical coherence tomography (Edi‐OCT) (subfoveal [SubF], nasal n500 µm [N1], n1500 µm [N2]), and temporal (t500 µm [T1], t1500 µm [T2]). Results In vitiligo patients, CT values were significantly lower in the SubF, N1, N2, T1, and T2 areas compared to the control group (P = .001, P = .011, P = .002, P = .005, P ˂ .001, respectively). Periorbital involvement did not affect CT (P = .355, P = .746, P = .443, P = .633, P = .558, respectively). However, in patients with periorbital region involvement, the CT was significantly reduced if the lesion had a universal character (P ˂ .001, P = .001, P = .011, P ˂ .001, P = .002, respectively). It was observed that RPE thickness decreased in vitiligo, but this difference was not statistically significant (P = .140). RNFL thickness was unaffected in all quadrants. A positive correlation (r = .286, r = .280, respectively) was observed between the Vitiligo Area Severity Index (VASI) and age and disease duration. A negative correlation (r = −.360, r = −.316, r = −.315, r = −.313, respectively) was found in the CT of the SubF, N1, N2, T1, and T2 areas. Conclusion Vitiligo patients should be closely monitored for possible posterior ocular segment disorders.

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Isolated choroidal melanocytosis: clinical update on 37 cases

Augsburger

Brooks

Corrêa

2020

Graefes Arch Clin Exp Ophthalmol

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Purpose Isolated choroidal melanocytosis is a congenital melanocytic hyperpigmentation involving the choroid that is not associated with iridic or scleral features of ocular melanocytosis. The purpose of this work was to describe the clinical features and course of a relatively large series of patients with this disorder. Methods A retrospective clinical study of 37 patients with isolated choroidal melanocytosis encountered in a single practice 1986–2018 was done. All lesions were 5 mm or larger in the largest basal diameter, homogeneously melanotic, and completely flat by conventional ocular ultrasonography. Results The 37 patients ranged in age from 2 weeks to 87 years (mean 31.5 years, median 18 years) at initial diagnosis of the melanotic choroidal lesion. Arc length largest basal diameter of the melanotic choroidal lesion ranged from 5.5 to 37 mm (mean 14.6 mm, median 13 mm). The lesion extended beneath the fovea in 18 eyes and to the optic disc margin in 6 eyes. Ten of the lesions straddled the ocular equator, but the center point of all of the lesions was posterior to the equator. The retina was fully attached and appeared normal over the melanotic choroidal lesion in each of these eyes. None of the melanotic choroidal lesions exhibited clumps of orange pigment or drusen on its surface. The lesion was unilateral and unifocal in 36 of the 37 patients. One patient had bilateral choroidal melanocytosis that was isolated in one eye but associated with partial iris melanocytosis in the fellow eye. Three adult patients had a choroidal melanoma localized to the patch of choroidal melanocytosis at baseline. One other adult patient had a choroidal melanoma in the fellow eye at baseline. One pediatric patient had viable unilateral non-familial retinoblastoma in the fellow eye and two adult patients had a classic choroidal nevus in the fellow eye. None of the flat patches of choroidal melanocytosis that were monitored periodically after initial diagnosis expanded appreciably during follow-up ranging from 4.9 months to 15.2 years (mean 5.0 years, median 2.3 years). Conclusions Isolated choroidal melanocytosis is a distinct clinical entity that must be distinguished from broad-based choroidal nevus, choroidal melanocytoma, small choroidal malignant melanoma, acquired bilateral patchy-streaky choroidal melanocytic fundopathy associated with disorders such as cutaneous vitiligo and Waardenburg syndrome, acquired bilateral zonal choroidal melanocytic fundopathy, and diffuse uveal melanocytic proliferation associated with systemic cancer. This disorder appears to predispose affected eyes to development of choroidal melanoma arising from the hypermelanotic patch.

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Decreased choroidal thickness in vitiligo patients

Cited by 16 publications

References 22 publications

<p>Assessment of the Effect of Vitiligo on Subfoveal Choroidal Thickness Using Spectral-Domain Optical Coherence Tomography</p>

<p>Assessment of the Effect of Vitiligo on Subfoveal Choroidal Thickness Using Spectral-Domain Optical Coherence Tomography</p>

Retinal nerve fiber layer, retinal pigment epithelium, and choroidal thickness in vitiligo patients

Isolated choroidal melanocytosis: clinical update on 37 cases

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