Decreased choroidal blood flow associated with retinitis pigmentosa

Langham, Maurice E.; Kramer, Theresa R.

doi:10.1038/eye.1990.50

Cited by 96 publications

(82 citation statements)

References 19 publications

(1 reference statement)

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“…Impaired oxygenation and a reduced nutrient supply may thus contribute to the reduction in retinal and choroidal blood flow. Reductions in retinal and choroidal circulation and volume have previously been shown to occur in hereditary retinal disorders and in animal models of disease (4,14,15) . Consequently, the choroidal thinning observed in our patients may be a manifestation of decreased choroidal blood flow and may indicate reduced oxygen dependence in the retina.…”

Section: Discussionmentioning

confidence: 99%

Is there a relationship between outer retinal destruction and choroidal changes in cone dystrophy?

Ayyıldız¹,

Özge²,

Küçükevcilioğlu³

et al. 2016

Arquivos Brasileiros De Oftalmologia

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Approved by the following research ethics committee: GATA Medical School (# 2015-KAEK-45). ABSTRACT Purpose:The aim of the present study was to use enhanced depth imaging optical coherence tomography (EDI-OCT) to investigate choroidal changes in patients with cone dystrophy (CD) and to correlate these findings with clinical and electroretinography (ERG) findings. Methods: This case-control study included 40 eyes of 20 patients with CD and 40 eyes of 40 age-and refraction-matched healthy individuals. Choroidal thickness (CT) measurements were obtained under the foveal center and at 500 and 1,500 µm from the nasal and temporal regions to the center of the fovea, respectively. EDI-OCT and ERG data were analyzed, and the correlations of CT with the best-corrected visual acuity (BCVA) and the central foveal thickness (CFT ) were evaluated. Results: The mean subfoveal CTs in the CD and control groups were 240.70 ± 70.78 and 356.18 ± 48.55 µm, respectively. The subfoveal CT was significantly thinner in patients with CD than in the controls (p<0.001). The patients with CD also had significantly thinner choroids than the controls at each measurement location relative to the fovea (p<0.001). The subfoveal CT in the CD group correlated with CFT (p=0.012), but no significant correlation was found between the subfoveal CT and BCVA or photopic ERG responses. Conclusions:The present study demonstrated a significant thinning of the choroid in patients with CD. EDI-OCT is a useful technique for describing the choroidal changes occurring in CD. Future studies investigating the association between choroidal changes and outer retinal destruction or the disease stage may provide a better understanding of the pathophysiology of CD.

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Section: Discussionmentioning

confidence: 99%

Is there a relationship between outer retinal destruction and choroidal changes in cone dystrophy?

Ayyıldız¹,

Özge²,

Küçükevcilioğlu³

et al. 2016

Arquivos Brasileiros De Oftalmologia

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“…The choroidal vessels reveal a marked periadventitious fibrosis [22]with choriocapillaris hyalinosis [23, 24]. Many hemodynamic studies carried out in RP have demonstrated a reduction in blood flow at a choroidal [15, 16]and retinal level [14]. …”

Section: Discussionmentioning

confidence: 99%

“…Hemodynamic studies have demonstrated that RP is associated with a reduction in retinal and choroidal blood flow [14, 15, 16]. Retinal hemodynamic impairment is also present in early stages of RP and various hypotheses have been advanced as to its cause [17, 18].…”

Section: Introductionmentioning

confidence: 99%

Plasma Levels of Endothelin-1 in Retinitis Pigmentosa

Cellini¹,

Santiago²,

Versura³

et al. 2002

Ophthalmologica

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Retinitis pigmentosa (RP) is an inherited retinal disorder clinically characterized by a pale, waxy optic nerve head, attenuated retinal blood vessels and bone spicule pigment in the retina. Hemodynamic studies have demonstrated that RP is associated with a reduction in the retinal and choroidal blood flow. Retinal hemodynamic impairment is also present in the early stages of RP and various hypotheses have been advanced as to its cause. The authors studied 20 patients, 12 males and 8 females, aged between 26 and 42 years (mean 34.6 years) affected by simplex RP. The twenty patients were divided in two groups according to the degree of sight impairment: group A consisted of 10 patients with a visual acuity of 0.3 ± 0.1, visual field mean defect 18.988 ± 3.419 dB and b-wave electroretinogram amplitude of 13.14 ± 0.308 µV. Group B consisted of 10 patients with a visual acuity of 0.8 ± 0.2, visual field MD 10.523 ± 3.582 dB and b-wave electroretinogram amplitude of 26.000 ± 0.757 µV. An increase in plasma levels of endothelin-1 (ET-1) was found as compared with healthy controls: 1.910 ± 0.617 pg/ml vs. 1.180 ± 0.210 pg/ml (p < 0.021), but there was no statistical difference between group A and B (p < 0.163). It is thought that an increase in ET-1 and retinal oxygen levels in RP could lead to vasoconstriction and a decrease in the retinal blood flow worsening the abiotrophic process.

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“…5 It has been clinically applied to investigate in various ocular diseases including glaucoma, 6,7 age-related macular degeneration, 8,9 diabetic retinopathy, 10,11 choroidal melanoma, 12 and retinal pigmentosa. 13 Graves' disease (GD) is an autoimmune disorder characterized by hyperthyroidism, diffuse goitre, ophthalmopathy, and rarely, dermopathy. One hypothesis for the pathogenesis of Graves' ophthalmopathy (GO) is that the immune response to thyroidstimulating hormone (TSH) receptor-like protein in orbital connect tissue initiates cytokine formation, promoting production by orbital fibroblasts of hydrophilic glycosaminoglycans, resulting in increased osmotic pressure, extraocular muscle volume, fluid accumulation, and clinical ophthalmopathy.…”

Section: Introductionmentioning

confidence: 99%

Pulsatile ocular blood flow in patients with Graves' ophthalmopathy

Tsai

Kau

Kao

et al. 2004

Eye

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Purpose Graves' ophthalmopathy (GO) is a cosmetically disfiguring and visionthreatening complication of Graves' disease (GD). We investigated the clinical application of pulsatile ocular blood flow (POBF) measurement for detection of clinically active GO. Methods In this prospective study, the OBF tonometer (OBF Labs, Wiltshire, UK) was used to measure POBF in 83 eyes of 83 patients with GD in two groups and 42 normal control subjects. Group A comprised 35 GD patients without ophthalmopathy, and group B composed 48 GD patients with ophthalmopathy. Results were compared with controls. Results Pulse amplitude, pulse volume, and POBF were significantly lower in group B than that in group A and controls (Po0.001). After adjusting for age, sex, systolic blood pressure, diastolic blood pressure, heart rate, intraocular pressure, and axial length, multivariate linear regression analysis showed that POBF was still significantly lower in eyes with GO (772.4 (SD 279.3) ll/min) than group A (1177.3 (SD 326.3) ll/min) and controls (1255.4 (SD 295.1) ll/min) (Po0.001). Conclusions These data show that the pulsatile ocular blood flow differences between the groups are relevant to the presence of GO. POBF measurement is a clinically useful adjunct for assessing the haemodynamic change in GO patients.

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Decreased choroidal blood flow associated with retinitis pigmentosa

Cited by 96 publications

References 19 publications

Is there a relationship between outer retinal destruction and choroidal changes in cone dystrophy?

Is there a relationship between outer retinal destruction and choroidal changes in cone dystrophy?

Plasma Levels of Endothelin-1 in Retinitis Pigmentosa

Pulsatile ocular blood flow in patients with Graves' ophthalmopathy

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