Decreased cerebral vasomotor reactivity in patients with obstructive sleep apnea syndrome

Öz, Oğuzhan; Taşdemir, S.; Akgün, Hakan; Erdem, Murat; Balıkçı, Adem; Cetiz, A.; Yücel, Mehmet; Ulaş, Ümit Hıdır; Demirkaya, Şeref; Kutukcu, Yasar; Özgen, Fuat

doi:10.1016/j.sleep.2016.09.020

Cited by 11 publications

(4 citation statements)

References 37 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…In several scientific works, it has been shown that, in patients with OSAS, there is a reduction of the cerebral vasodilator reserve, and that this is one of the main factors of increased susceptibility to cerebral ischemia in this population . In our study, the mean BHI value is comparable to those found in a recent work by Oz et al which demonstrated that cerebral vascular regulation was impaired . Our data show that CBF and vasoreactivity improve after CPAP treatment, reducing in part the risk of ischemic stroke.…”

Section: Discussionsupporting

confidence: 85%

“…24 In our study, the mean BHI value is comparable to those found in a recent work by Oz et al which demonstrated that cerebral vascular regulation was impaired. 25 Our data show that CBF and vasoreactivity improve after CPAP treatment, reducing in part the risk of ischemic stroke. No reported study has addressed the effect of CPAP on CBF in patient OSAS, using TCD.…”

Section: Discussionmentioning

confidence: 53%

See 1 more Smart Citation

Effect of OSAS on cerebral vasoreactivity and cIMT before and after CPAP treatment

Piraino

Sette

D’Ascanio

et al. 2019

Clinical Respiratory J

View full text Add to dashboard Cite

Introduction Obstructive sleep apnea syndrome (OSAS) has been shown to be an important risk factor for ischaemic cerebral disease. Specific Doppler parameters may be used to measure cerebral vascular dynamics opening the door to new markers/predictors of risk. The objective of our study was to shed light on how the treatment of OSA with continuous positive airway pressure (CPAP) may have an impact on these parameters and, consequently, lower the risk of cerebral ischemic events in these patients. Methods A total of 40 untreated patients diagnosed with moderate to severe obstructive sleep apnoea were submitted to a comprehensive ultrasonographic transcranial Doppler evaluation. The parameters measured were: Breath holding index (BHI), mean blood flow velocity (MBFV) and pulsatility index in middle cerebral artery. Colour Doppler ultrasound was also used to measure carotid intima‐media thickness (cIMT). These parameters were compared before and after CPAP treatment. Results After CPAP treatment, MBFV and BHI were shown to be increased (without statistical significance), while cIMT and polysomnographic parameters were significantly decreased. Conclusion The improvement of cerebral vasoreactivity parameters and cIMT after long‐term CPAP treatment suggest that treatment of OSA may influence the cerebral vascular regulation and consequently reduce the risk of stroke.

show abstract

Section: Discussionsupporting

confidence: 85%

Section: Discussionmentioning

confidence: 53%

Effect of OSAS on cerebral vasoreactivity and cIMT before and after CPAP treatment

Piraino

Sette

D’Ascanio

et al. 2019

Clinical Respiratory J

View full text Add to dashboard Cite

show abstract

“…Bek et al (2010) showed that in epilepsy patients, cerebral blood flow increases, which is indicative of the vasodilation capacity of arterioles by BHM using Doppler ultrasound, which is more pronounced than in healthy volunteers. In addition, Oz et al (2017) demonstrated decreased cerebral vasomotor reactivity in patients with obstructive sleep apnoea using the BHI. These studies inspired us to establish and use BHI in the evaluation of retinal vasoreactivity.…”

Section: Discussionmentioning

confidence: 92%

Optical coherence tomography angiography of central serous chorioretinopathy patients’ response to breath‐holding manoeuvre

Karapapak

Güven

Demir

et al. 2020

Acta Ophthalmologica

View full text Add to dashboard Cite

Purpose To demonstrate through the use of optical coherence tomography angiography (OCTA) that normal vasoreactivity cannot be monitored in central serous chorioretinopathy (CSR) patients in the presence of vasoactive stimuli owing to hypoxia caused by the breath‐holding manoeuvre (BHM). Methods This cross‐sectional study included a total of 210 eyes, including 70 CSR patients (70 symptomatic eyes, 70 asymptomatic eyes) and 70 control group. Images of the macula (3 × 3 mm) and the optic disc (4.5 × 4.5 mm) were obtained at the baseline and after BHM using OCTA. The change in vascular parameters in the OCTA after BHM was evaluated in CSR patients and the control group. Results In the symptomatic eyes of CSR patients, the mean whole image vessel density (VD) in the superficial capillary plexus decreased from 48.0 ± 3.5% under baseline conditions to 46.0 ± 4.5% after BHM (p < 0.01), and the mean whole VD in the deep capillary plexus decreased from 47.9 ± 8.0% under baseline conditions to 46.9 ± 6.7% after BHM (p < 0.01). The OCTA after BHM revealed a decrease in the mean whole image VD of the optic disc in both symptomatic (50.4 ± 2.1% to 49.6 ± 2.0%, p < 0.05) and asymptomatic (50.9 ± 1.8% to 50.4 ± 1.9%, p < 0.05) eyes of CSR patients. No difference for any mean VD of the control group was seen between the baseline and after BHM. Outer retinal flow areas increased significantly after BHM compared with the baseline in both eyes of CSR patients. Conclusion These results suggest that CSR pathogenesis is related to an imbalance in local vascular regulation and the sympathetic activity of the autonomic nervous system. This technique constitutes a new way of studying retinal vascular changes and may be applied to CSR patients.

show abstract

“…Полученные результаты позволили авторам предположить, что лечение ОАС может положительно влиять на регуляцию церебральных сосудов и, следовательно, снижать риск сосудистых осложнений. Oz O, et al (2017) [46] при анализе цереброваскулярной реактивности у 30 нелеченых пациентов с ОАС тяжелой степени и 26 пациентов контрольной группы установили, что средняя скорость кровотока и показатели пробы с задержкой дыхания были значительно снижены в группе больных по сравнению со здоровыми лицами. Полученные данные свидетельствуют о том, что у пациентов с ОАС наблюдался ухудшенный вазодилататорный ответ на гиперкапнию, вероятно, по причине эндотелиальных повреждений.…”

unclassified

Ultrasound techniques in the diagnosis of vascular structural changes and blood flow velocity in patients with obstructive sleep apnea

Bolshakova

Мадаева

Бугун

et al. 2021

Cardiovasc Ther Prev

View full text Add to dashboard Cite

ФГБНУ "Научный центр проблем здоровья семьи и репродукции человека". Иркутск, Россия Обструктивное апноэ сна (ОАС) представляет собой распространенное расстройство дыхания, связанное со сном, и повышает риск развития кардиоваскулярной патологии. В настоящее время накоплено достаточное количество доказательств того, что ОАС увеличивает риск развития сердечно-сосудистых заболеваний, однако механизмы, лежащие в основе формирования этих изменений, остаются не до конца ясными. Использование ультразвукового метода с допплерографией и функциональных нагрузочных проб у пациентов с ОАС позволит уточнить состояние сосудистой стенки и отследить динамку ее изменений на фоне проводимого лечения. Данный метод может быть включен в программу обследования пациентов с нарушением дыхания во сне. Ключевые слова: обструктивное апноэ сна, транскраниальное дуплексное сканирование, проба с реактивной гиперемией, дисфункция эндотелия.Отношения и деятельность: нет.

show abstract

Decreased cerebral vasomotor reactivity in patients with obstructive sleep apnea syndrome

Cited by 11 publications

References 37 publications

Effect of OSAS on cerebral vasoreactivity and cIMT before and after CPAP treatment

Effect of OSAS on cerebral vasoreactivity and cIMT before and after CPAP treatment

Optical coherence tomography angiography of central serous chorioretinopathy patients’ response to breath‐holding manoeuvre

Ultrasound techniques in the diagnosis of vascular structural changes and blood flow velocity in patients with obstructive sleep apnea

Contact Info

Product

Resources

About