Decreased caudal anterior cingulate gyrus volume and positive symptoms in schizophrenia

Choi, Jung Seok; Kang, Do Hyung; Kim, Jae Jin; Ha, Tae Hyon; Roh, Kwang Soo; Youn, Tae Jin; Kwon, Jun Soo

doi:10.1016/j.pscychresns.2004.05.008

Cited by 55 publications

(21 citation statements)

References 43 publications

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“…The existing literature on high-risk and schizophrenic samples implicates the CG in the pathology of psychosis (Borgwardt et al, 2007;Pantelis et al, 2003;Yamasue et al, 2004). Suzuki and colleagues (2005) suggest that loss of inhibitory control, typically regulated in networks involving the prefrontal cortex and the anterior CG (Kerns et al, 2004), may be significant to the development of such symptoms, related to an anterior CG grey matter volume reduction in schizophrenia (Choi et al, 2005;Wang et al, 2007). Concordantly, Allen et al (2008) review several reports illustrating anterior CG activity deficits during hallucinatory experiences.…”

Section: Discussionmentioning

confidence: 99%

“…These self-monitoring deficits, shown to involve the anterior CG , can promote the expression of hallucinations . Accordingly, both structural and functional alterations in the anterior CG are present among psychotic patients with positive symptoms (Choi et al, 2005;Shergill, Brammer, Williams, Murray, & McGuire, 2000;Wang et al, 2007). Therefore, given that 22q11DS patients are particularly prone to experience positive symptoms like hallucinations from a young age (Baker & Skuse, 2005;, a careful analysis of CG structure and associated clinical symptoms seems worthwhile.…”

Section: Introductionmentioning

confidence: 99%

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Cingulate gyral reductions are related to low executive functioning and psychotic symptoms in 22q11.2 deletion syndrome

et al. 2008

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Cingulate gyral reductions are related to low executive functioning and psychotic symptoms in 22q11.2 deletion syndrome

et al. 2008

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“…The rostral emotion-oriented portion lies just anterior to the genu of the corpus callosum, while the caudal cognition-oriented area is found just superior to the body of the corpus callosum, as shown in Figure 1 ( 7 ). Volumetric studies have shown that both of these anatomic subregions are smaller in patients with schizophrenia than in control subjects ( 6,8 ), with the degree of volume loss correlated to the severity of negative symptoms in the rostral ACC ( 9 ) and to positive symptoms in the caudal ACC ( 10 ). Functional MR imaging, in which subjects engaged in emotional and cognitive tasks, revealed abnormal activity in both ACC segments in patients with schizophrenia (11)(12)(13).…”

Section: Human Subjectsmentioning

confidence: 96%

Multivoxel Proton MR Spectroscopy Used to Distinguish Anterior Cingulate Metabolic Abnormalities in Patients with Schizophrenia

Hardy¹,

Tal²,

Babb³

et al. 2011

Radiology

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Purpose:To test the hypothesis that anterior cingulate cortex (ACC) subregions in patients with schizophrenia are metabolically different from those in healthy control subjects. Materials and Methods:This institutional review board-approved study was HIPAA compliant, and all participants provided written informed consent. Twenty-two patients with schizophrenia (13 male, nine female; 39.4 years 6 10.6 [standard deviation]) and 11 age-and sex-matched control subjects (seven male, four female; 35.5 years 6 10.7) underwent magnetic resonance (MR) imaging and three-dimensional 3-T voxel proton MR spectroscopy to measure absolute rostral and caudal ACC N -acetylaspartate (NAA), creatine (Cr), and choline (Cho) concentrations. Exact Mann-Whitney test was used to compare patient data with control data, paired-sample Wilcoxon signed rank test was used to compare subregions within groups, and receiver operating characteristic curve analysis was used to assess sensitivity and specifi city in diagnosis of schizophrenia. Results:There were no signifi cant metabolic differences between patients and control subjects or between ACC subregions in control subjects. In patients, rostral ACC NAA and Cr concentrations were signifi cantly lower than those in caudal ACC (6.2 mM 6 1.3 vs 7.1 mM 6 1.3, P , .01; 5.7 mmol/L 6 1.4 vs 6.3 mmol/L 6 1.6, P , .01; respectively); however, this did not hold true for Cho concentrations (1.7 mmol/L 6 0.5 vs 1.8 mmol/L 6 0.5). For individual differences between caudal and rostral measurements, only NAA in patients was different from that in control subjects (0.9 mmol/L 6 1.3 vs 2 0.1 mmol/L 6 0.5, P , .01), enabling prediction of schizophrenia with 68% sensitivity and 91% specifi city, for a difference of more than 0.4. Conclusion:Signifi cant differences between caudal and rostral NAA concentration are found in ACC of patients with schizophrenia but not in ACC of healthy control subjects, indicating that neuronal density or integrity differences between ACC subregions may be characteristic of the disease.q RSNA, 20111 From the Departments of Radiology (C

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“…Note how the ACC P is not visible from the pial surface in ''absent'' or ''continuous'' cases. either left-sided [Haznedar et al, 2004;Paillere-Martinot et al, 2001], right-sided [Choi et al, 2005;Zhou et al, 2005], or bilateral reductions [Goldstein et al, 1999;Mitelman et al, 2005;Suzuki et al, 2002;Takahashi et al, 2003;Yamasue et al, 2004], with others reporting no volumetric changes [Crespo-Facorro et al, 2000;Noga et al, 1995;Riffkin et al, 2005;Szeszko et al, 1999] or even grey matter increases [Kopelman et al, 2005;Marquardt et al, 2005].…”

Section: Figurementioning

confidence: 99%

Surface‐based morphometry of the anterior cingulate cortex in first episode schizophrenia

Fornito

Yücel

Wood

et al. 2007

Human Brain Mapping

112

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The anterior cingulate cortex (ACC) appears to be critically involved in the pathophysiology of schizophrenia, but past attempts at characterizing pathological changes in the region using magnetic resonance imaging have been restricted by a limited appreciation of its functional and anatomical diversity and a reliance on relatively coarse metrics (e.g., volume) to index anatomical change. In this study, we applied a novel, surface-based protocol to T1-weighted scans acquired from 40 first episode schizophrenia patients and 40 healthy controls individually matched for age, sex, and morphology of the paracingulate sulcus, a major anatomical variation that has been shown to affect morphometric estimates in the region. The surface-based approach enabled calculation of regional grey matter volume, surface area and curvature, cortical thickness, and depth of the cingulate sulcus, with sub-millimeter precision. Relative to controls, schizophrenia patients displayed a bilateral reduction in thickness of paralimbic regions of the ACC, along with a concomitant increase in surface area of both the limbic and paralimbic ACC. No differences were identified for regional grey matter volume, surface curvature, or CS depth. These findings illustrate the advantages of moving beyond traditional volume-based approaches when investigating cortical morphometry, and indicate that the early stages of schizophrenia are associated with a specific pattern of ACC abnormalities that cannot be attributed to variations in sulcal and gyral morphology.

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Decreased caudal anterior cingulate gyrus volume and positive symptoms in schizophrenia

Cited by 55 publications

References 43 publications

Cingulate gyral reductions are related to low executive functioning and psychotic symptoms in 22q11.2 deletion syndrome

Cingulate gyral reductions are related to low executive functioning and psychotic symptoms in 22q11.2 deletion syndrome

Multivoxel Proton MR Spectroscopy Used to Distinguish Anterior Cingulate Metabolic Abnormalities in Patients with Schizophrenia

Surface‐based morphometry of the anterior cingulate cortex in first episode schizophrenia

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