Decreased Brain-Derived Neurotrophic Factor (BDNF) in Older Adults with Bipolar Disorder: Meaning and Utility?

Diniz, Breno S.

doi:10.1016/j.jagp.2016.03.003

Cited by 2 publications

(2 citation statements)

References 8 publications

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“…However, these findings were not consistent across all the studies. For instance, a previous study reported that the levels of mature BDNF and the ratio BDNF/proBDNF were significantly higher in patients with BD[ 88 ]. It was shown that pediatric bipolar patients had significantly higher levels of BDNF mRNA after eight weeks of treatment[ 89 ].…”

Section: Bdnf/pro-bdnf As Mediators Of Neuroimmune Crosstalk In Mood ...mentioning

confidence: 99%

Neuroimmune crosstalk through brain-derived neurotrophic factor and its precursor pro-BDNF: New insights into mood disorders

Zhao¹,

Li²,

Dai³

2022

WJP

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Mood disorders are the most common mental disorders, affecting approximately 350 million people globally. Recent studies have shown that neuroimmune interaction regulates mood disorders. Brain-derived neurotrophic factor (BDNF) and its precursor pro-BDNF, are involved in the neuroimmune crosstalk during the development of mood disorders. BDNF is implicated in the pathophysiology of psychiatric and neurological disorders especially in antidepressant pharmacotherapy. In this review, we describe the functions of BDNF/pro-BDNF signaling in the central nervous system in the context of mood disorders. In addition, we summarize the developments for BDNF and pro-BDNF functions in mood disorders. This review aims to provide new insights into the impact of neuroimmune interaction on mood disorders and reveal a new basis for further development of diagnostic targets and mood disorders.

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Section: Bdnf/pro-bdnf As Mediators Of Neuroimmune Crosstalk In Mood ...mentioning

confidence: 99%

Neuroimmune crosstalk through brain-derived neurotrophic factor and its precursor pro-BDNF: New insights into mood disorders

Zhao¹,

Li²,

Dai³

2022

WJP

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“…In addition to the permanent changes, several studies found a correlation between manic or depressive mood states and the levels of oxidative damage biomarkers in bipolar individuals [26]. In addition, neurotrophic factors, mainly brain-derived neurotrophic factor (BDNF), are important for neuroplasticity, a process that is impaired in patients suffering from BD [27,28], and Wnt and GSK-3 signaling [29] participate in the etiology of the disease. Despite these findings, none of these directions have led to the development of established anti-depressive or anti-manic drugs and all the available drugs are compounds that modify the monoamine system in the brain [7,12].…”

Section: Depressive and Bipolar Disorder (Bd)mentioning

confidence: 99%

Na+, K+-ATPase Signaling and Bipolar Disorder

Lichtstein¹,

Ilani²,

Rosen³

et al. 2018

IJMS

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Bipolar disorder (BD) is a severe and common chronic mental illness characterized by recurrent mood swings between depression and mania. The biological basis of the disease is poorly understood and its treatment is unsatisfactory. Although in past decades the “monoamine hypothesis” has dominated our understanding of both the pathophysiology of depressive disorders and the action of pharmacological treatments, recent studies focus on the involvement of additional neurotransmitters/neuromodulators systems and cellular processes in BD. Here, evidence for the participation of Na+, K+-ATPase and its endogenous regulators, the endogenous cardiac steroids (ECS), in the etiology of BD is reviewed. Proof for the involvement of brain Na+, K+-ATPase and ECS in behavior is summarized and it is hypothesized that ECS-Na+, K+-ATPase-induced activation of intracellular signaling participates in the mechanisms underlying BD. We propose that the activation of ERK, AKT, and NFκB, resulting from ECS-Na+, K+-ATPase interaction, modifies neuronal activity and neurotransmission which, in turn, participate in the regulation of behavior and BD. These observations suggest Na+, K+-ATPase-mediated signaling is a potential target for drug development for the treatment of BD.

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Decreased Brain-Derived Neurotrophic Factor (BDNF) in Older Adults with Bipolar Disorder: Meaning and Utility?

Cited by 2 publications

References 8 publications

Neuroimmune crosstalk through brain-derived neurotrophic factor and its precursor pro-BDNF: New insights into mood disorders

Neuroimmune crosstalk through brain-derived neurotrophic factor and its precursor pro-BDNF: New insights into mood disorders

Na+, K+-ATPase Signaling and Bipolar Disorder

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