Decreased blood levels of glyoxalase I and diabetic complications

Hamoudane, Meriem; Amakran, Amina; Bakrim, Naı̈ma; Nhiri, Mohamed

doi:10.1007/s13410-014-0237-4

Int J Diabetes Dev Ctries

2015

DOI: 10.1007/s13410-014-0237-4

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Decreased blood levels of glyoxalase I and diabetic complications

Meriem Hamoudane

Amina Amakran

Naı̈ma Bakrim

et al.

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Cited by 3 publications

References 36 publications

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Chemical Composition, Antifungal, Antioxidant, and Hemolytic Activities of Moroccan Thymus capitatus Essential Oil

Amakran,

Hamoudane,

Pagniez

et al. 2024

Chemistry & Biodiversity

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This study aimed to define the chemical composition of Moroccan Thymus capitatus essential oil, and to investigate its in vitro antioxidant and antifungal activities against human pathogenic fungi. Chemical analysis using GC‐FID and GC‐MS system revealed 28 constituents, representing 99% of total compounds. Oxygenated monoterpenes represented the highest proportion (79.79%), among which carvacrol (75.73%) was the predominant compound, followed by linalol (2.26%). Monoterpene hydrocarbons represented the second major fraction (16.29%): within them, the predominant constituents were γ‐terpinene (5,55%), ρ‐cymene (5,50%), and β‐caryophyllene (2.73%). Antioxidant activity was performed by DPPH scavenging, β‐carotene bleaching inhibition, and ferric reducing power. T. capitatus revealed pronounced DPPH radical scavenging activity (IC50=110.53μg.mL‐1), strong ferric reducing ability (EC50=644.4µg.mL‐1), and a remarkable degree of protection against lipid peroxidation during β‐carotene bleaching inhibition (IC50=251.76µg.mL‐1). Antifungal activity was carried out against Candida, Aspergillus, and Rhizopus species by microdilution method. T. capitatus exhibited potent anticandidal activity (MIC=125‐500µg.mL‐1) and strong inhibition against filamentous fungi (MIC=250‐500µg.mL‐1). Its hemolytic activity against human erythrocytes had a low toxic effect at concentrations lower than 1250µg.mL‐1. The useful antioxidant properties and broad antifungal effect of T. capitatus EO confirm its considerable potential for the food industry and for phytopharmaceutical production.

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Chemical Composition, Antifungal, Antioxidant, and Hemolytic Activities of Moroccan Thymus capitatus Essential Oil

Amakran,

Hamoudane,

Pagniez

et al. 2024

Chemistry & Biodiversity

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The genetic polymorphisms and activity of glyoxalase 1 as a risk factor for acute coronary syndrome in South Indians with type 2 diabetes mellitus

Bora

Adole

Vinod

et al. 2023

Gene

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Genetic polymorphism of glyoxalase I gene (A419C and C-7 T) and nephropathy risk in patients with type 2 diabetes mellitus among north Indian population: A case-control study

Nachimuthu,

Kanwar,

Rathore

et al. 2024

Human Gene

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Decreased blood levels of glyoxalase I and diabetic complications

Cited by 3 publications

References 36 publications

Chemical Composition, Antifungal, Antioxidant, and Hemolytic Activities of Moroccan Thymus capitatus Essential Oil

Chemical Composition, Antifungal, Antioxidant, and Hemolytic Activities of Moroccan Thymus capitatus Essential Oil

The genetic polymorphisms and activity of glyoxalase 1 as a risk factor for acute coronary syndrome in South Indians with type 2 diabetes mellitus

Genetic polymorphism of glyoxalase I gene (A419C and C-7 T) and nephropathy risk in patients with type 2 diabetes mellitus among north Indian population: A case-control study

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