Decreased BDNF, trkB-TK+ and GAD₆₇ mRNA expression in the hippocampus of individuals with schizophrenia and mood disorders

A “double hit” murine model for schizophrenia shows alterations in the structure and neurochemistry of the medial prefrontal cortex and the hippocampus

“…In this regard, the 67-kDa isoform of glutamic acid decarboxylase (GAD67), one of the enzymes responsible of GABA synthesis, is one of the most affected molecules (See Curley et al, 2011;Akbarian and Huang, 2006;Beneyto and Lewis, 2011 for review). Reduced levels of the GAD67 mRNA in the PFC (Akbarian et al, 1995;Guidotti et al, 2000;Hashimoto et al, 2008;Torrey et al, 2005) and the hippocampus (Thompson Ray et al, 2011) are one of the most consistent findings in postmortem studies of individuals with schizophrenia. Similar decreases in GAD67 protein levels in the PFC and the hippocampus of schizophrenics have been found (Torrey et al, 2005), including those reported recently by our group (Gilabert-Juan et al, 2012).…”

A decade from discovery to therapy: Lingo-1, the dark horse in neurological and psychiatric disorders

“…Levels of TrkB mRNA were reported to be decreased in the prefrontal cortex from individuals with suicide ideation (Dwivedi et al, 2003) and in the hippocampus of patients suffering from schizophrenia and/or mood disorders (Iritani et al, 2003;Thompson Ray et al, 2011) compared to healthy controls. Mutations in TrkB have also been linked to anxiety disorders (Ernst et al, 2011) as well as susceptibility for nicotine (Beuten et al, 2007) and alcohol addiction (Xu et al, 2007).…”

Ethanol extracts from Hemerocallis citrina attenuate the decreases of brain-derived neurotrophic factor, TrkB levels in rat induced by corticosterone administration

“…Brainderived neurotrophic factor (BDNF), one of important neurotrophic factors, has also been implicated in the etiology of major depression and the mechanism of antidepressant treatment (Numakawa et al, 2010). Clinical study demonstrates that depression is associated with reduced brain BDNF and its receptor (TrkB) levels and that the reductions can be restored up to the normal value by antidepressant treatment (Thompson et al, 2011). Animal studies have also demonstrated clear evidence that BDNF signaling through TrkB is involved in the mechanisms of action of antidepressant agents (Wang et al, 2010;Kutiyanawalla et al, 2011).…”