Decreased Basal Metabolic Rate Can Be an Objective Marker for Sarcopenia and Frailty in Older Males

Soysal, Pınar; Bulut, Esra Ateş; Yavuz, İdil; Işık, Ahmet Turan

doi:10.1016/j.jamda.2018.07.001

Cited by 26 publications

(19 citation statements)

References 35 publications

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“…This is particularly important in underweight older people with low FFM (74,77) , and the situation is exacerbated in nonagenarians (78) . Indeed, two recent studies found that decreased basal metabolic rate is an objective marker for sarcopenia and frailty in older adults (78,79) . Thus, in elderly people who are underweight and have low physical activity, REE represents the greatest part of total energy expenditure (74,77) .…”

Section: Metabolic Rate Decreases With Age In Relation To Loss Of Skeletal Muscle Mass and In Clinical Conditions Of Ageingmentioning

confidence: 99%

The relationships between sarcopenic skeletal muscle loss during ageing and macronutrient metabolism, obesity and onset of diabetes

Hayhoe

Cameron

2019

Proc. Nutr. Soc.

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Skeletal muscle is integral to the metabolism and utilisation of macronutrients; however, substantial muscle loss and morphological changes occur with ageing. These are associated with loss of muscle function and accelerate rapidly from the age of 60 years, leading to the conditions of sarcopenia and frailty. As the relationship between muscle ageing and macronutrient metabolism and utilisation has seen limited research to date, this review focuses on the interactions between skeletal muscle changes during ageing, metabolism and utilisation of fat, carbohydrates and overall energy expenditure.Skeletal muscle contributes less to resting energy expenditure during ageing, potentially contributing to onset of obesity from middle age. Age-related changes to skeletal muscle lead to glucose dysregulation, with consequent reduction in glycaemic control, increased insulin resistance and ultimately onset of type-2 diabetes. Recent studies indicate that high total fat and SFA intake are detrimental to skeletal muscle, while higher intakes of PUFA are protective. Age-associated changes in skeletal muscle may also reduce total fatty acid utilisation.In conclusion, further research is needed to understand the relationships between macronutrient metabolism and utilisation and age-related changes to skeletal muscle. No dietary recommendations exist specifically for skeletal muscle health during ageing, but we advise individuals to follow healthy eating guidelines, by consuming sufficient protein, fruit and vegetables, and limited SFA and to maintain physically active lifestyles. Clinicians responsible for managing type-2 diabetes need to be aware of growing evidence relating age-related skeletal muscle changes to diabetes onset and progression.

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Section: Metabolic Rate Decreases With Age In Relation To Loss Of Skeletal Muscle Mass and In Clinical Conditions Of Ageingmentioning

confidence: 99%

The relationships between sarcopenic skeletal muscle loss during ageing and macronutrient metabolism, obesity and onset of diabetes

Hayhoe

Cameron

2019

Proc. Nutr. Soc.

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“…Since the basal metabolic rate is the largest component of the total energy spent, it may provide some clues about the patient's energy metabolism, physical performance, healthy tissue mass and disability status [19]. In this study, the basal metabolic rate was not significantly different between the groups, whereas the metabolic age was significantly higher in patients with psoriasis.…”

Section: Discussionmentioning

confidence: 52%

Evaluation of Body Composition in Patients with Psoriasis

et al. 2019

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Objective: Psoriasis is a chronic inflammatory skin disease with a complex etiopathogenesis including genetic predisposition, immune dysfunction and environmental factors. Chronic inflammation leads to the development of vascular and metabolic disorders. The bioimpedance method is an easy and useful method for evaluating of body composition. In this study, it was aimed to investigate body composition, demographic, clinical and laboratory data in patients with psoriasis and to compare them with healthy controls.Material and Methods: Sociodemographic characteristics of the participants, duration of disease, concomitant systemic diseases, family history of psoriasis, presence of psoriatic arthritis and current treatments were questioned. Body composition of the participants was determined by Tanita Body Composition Analyzer type BC-418 (Tokyo, Japan), and in blood samples glucose, total cholesterol, HDL, LDL, triglyceride and insulin levels were determined by autoanalysers.Results: HOMA-IR, triglyceride, BMI, metabolic age and fat percentage were significantly higher in the psoriasis group, whereas the control group had higher body density, lean mass, mineral percentage and total body fluid. In this study, it was found that as the insulin resistance, BMI and fat ratio increased, the severity of the disease increased in patients with psoriasis. Also BMI increased in patients with longer disease duration. Topical and conventional therapies had no significant effect on laboratory and body composition parameters. Conclusion:In the light of the data obtained in this study, it was concluded that some metabolic markers and body composition parameters were negatively affected in patients with psoriasis and were associated with disease severity.

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“…If these requirements remain at about 1.7 REE in healthy elderly subjects aged about 75 years living in the community as we or others have shown previously [16,54], they are significantly decreased beyond 80 years of age below the 25th percentile PAL value of 1.49 as established by the Scientific Advisory Committee on Nutrition (SACN 2011) [55], regardless of any acute condition. A more pronounced decline in REE in very old subjects could even be a marker of frailty and sarcopenia as suggested by the results of a recent study [56]. In patients with esophageal cancer, not only was the REE not increased [57], but a low REE was also associated with worse survival at five years [58].…”

Section: Discussionmentioning

confidence: 88%

Energy Expenditure in Older People Hospitalized for an Acute Episode

et al. 2019

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Weight loss and worsening of nutritional state is a frequent downfall of acute hospitalization in older people. It is usually accepted that acute inflammation is responsible for hypercatabolism. However, several studies suggest, on the contrary, a reduction in resting energy expenditure (REE). This study aimed to obtain a reliable measure of REE and total energy expenditure (TEE) in older patients hospitalized for an acute episode in order to better assess patients’ energy requirements and help understand the mechanisms of weight loss in this situation. Nineteen hospitalized older patients (mean age 83 years) with C-reactive protein (CRP) level >20mg/L were recruited. REE and TEE were measured using gold standard methods of indirect calorimetry and doubly labeled water (DLW), respectively. REE was then compared to data from a previous study on aged volunteers from nursing homes who were free of an acute stressor event. Energy requirements measured by DLW were confirmed at 1.3 × REE. Energy intake covered the needs but did not prevent weight loss in these patients. TEE was not increased in hospitalized patients and was not influenced by inflammation, while the relationship between REE and inflammation was uncertain. Our results suggest that lean mass remains the major determinant of REE in hospitalized older people and that weight loss may not be explained solely by a state of hypercatabolism.

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Decreased Basal Metabolic Rate Can Be an Objective Marker for Sarcopenia and Frailty in Older Males

Cited by 26 publications

References 35 publications

The relationships between sarcopenic skeletal muscle loss during ageing and macronutrient metabolism, obesity and onset of diabetes

The relationships between sarcopenic skeletal muscle loss during ageing and macronutrient metabolism, obesity and onset of diabetes

Evaluation of Body Composition in Patients with Psoriasis

Energy Expenditure in Older People Hospitalized for an Acute Episode

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