Decreased argyrophilic nucleolar organiser region (AgNOR) expression in Purkinje cells: first signal of neuronal damage in sudden fetal and infant death

Lavezzi, Anna Maria; Alfonsi, Graziella; Pusiol, Teresa; Matturri, Luigi

doi:10.1136/jclinpath-2015-202961

Cited by 12 publications

(9 citation statements)

References 38 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Our previous studies have reported on an array of important side effects of nicotine exposure on the developmental process of the different brainstem centers essential for life (Lavezzi, Ottaviani, Mingrone, et al., 2005; Lavezzi, Ottaviani, Matturri, 2005; Lavezzi et al., 2007; Lavezzi et al., 2013; Lavezzi, Ferrero, et al., 2016). The findings of our study add new insights to this field and highlight the fact that the altered expression of nAChR, also limited to CC, puts fetuses exposed to maternal cigarette smoking in utero, at higher risk of SIDS or SIUDS.…”

Section: Discussionmentioning

confidence: 99%

Nicotinic Receptor Abnormalities in the Cerebellar Cortex of Sudden Unexplained Fetal and Infant Death Victims—Possible Correlation With Maternal Smoking

et al. 2017

Self Cite

View full text Add to dashboard Cite

Nicotinic acetylcholine receptors (nAChRs) are cationic channels of the neuronal cell membrane, differentially expressed in the central nervous system which, when activated by endogenous acetylcholine or exogenous nicotine, are able to enhance cholinergic transmission. The aim of this study was to investigate in human perinatal age the immunohistochemical expression of the α7-nAChR subtype, given its involvement in neuronal differentiation and its significant vulnerability to the toxic effects of nicotine. Thirty fetuses (with a gestational age between 25 and 40 weeks) and 35 infants (1–6 months old), suddenly died of known (controls) and unknown causes (unexplained deaths), with smoking and nonsmoking mothers, were included in this study. A negative or low immunoexpression of α7-nAChRs, indicative of their inactivation, was observed in the granular layers of the cerebellar cortex in 66% of the sudden unexplained perinatal deaths and 11% of the controls. A high correlation was also observed between these findings and maternal smoking. Apart from the well-known adverse effects of nicotine exposure during pregnancy, it may also cause significant alterations in cerebellar cholinergic transmission in areas of the brain involved in vital functions. These events may give us insights into the pathogenetic mechanisms leading to sudden unexplained fetal and infant death.

show abstract

Section: Discussionmentioning

confidence: 99%

Nicotinic Receptor Abnormalities in the Cerebellar Cortex of Sudden Unexplained Fetal and Infant Death Victims—Possible Correlation With Maternal Smoking

et al. 2017

Self Cite

View full text Add to dashboard Cite

show abstract

“…Murgod et al reported a significant increase in the number of AgNOR in oral submucosal fibrosis and squamous cell carcinoma. Lavezzi et al used the number of AgNOR in the detection of neuronal damage in newborns. Eröz et al stated that the number of AgNOR in hair follicles increased with the effect of growth hormone.…”

Section: Discussionmentioning

confidence: 99%

The relationship of argyrophilic proteins of the nuclear‐organized regions and atopic dermatitis in children

Gündüz

Okan

Şengil

et al. 2019

Experimental Dermatology

View full text Add to dashboard Cite

Backround: The arginophilic proteins of nuclear organized regions (AgNOR), visualized with colloidal silver methods as black dots are known as AgNOR. To date, the relationship between AgNOR and cancer and inflammatory conditions has been investigated. However, there has been no report investigating the relationship between AgNOR and atopic dermatitis. The aim of this study was to investigate the relationship between atopic dermatitis and AgNOR in paediatric patients. Methods: Twenty-nine children with atopic dermatitis and 23 healthy children were included in the study. AgNOR test results were analysed prospectively. Results: The mean AgNOR number (40.19 ± 21.06) in the patient group was significantly higher than the control group (12.83 ± 10.40) (P < .001). Conclusions: This study investigated the association between AgNOR and atopic dermatitis for the first time in the literature. In the study, atopic dermatitis and AgNOR were found to be related. In the study, for the first time with the ROC analysis, AgNOR limit values with high sensitivity and specificity levels were determined in the diagnosis of atopic dermatitis.

show abstract

“…Na slici 1 apeks krivulje učestalosti AgNOR publikacija, u kojima se prvenstveno radi o tumorskoj patologiji, ukazuje na nagli porast interesa za funkciju ribosomalnih gena u onkogenezi i uvod je u istraživanje jezgrice dinamičkim molekularnim metodama na ulazu u 21. stoljeće kada dolazi do promjene definicije jezgrice. Povezivanjem oblika, strukture i funkcije AgNOR metoda ukazuje na razvoj znanstvene misli, te daje uvid u povezanost jezgrice s patološkim stanjima koja su danas opisana molekularnim metodama [76][77][78][79][80]111,[122][123][124][125][126][127][128][129][130][131][132] . Time patologija, molekularna biologija i biotehnologija dobivaju zajednički cilj istraživanja: jezgricu u bolesti, što je vidljivo i ovdje u slici 1 i 2, a u čemu među prvima sudjeluju znanstvenici Medicinskog fakulteta u Rijeci 132 .…”

Section: Grupa Za Agnor I Rezultati S Apeksomunclassified

Descriptive and functional definition of nucleolus – a pathway to cancer therapy

et al. 2016

View full text Add to dashboard Cite

Sažetak. Očekuje se da moderna terapija tumora djeluje ciljano i sveobuhvatno. U novim kliničkim ispitivanjima terapije raka primjenjuju se mali molekularni inhibitori transkripcije ribosomalnih gena i aktivatori apoptoze. Model terapije prikazan ovdje je aktivacija supresora tumora koji djeluju u domeni jezgrice. Stanice tumora pokazuju poremećaj regulacije proteina i mutaciju P53 gena koji suprimira rast. Razvoj bolesti definira terapiju. Moderna se definicija bolesti temelji na etiopatogenezi staničnog stresa u kojem sudjeluju brojne organele, uključujući jezgricu. Jezgra i jezgrica su mikroskopski oblici. Ovaj prikaz daje sažet opis onoga što se vidi kada se kaže "jezgrica". Nadalje su opisani kiseli nehistonski proteini koji se okupljaju oko transkripcijskog ustroja RNK polimeraze I te je istaknut značaj njihove vizualizacije za promjenu definicije jezgrice. Osim što je tjelešce u nukleoplazmi i subnuklearna organela, jezgrica se može vizualizirati pomoću njezinih funkcionalnih struktura -AgNOR-a. AgNOR proteini imaju ulogu u nukleolarnom stresu. Svrha ovoga teksta je raspraviti nukleolarni stres.Ključne riječi: biološki stres; bolest; karcinogeneza; stanična jezgrica; terapija Abstract. Modern tumour therapy should be target specific and comprehensive. Recent clinical trials test small molecular inhibitors of transcription of ribosomal genes and activators of apoptosis. We treatise on models of activation of the suppressors of tumour growth acting in the nucleolar domain. Tumour cells demonstrate a disordered protein regulation and mutation of P53 gene which codes for a suppressor of growth. Therapy is guided by pathogenesis. Modern disease definition is based on etiopathogenesis of cell stress, wherein participate numerous organelles, including the nucleolus. Nucleus and nucleolus are forms seen on light microscopy. This presentation focuses on the description of the visible correlate of the notion of "nucleolus". Further to this, acid non-histone proteins which gather around the transcriptional machinery of RNA polymerase I are described, and the significance of their visualisation towards the alteration of the definition of nucleolus is pointed out. Besides being a particle within the nucleoplasm and a subnuclear organelle, the nucleolus is visualized through its functional structures -the AgNORs. The AgNOR proteins have a role in nucleolar stress. The aim of this article is to discuss the nucleolar stress.

show abstract

Decreased argyrophilic nucleolar organiser region (AgNOR) expression in Purkinje cells: first signal of neuronal damage in sudden fetal and infant death

Cited by 12 publications

References 38 publications

Nicotinic Receptor Abnormalities in the Cerebellar Cortex of Sudden Unexplained Fetal and Infant Death Victims—Possible Correlation With Maternal Smoking

Nicotinic Receptor Abnormalities in the Cerebellar Cortex of Sudden Unexplained Fetal and Infant Death Victims—Possible Correlation With Maternal Smoking

The relationship of argyrophilic proteins of the nuclear‐organized regions and atopic dermatitis in children

Descriptive and functional definition of nucleolus – a pathway to cancer therapy

Contact Info

Product

Resources

About