Decreased antioxidant enzyme expression and increased oxidative damage in erosive lichen planus of the vulva

Sander, Christina S.; Cooper, Susan; Ali, Iaisha; Dean, D.; Thiele, Jens J.; Wojnarowska, Fenella

doi:10.1111/j.1471-0528.2005.00743.x

Cited by 34 publications

(57 citation statements)

References 9 publications

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“…The disease develops through antigen-presentation to CD4+ helper T-cells followed by secretion of different cytokines and activation of CD8+ cytotoxic lymphocytes. During this process, the infl ammatory cells generate various amounts of free radicals and reactive oxygen species (ROS) that damage lipids, proteins and nucleic acids in the surrounding cells (Sander et al, 2005;Khan et al, 2003). In addition keratinocytes can release ROS subsequent to stimulation by proinfl ammatory cytokines and endotoxins (Sander et al, 2005).…”

Section: Discussionmentioning

confidence: 99%

“…Increased oxidative damage and reduced antioxidant defense have been shown in LP of the skin (Sezer et al, 2007) and in the lipids, DNA and proteins that constitute lesional tissues of vulvar lichen planus (Sander et al, 2005). Nitrative and oxidative stresses have been proposed to participate in infl ammatory-mediated carcinogenesis of OLP (Chaiyarit et al, 2005;Sander et al, 2005). A recent population-based case-control investigation evaluated serum levels of antioxidant micronu-trients in patients with this disease.…”

Section: Introductionmentioning

confidence: 97%

“…Previous studies have evaluated the signifi cance of oxidative stress in different autoimmune and infl ammation-based diseases such as psoriasis and erosive lichen planus. Increased oxidative damage and reduced antioxidant defense have been shown in LP of the skin (Sezer et al, 2007) and in the lipids, DNA and proteins that constitute lesional tissues of vulvar lichen planus (Sander et al, 2005). Nitrative and oxidative stresses have been proposed to participate in infl ammatory-mediated carcinogenesis of OLP (Chaiyarit et al, 2005;Sander et al, 2005).…”

Section: Introductionmentioning

confidence: 98%

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Efficacy of purslane in the treatment of oral lichen planus

Agha‐Hosseini

Borhan-Mojabi

Monsef-Esfahani

et al. 2009

Phytotherapy Research

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This study evaluated the effectiveness of antioxidant-rich purslane in the treatment of oral lichen planus (OLP). A total of 37 biopsy-proven symptomatic OLP patients were selected for this randomized double-blind placebo-controlled trial. All subjects were divided into two groups to receive purslane (n = 20) or placebo (n = 17) for 3 months. Assessments were made at baseline, after 2 weeks and each month for 6 months, based on the visual analog scale (VAS) and clinical improvement including lesion type and size. Approximately 83% of the purslane patients showed partial to complete clinical improvement but 17% had no response. In the placebo group 17% experienced partial improvement, 73% did not respond and 10% showed worsening. According to VAS scores, a partial to complete response was observed in all purslane-treated patients, while 71%, 15% and 14% of the controls demonstrated partial response, no response and worsening of the symptoms, respectively. A significant decrease in VAS scores was seen at the end of the study period (p < 0.001). No serious side-effects occurred in either of the groups. According to our findings purslane is clinically effective in the treatment of OLP. Considering the lack of side-effects during the study period, it may be a favorable alternative treatment for OLP.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 97%

Section: Introductionmentioning

confidence: 98%

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Efficacy of purslane in the treatment of oral lichen planus

Agha‐Hosseini

Borhan-Mojabi

Monsef-Esfahani

et al. 2009

Phytotherapy Research

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“…Sirolimus was originally developed as an antifungal agent but this use was abandoned when it was discovered to have potent immunosuppressive and antiproliferative properties. It has been studied for OLP topical management in a small study [88] rapamycin solution (1mg/ml) was applied for three months twice a day in erosive OLP lesions in seven patients; although a patients gave up the study since a burning sensation for the application of sirolimus, after 3 months four patients had total resolution and two a partial remission.…”

Section: Sirolimusmentioning

confidence: 99%

Topical Therapies for Oral Lichen Planus Management and their Efficacy: A Narrative Review

Bagán

Compilato²,

Paderni³

et al. 2012

CPD

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Oral Lichen Planus (OLP) is a chronic inflammatory condition implicating T cell-mediated cytotoxicity, and involving oral mucosal surfaces. Several therapeutic regimens have been evaluated to treat OLP and pain related, but often without high level of evidence. Topical formulations are the favourite for the majority of cases; bioadhesive formulations have been considered very useful and practical for local drug delivery in oral mucosa, due to the increased residence time on the oral mucosa of the dosage forms and better therapeutic efficacy.In this narrative review, authors try to illustrate the current topical managements for OLP from the accessible literature on this topic. Steroids are very helpful in discomfort and making better quality of life: they are considered the first-line treatment even if they could cause secondary candidosis, and sometimes bad taste, nausea, dry mouth, sore throat or swollen mouth.Other substances or devices by topical administration are adopted especially when the first line approach is refractory. This is the case when retinol with its synthetic and natural analogues (retinoids), hyaluronic acid, or Aloe Vera are chosen.Recent topical applications for OLP therapy include phototherapy and low/high energy pulsing light; the treatment with extracorporeal photochemotherapy is also reasonable and promising.Finally, calcineurin inhibitors (i.e. cyclosporine, tacrolimus and pimecrolimus), antioxidant and biologics (i.e alefacept, efalizumab, basiliximab, TNF-inhibitors -infliximab, rituximab) may be alternative approaches when OLP does not respond to the standard protocols.In this scenario, there are several studies on molecules different from glucocorticosteroids, but not sufficient or statistically adequate to justify their evidence-based use in OLP; large randomized placebo controlled trials are required to evaluate the safety and effectiveness of these non conventional therapies.In conclusion, since OLP is a chronic disease and requires long-term management, the dental/medical practitioner, who treats OLP patients, needs to know the natural history of OLP, how to monitor, and how to treat, taking in account all of the available modalities conventional and not, with pros and cons.

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“…Free O2 radicals produced by inducing lipo-peroxidase cause damage to cell membrane and consequently cell apoptosis and necrosis. In one study, a decrease in antioxidant defense and a significant increase in peroxidation products and increased oxidative damage to lipids and DNA and proteins mainly within the basal cell layer of the epidermis and at the dermoepidermal junction, have been demonstrated (Sander et al 2005). One study in 2010 showed the serum level of nitritoxide and superoxide dismutase was greater than control group.…”

Section: Etiology and Pathogenesismentioning

confidence: 99%