Decreased antioxidant defence in individuals infected by the human immunodeficiency virus

Treitinger, Arício; Spada, Celso; Verdi, Júlio César Vidal; Miranda, Armand F.; Oliveira, Osvaldo Vitorino; Silveira, M. V. S.; Moriel, Patrícia; Abdalla, Dulcinéia Saes Parra

doi:10.1046/j.1365-2362.2000.00642.x

Cited by 94 publications

(60 citation statements)

References 38 publications

(20 reference statements)

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“…As oxidative stress in CD4 þ T cells is thought to be responsible for impaired proliferation in HIV þ patients (Roederer et al, 1992;Aukrust et al, 1995;Cayota et al, 1996;Müller et al, 2000), the increase in PHA-induced proliferation observed in group J might be explained by decreased oxidative stress in CD4 þ T cells. Owing to parallel changes of antioxidant defense in plasma and cells (Treitinger et al, 2000), a reduction of intracellular oxidative stress might have been detected indirectly by increased plasma antioxidant capacity in HIV þ subjects in group J (Arendt et al, 2001). In HIV þ patients who received the concentrate, PHA-induced proliferation did not change despite an increase in plasma Polyphenols in lymphocyte proliferation and apoptosis P Winkler et al antioxidant capacity (Arendt et al, 2001).…”

Section: Discussionmentioning

confidence: 99%

Lymphocyte proliferation and apoptosis in HIV-seropositive and healthy subjects during long-term ingestion of fruit juices or a fruit-vegetable-concentrate rich in polyphenols and antioxidant vitamins

et al. 2004

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Objective: We investigated whether ingestion of polyphenols from fruit juices or a fruit-vegetable- concentrate affects lymphocyte proliferation and apoptosis in human immunodeficiency virus (HIV)-seropositive (HIV+) and HIV-seronegative ( HIV-) subjects. Design: Randomized, prospective pilot intervention study. Setting: University of Bonn, Department of General Internal Medicine. Subjects: A total of 23 HIV+ subjects from the HIV outpatient clinic, 18 HIV- controls. Interventions: Subjects ingested either 1 l of fruit juice or 30 ml of fruit-vegetable- concentrate daily for 16 weeks in addition to their regular diet. Lymphocyte proliferation and apoptosis were investigated in peripheral blood mononuclear cells at baseline, during 16-weeks of intervention, and after a 6-week washout. Proliferation was assessed by H-3-thymidine incorporation and apoptosis by nuclear content as measured by flow cytometry. Results: Supplementation of fruit juices increased phytohemagglutinin-induced lymphocyte proliferation ( mitotic index) in HIV+ patients from 18 +/- 16 to 40 +/- 34 (P = 0.004) and in healthy controls from 27 +/- 16 to 51 +/- 21 ( P = 0.016). Apoptosis was not affected in HIV+ patients, but rose in healthy controls from 9710 to 34711 ( apoptotic index; P = 0.001). Intervention with concentrate did not significantly alter proliferation and apoptosis in HIV+ and HIV- subjects. Conclusions: Even though apoptosis did not change in HIV+ subjects, ingestion of polyphenol-rich fruit juices might be favorable to HIV+ patients due to enhanced proliferation, which could restore disturbances in T-cell homeostasis. In healthy controls, increased lymphocyte proliferation during juice consumption was counterbalanced by increased apoptosis

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Section: Discussionmentioning

confidence: 99%

Lymphocyte proliferation and apoptosis in HIV-seropositive and healthy subjects during long-term ingestion of fruit juices or a fruit-vegetable-concentrate rich in polyphenols and antioxidant vitamins

et al. 2004

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“…Increased oxidation results in inactivation of antiproteases, activation of MMPs, and direct damage to the lung matrix and decreases the lung's ability to repair itself (37). HIVinfected individuals have altered systemic and lung oxidant/ antioxidant balance, with decreases in antioxidant levels such as superoxide dismutase and glutathione and increases in oxidants that may result from HIV proteins (38)(39)(40)(41). Smoking may worsen the imbalance between oxidants and antioxidants in HIV-infected persons.…”

Section: Altered Antioxidant-oxidant Balancementioning

confidence: 99%

HIV and Chronic Obstructive Pulmonary Disease: Is It Worse and Why?

Morris¹,

George²,

Crothers³

et al. 2011

Proceedings of the American Thoracic Society

110

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“…Decreased antioxidant defense and increased lipid peroxidation have been described in serum from both HIV-positive individuals and AIDS patients, suggesting a disturbance of the redox equilibrium (41,42). Soluble HIV-1 trans-activator of transcription (HIV-1 Tat) has been found in supernatants of HIV-infected cells as well as in the serum of HIV-infected individuals (43)(44)(45).…”

Section: Hiv-1 Trans-activator Of Transcription Substitutes Formentioning

confidence: 99%

HIV-1 Trans-Activator of Transcription Substitutes for Oxidative Signaling in Activation-Induced T Cell Death

Gülow

Kamiński

Darvas

et al. 2005

The Journal of Immunology

108

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Termination of an immune response requires elimination of activated T lymphocytes by activation-induced cell death (AICD). In AICD, CD95 (Apo-1/Fas) ligand (L) triggers apoptosis of CD95-positive activated T lymphocytes. In AIDS patients, AICD is strongly enhanced and accelerated. We and others have previously shown that HIV-1 trans-activator of transcription (HIV-1 Tat) sensitizes T cells toward CD95-mediated apoptosis and up-regulates CD95L expression by affecting the cellular redox balance. In this study, we show that it is hydrogen peroxide (H2O2) that functions as an essential second messenger in TCR signaling. The H2O2 signal combined with simultaneous calcium (Ca2+) influx into the cytosol constitutes the minimal requirement for induction of CD95L expression. Either signal alone is insufficient. We further show that HIV-1 Tat interferes with TCR signaling and induces a H2O2 signal. H2O2 generated by HIV-1 Tat combines with CD4-dependent calcium influx and causes massive T cell apoptosis. Thus, our data provide an explanation for CD4+ T lymphocyte depletion during progression of AIDS.

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Decreased antioxidant defence in individuals infected by the human immunodeficiency virus

Abstract: These results suggest that abnormalities of antioxidant defence, mainly of SOD activity, are related to the progression of the HIV infection.

Cited by 94 publications

References 38 publications

Lymphocyte proliferation and apoptosis in HIV-seropositive and healthy subjects during long-term ingestion of fruit juices or a fruit-vegetable-concentrate rich in polyphenols and antioxidant vitamins

Lymphocyte proliferation and apoptosis in HIV-seropositive and healthy subjects during long-term ingestion of fruit juices or a fruit-vegetable-concentrate rich in polyphenols and antioxidant vitamins

HIV and Chronic Obstructive Pulmonary Disease: Is It Worse and Why?

HIV-1 Trans-Activator of Transcription Substitutes for Oxidative Signaling in Activation-Induced T Cell Death

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