Decreased antibody-dependent and spontaneous cell-mediated cytotoxicity in patients with chronic renal failure

Làng, István; Taraba, I; Petrányi, G

doi:10.1016/0165-2478(81)90003-1

Cited by 8 publications

(4 citation statements)

References 18 publications

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“…NK cells, with the ability to mediate natural resistance against tumors and viral infections [10][11][12], have been reported to be depressed in their lytic function in uremia [13][14][15]. However, other reports conflict with this finding [2,[16][17][18].…”

Section: Discussioncontrasting

confidence: 48%

“…Natural killer (NK) cell activity is a cell-mediated cytotoxic function and is known to play an important role in immunological defence mechanisms against tumors and viral infections [10][11][12]. There have been several re ports on NK cell activity in uremia, but their data are in conflict with each other [2,[13][14][15][16][17][18]. If NK cell activity is depressed in uremic patients, their susceptibility to in fection and malignancy can be explained.…”

Section: Introductionmentioning

confidence: 99%

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Depressed Natural Killer Cell Activity in Uremia

Asaka

Iida

Izumino

et al. 1988

Nephron

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We investigated the natural killer (NK) cell activity of peripheral blood mononuclear cells (PBMC) and the suppressive factor of NK cell activity in patients on maintenance hemodialysis (HD). NK cell activity was significantly lower in patients on HD than in healthy controls (20.2 ± 16.5 vs. 31.0 ± 13.2%, p < 0.01). There was no difference in NK cell activity between patients treated with cuprophane and high-permeability membrane. NK cells from patients on HD showed a poor response to interleukin-2, and uremic sera significantly suppressed NK cell activity of normal PBMC. Although urea, creatinine, methylguanidine or guanidinosuccinic acid alone did not suppress the NK cell activity of normal PBMC, the guanidino compound did so significantly. It is suggested that defective NK cell activity in uremic patients explains in part their susceptibility to malignancy and infection. The immunosuppressive effect may be exhibited by synergism or mosaic of uremic toxins.

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Section: Discussioncontrasting

confidence: 48%

Section: Introductionmentioning

confidence: 99%

Depressed Natural Killer Cell Activity in Uremia

Asaka

Iida

Izumino

et al. 1988

Nephron

View full text Add to dashboard Cite

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“…Results were heterogeneous: PBMC from some patients performed better, some identical and some worse than PBMC from HI [16]. The other two studies can hardly be interpreted as they only used phagocyte-depleted lymphocytes as effectors [17,18]. We used the EGFR as a therapeutically established target antigen.…”

Section: Discussionmentioning

confidence: 99%

“…To our knowledge, only three studies have addressed this subject. In all of them, only peripheral blood mononuclear cells (PBMC), not PMN, were investigated as effector cells, experiments were not performed with therapeutic Abs, and results were contradictory [16,17,18]. …”

Section: Introductionmentioning

confidence: 99%

Antibody-Dependent Cellular Cytotoxicity in Patients on Chronic Hemodialysis

Koch

Derer²,

Staudinger³

et al. 2013

Am J Nephrol

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Background: Antibody (Ab)-dependent cellular cytotoxicity (ADCC) is considered to be a relevant mechanism of action of Ab-based tumor therapies. However, knowledge about ADCC capacity of dialysis patients (DP) is limited. The aim of our study was to investigate if ADCC capacity of effector cells obtained from DP differed from those of healthy individuals (HI). Methods: First, we performed ADCC assays with isolated polymorphonuclear cells (PMN) and peripheral blood mononuclear cells (PBMC), mediated by the epidermal growth factor receptor Ab cetuximab or panitumumab. As cetuximab is of human IgG1 and panitumumab of human IgG2 isotype, both Abs differ in their affinity to Fcγ receptors and effector cell recruitment. Results: Using PMN as effectors, ADCC levels via panitumumab proved to be higher than via cetuximab, but did not differ between DP and HI. In contrast, IgG2-mediated ADCC with PBMC from DP was significantly enhanced compared to HI. IgG2 Abs predominantly bind to FcγRIIa. Within the PBMC, monocytes are the only cytotoxic cells physiologically expressing this receptor. ADCC experiments with isolated monocytes confirmed them to be the pivotal cells for the observed effect. Analysis of monocytes' Fc receptor expression demonstrated no difference between DP and HI, but monocytes of DP proved to be numerically increased and appeared preactivated. Conclusion: Our studies implicate that ADCC capacity is not impaired in DP and that it might particularly be reasonable to apply human IgG2 Abs as therapeutics for these patients.

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The biology of the human natural killer cell

1982

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Natural killer (NK) cells in the human are a population of large granular lymphocytes (LGL) with at least one unique surface antigen not expressed on cells of other lineages. NK-target-cell interaction appears to involve carbohydrate recognition and, following binding, the NK cells are induced to generate O2-, transmethylate membrane phospholipids, and activate phospholipase A2. Some or all of these activities trigger a cascade of events which ultimately leads to the secretion of a substance toxic to the target cell. A variety of genes controls various steps in this cytolytic pathway. There is a good deal of evidence in the mouse, and some in the human, that NK cells play a role in host surveillance against tumor development, resistance to viral infections, and, possibly, hematopoietic regulation.

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Decreased antibody-dependent and spontaneous cell-mediated cytotoxicity in patients with chronic renal failure

Cited by 8 publications

References 18 publications

Depressed Natural Killer Cell Activity in Uremia

Depressed Natural Killer Cell Activity in Uremia

Antibody-Dependent Cellular Cytotoxicity in Patients on Chronic Hemodialysis

The biology of the human natural killer cell

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