Decreased and increased cerebral regional homogeneity in early Parkinson's disease

Choe, Il-Hwan; Chung, Kyu Jin; Kim, Sung Hoon; Lim, Sabina

doi:10.1016/j.brainres.2013.06.027

Cited by 59 publications

(51 citation statements)

References 51 publications

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“…This is partially corresponded to previous researches [13,36,37], which have showed ReHo diminishment in the aforementioned regions of PDNC patients. However, in our study, we did not find significant increase of ReHo in the aforementioned regions in the PDNC group.…”

Section: Discussionsupporting

confidence: 61%

Altered regional homogeneity of prefrontal cortex in Parkinson’s disease with mild cognitive impairment

Kang

Chen

et al. 2016

Chin Neurosurg Jl

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Background: Mild cognitive impairment (MCI) is a common non-motor symptom of early Parkinson's disease (PD), but the neural mechanisms underlying it remain poorly understood. The aim of the present study was to investigate the characteristics of cognition-related brain activities in the PD patients with MCI. Methods: The brain fMRIs and cognition tests were acquired in 39 PD patients and 22 healthy controls (HC) from September 2013 to January 2015. The patients were divided into two groups: PD-MCI (n = 18) and PD with normal cognition (PDNC, n = 19). we used resting state fMRI and a regional homogeneity (ReHo) method to explore patterns of intrinsic brain activity in patients with PD-MCI as compared with PDNC subjects and HC. Results: Compared with the PDNC group, the PD-MCI group exhibited significantly increased ReHo in parts of the prefrontal cortex regions (e.g. right superior frontal gyrus, right middle frontal gyrus and orbitofrontal cortex). Compared to the HC group, a decrease of ReHo value in left thalamus was found in PD-MCI. However, this reduction was not found in the left thalamus of PDNC group, but in the above prefrontal regions (p < 0.05, with Bonferroni correction).Conclusions: These results demonstrate that the ReHo of prefrontal cortex in resting state is changed in PD patients with MCI. The presence of MCI in PD may be attributed to abnormal regional activity in prefrontal cortex regions.

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Section: Discussionsupporting

confidence: 61%

Altered regional homogeneity of prefrontal cortex in Parkinson’s disease with mild cognitive impairment

Kang

Chen

et al. 2016

Chin Neurosurg Jl

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“…Opposing changes in ReHo were also observed in PD-CN patients, where local coherence within the left hemisphere motor circuit (posterior putamen, caudate, pre/post-central gyrus) was abnormally increased, contrary to some studies (Wu et al, 2009; Choe et al, 2013; Yang et al, 2013; Li et al, 2016; Sheng et al, 2016), but decreased in the right posterior cerebellum. These changes were not related to UPDRS total motor, tremor, or PIGD scores.…”

Section: Discussionmentioning

confidence: 56%

“…In PD, ALFF and ReHo are abnormal throughout the brain including the striatum (Wu et al, 2009; Hou et al, 2014; Sheng et al, 2016; Xiang et al, 2016), frontal or sensorimotor areas (Wu et al, 2009; Skidmore et al, 2013; Yang et al, 2013; Borroni et al, 2015; Hu X. F. et al, 2015; Li et al, 2016; Xiang et al, 2016), temporal, parietal, and/or occipital cortex (Wu et al, 2009; Long et al, 2012; Choe et al, 2013; Yang et al, 2013; Zhang et al, 2013; Hu X. F. et al, 2015; Luo et al, 2015; Li et al, 2016; Sheng et al, 2016), and the cerebellum (Wu et al, 2009; Skidmore et al, 2013; Sheng et al, 2014; Chen et al, 2015). While these findings suggest extensive disturbances in both metrics, considerable discrepancies exist across studies in regional abnormalities and whether ALFF and ReHo are increased or decreased in PD relative to controls.…”

Section: Introductionmentioning

confidence: 99%

Aberrant Intrinsic Activity and Connectivity in Cognitively Normal Parkinson’s Disease

Harrington

Shen

Castillo

et al. 2017

Front. Aging Neurosci.

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Disturbances in intrinsic activity during resting-state functional MRI (rsfMRI) are common in Parkinson’s disease (PD), but have largely been studied in a priori defined subnetworks. The cognitive significance of abnormal intrinsic activity is also poorly understood, as are abnormalities that precede the onset of mild cognitive impairment. To address these limitations, we leveraged three different analytic approaches to identify disturbances in rsfMRI metrics in 31 cognitively normal PD patients (PD-CN) and 30 healthy adults. Subjects were screened for mild cognitive impairment using the Movement Disorders Society Task Force Level II criteria. Whole-brain data-driven analytic approaches first analyzed the amplitude of low-frequency intrinsic fluctuations (ALFF) and regional homogeneity (ReHo), a measure of local connectivity amongst functionally similar regions. We then examined if regional disturbances in these metrics altered functional connectivity with other brain regions. We also investigated if abnormal rsfMRI metrics in PD-CN were related to brain atrophy and executive, visual organization, and episodic memory functioning. The results revealed abnormally increased and decreased ALFF and ReHo in PD-CN patients within the default mode network (posterior cingulate, inferior parietal cortex, parahippocampus, entorhinal cortex), sensorimotor cortex (primary motor, pre/post-central gyrus), basal ganglia (putamen, caudate), and posterior cerebellar lobule VII, which mediates cognition. For default mode network regions, we also observed a compound profile of altered ALFF and ReHo. Most regional disturbances in ALFF and ReHo were associated with strengthened long-range interactions in PD-CN, notably with regions in different networks. Stronger long-range functional connectivity in PD-CN was also partly expanded to connections that were outside the networks of the control group. Abnormally increased activity and functional connectivity appeared to have a pathological, rather than compensatory influence on cognitive abilities tested in this study. Receiver operating curve analyses demonstrated excellent sensitivity (≥90%) of rsfMRI variables in distinguishing patients from controls, but poor accuracy for brain volume and cognitive variables. Altogether these results provide new insights into the topology, cognitive relevance, and sensitivity of aberrant intrinsic activity and connectivity that precedes clinically significant cognitive impairment. Longitudinal studies are needed to determine if these neurocognitive associations presage the development of future mild cognitive impairment or dementia.

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“…However, several other studies detected that the spectral range of BOLD signals was greater than 0.1 Hz, which also demonstrated consistent patterns with low-frequency fluctuations (< 0.1 Hz) (Boubela et al 2013; Van Someren 2011). Furthermore, the orbitofrontal cortex detected in IMF1 might be the key region in DPD (Choe et al 2013; Gottlich et al 2013). Hence, we speculated that the high frequency band IMF1 might be associated with some physiological significance, rather than susceptibility artifact.…”

Section: Discussionmentioning

confidence: 99%

Frequency specific brain networks in Parkinson’s disease and comorbid depression

Qian

Zhang

Zheng

et al. 2016

Brain Imaging and Behavior

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The topological organization underlying the human brain was extensively investigated using resting-state functional magnetic resonance imaging, focusing on a low frequency of signal oscillation from 0.01 to 0.1 Hz. However, the frequency specificities with regard to the topological properties of the brain networks have not been fully revealed. In this study, a novel complementary ensemble empirical mode decomposition (CEEMD) method was used to separate the fMRI time series into five characteristic oscillations with distinct frequencies. Then, the small world properties of brain networks were analyzed for each of these five oscillations in patients (n = 67) with depressed Parkinson’s disease (DPD, n = 20) , non-depressed Parkinson’s disease (NDPD, n = 47) and healthy controls (HC, n = 46). Compared with HC, the results showed decreased network efficiency in characteristic oscillations from 0.05 to 0.12 Hz and from 0.02 to 0.05 Hz for the DPD and NDPD patients, respectively. Furthermore, compared with HC, the most significant inter-group difference across five brain oscillations was found in the basal ganglia (0.01 to 0.05 Hz) and paralimbic-limbic network (0.02 to 0.22 Hz) for the DPD patients, and in the visual cortex (0.02 to 0.05 Hz) for the NDPD patients. Compared with NDPD, the DPD patients showed reduced efficiency of nodes in the basal ganglia network (0.01 to 0.05 Hz). Our results demonstrated that DPD is characterized by a disrupted topological organization in large-scale brain functional networks. Moreover, the CEEMD analysis suggested a prominent dissociation in the topological organization of brain networks between DPD and NDPD in both space and frequency domains. Our findings indicated that these characteristic oscillatory activities in different functional circuits may contribute to distinct motor and non-motor components of clinical impairments in Parkinson’s disease.Electronic supplementary materialThe online version of this article (doi:10.1007/s11682-016-9514-9) contains supplementary material, which is available to authorized users.

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Decreased and increased cerebral regional homogeneity in early Parkinson's disease

Cited by 59 publications

References 51 publications

Altered regional homogeneity of prefrontal cortex in Parkinson’s disease with mild cognitive impairment

Altered regional homogeneity of prefrontal cortex in Parkinson’s disease with mild cognitive impairment

Aberrant Intrinsic Activity and Connectivity in Cognitively Normal Parkinson’s Disease

Frequency specific brain networks in Parkinson’s disease and comorbid depression

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