Decreased activity in right-hemisphere structures involved in social cognition in siblings discordant for schizophrenia

Achával, Delfina de; Villarreal, Mirta F.; Costanzo, Elsa Y.; Douer, J.; Castro, Mariana N.; Mora, Martina C.; Nemeroff, Charles B.; Chu, Elvina M.; Bär, Karl‐Jürgen; Guinjoan, Salvador M.

doi:10.1016/j.schres.2011.11.010

Cited by 61 publications

(68 citation statements)

References 43 publications

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“…As all the pictures used in our study showed people with positive or negative emotions, there is a strong possibility that emotion selection in our task might function as a ToM task. This opinion can be validated by previous investigations (Lee et al, 2011;de Achával et al, 2012) where the right TPJ was found to have more of a role in ToM than the left TPJ. In addition, given that patients showed a delayed response time compared with controls, the processing of exposed emotional stimuli might be more difficult for them than for controls.…”

Section: Discussionsupporting

confidence: 79%

The neural basis of a deficit in abstract thinking in patients with schizophrenia

Chun

et al. 2015

Psychiatry Research: Neuroimaging

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Section: Discussionsupporting

confidence: 79%

The neural basis of a deficit in abstract thinking in patients with schizophrenia

Chun

et al. 2015

Psychiatry Research: Neuroimaging

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“…In previous facial affect fMRI studies patients with schizophrenia and their non-psychotic relatives showed limbic system hypoactivation similarities (Barbour et al, 2010;Habel et al, 2010). In one study, patients with schizophrenia and their healthy siblings reported similar reduced right hemisphere activation (de Achával et al, 2012).…”

Section: Introductionmentioning

confidence: 81%

Functional mapping of dynamic happy and fearful facial expressions in young adults with familial risk for psychosis — Oulu Brain and Mind Study

Pulkkinen

Nikkinen

Kiviniemi

et al. 2015

Schizophrenia Research

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“…Most studies describe lower activation of the core mentalizing system and impaired mentalizing ability in behavioral tasks [33][34][35]. A few studies found increased activation of brain regions associated with mentalizing [36,37] leading to the hypothesis that individuals with schizophrenia may need greater activation in these regions to achieve the same level of mentalizing proficiency, suggesting neural inefficiency. It was proposed that positive symptoms are linked to hypermentalizing and negative symptoms to hypomentalizing; positive symptoms should result in a pattern of additional emotion and intention attributions to other people, while negative symptoms should result in a lack of emotion and intention attributions [38].…”

Section: Mentalizingmentioning

confidence: 99%

Social Cognition, Negative Symptoms and Psychosocial Functioning in Schizophrenia

Madeira¹,

Caldeira²,

Bajouco³

et al. 2016

IJCNMH

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Although functional recovery could be advocated as an achievable treatment goal, many effective interventions for the treatment of psychotic symptoms, such as antipsychotic drugs, may not improve functioning. The last two decades of cognitive and clinical research on schizophrenia were a turning point for the firm acknowledgment of how relevant social cognitive deficits and negative symptoms could be in predicting psychosocial functioning. The relevance of social cognition dysfunction in schizophrenia patients' daily living is now unabated. In fact, social cognition deficits could be the most significant predictor of functionality in patients with schizophrenia, non-redundantly with neurocognition. Emerging evidence suggests that negative symptoms appear to play an indirect role, mediating the relationship between neurocognition and social cognition with functional outcomes. Further explorations of this mediating role of negative symptoms have revealed that motivational deficits appear to be particularly important in explaining the relationship between both neurocognitive and social cognitive dysfunction and functional outcomes in schizophrenia. In this paper we will address the relative contribution of two key constructs-social cognitive deficits and negative symptoms, namely how intertwined they could be in daily life functioning of patients with schizophrenia.

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Decreased activity in right-hemisphere structures involved in social cognition in siblings discordant for schizophrenia

Cited by 61 publications

References 43 publications

The neural basis of a deficit in abstract thinking in patients with schizophrenia

The neural basis of a deficit in abstract thinking in patients with schizophrenia

Functional mapping of dynamic happy and fearful facial expressions in young adults with familial risk for psychosis — Oulu Brain and Mind Study

Social Cognition, Negative Symptoms and Psychosocial Functioning in Schizophrenia

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