Decrease of the electroacupuncture-induced analgesic effects in nuclear factor-kappa B1 knockout mice

Park, Hi-Joon; Lee, Hyang-Sook; Lee, Hyejung; Yoo, Yeong‐Min; Lee, Hee Jae; Kim, Soon Ae; Leem, Kang‐Hyun; Kim, Ho-Chul; Jung-Chul, Seo; Kim, Ee-Hwa; Lim, Sabina; Chung, Joo‐Ho

doi:10.1016/s0304-3940(01)02582-4

Cited by 23 publications

(14 citation statements)

References 20 publications

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“…Acupuncture-based techniques exert their therapeutic action regulating the activity-dependent production and release of neuromodulators, neuropeptides and neurotrophins [16, 42, 43]. The analgesic effects of EA have been correlated to a decreased activity of the p38 signaling pathway in the spinal cord [44] and to an increased Nf- κ B activity [45]. Our results indicate that EA influences NGF protein levels rather than the NGF gene expression.…”

Section: Discussionmentioning

confidence: 93%

Increased Nerve Growth Factor Signaling in Sensory Neurons of Early Diabetic Rats Is Corrected by Electroacupuncture

Nori

Rocco

Florenzano

et al. 2013

Evidence-Based Complementary and Alternative Medicine

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Diabetic polyneuropathy (DPN), characterized by early hyperalgesia and increased nerve growth factor (NGF), evolves in late irreversible neuropathic symptoms with reduced NGF support to sensory neurons. Electroacupuncture (EA) modulates NGF in the peripheral nervous system, being effective for the treatment of DPN symptoms. We hypothesize that NGF plays an important pathogenic role in DPN development, while EA could be useful in the therapy of DPN by modulating NGF expression/activity. Diabetes was induced in rats by streptozotocin (STZ) injection. One week after STZ, EA was started and continued for three weeks. NGF system and hyperalgesia-related mediators were analyzed in the dorsal root ganglia (DRG) and in their spinal cord and skin innervation territories. Our results show that four weeks long diabetes increased NGF and NGF receptors and deregulated intracellular signaling mediators of DRG neurons hypersensitization; EA in diabetic rats decreased NGF and NGF receptors, normalized c-Jun N-terminal and p38 kinases activation, decreased transient receptor potential vanilloid-1 ion channel, and possibly activated the nuclear factor kappa-light-chain-enhancer of activated B cells (Nf-κB). In conclusion, NGF signaling deregulation might play an important role in the development of DPN. EA represents a supportive tool to control DPN development by modulating NGF signaling in diabetes-targeted neurons.

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Section: Discussionmentioning

confidence: 93%

Increased Nerve Growth Factor Signaling in Sensory Neurons of Early Diabetic Rats Is Corrected by Electroacupuncture

Nori

Rocco

Florenzano

et al. 2013

Evidence-Based Complementary and Alternative Medicine

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“…In the past, NFκB knockout and transgenic animal models have been extensively used to study the NFκB pathway [75]. An increased inflammatory response coupled with an increased susceptibility to opportunistic infections has been recorded [76,77], and a decrease of the electroacupuncture-induced analgesic effects has also been shown [78]. A failure to induce CRPS like symptoms in NFκB knock mice would support the hypothesis of a NFκB as a crucial factor in CRPS.…”

Section: Discussionmentioning

confidence: 99%

Applied information retrieval and multidisciplinary research: new mechanistic hypotheses in Complex Regional Pain Syndrome

Hettne

Mos

Bruijn

et al. 2007

J Biomed Discov Collaboration

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Background: Collaborative efforts of physicians and basic scientists are often necessary in the investigation of complex disorders. Difficulties can arise, however, when large amounts of information need to reviewed. Advanced information retrieval can be beneficial in combining and reviewing data obtained from the various scientific fields. In this paper, a team of investigators with varying backgrounds has applied advanced information retrieval methods, in the form of text mining and entity relationship tools, to review the current literature, with the intention to generate new insights into the molecular mechanisms underlying a complex disorder. As an example of such a disorder the Complex Regional Pain Syndrome (CRPS) was chosen. CRPS is a painful and debilitating syndrome with a complex etiology that is still unraveled for a considerable part, resulting in suboptimal diagnosis and treatment.

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“…Further studies have shown that acupuncture activates multiple analgesia systems, stimulates pain modulation systems and leads to the release of neurotransmitters such as endogenous opioids [21]. Acupuncture has also been shown to normalizes the protein expression profile of the hypothalamus caused by neuropathic pain [22,23] and to exert neuroprotective effects on dopaminergic neurons [24]. These theories, however, are not undisputed.…”

Section: Mechanisms Of Auricular Acupuncturementioning

confidence: 99%

P-Stim™ auricular electroacupuncture stimulation device for pain relief

Sator-Katzenschlager¹,

Michalek-Sauberer²

2007

Expert Review of Medical Devices

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Acupuncture is now accepted as a complementary analgesic treatment. Auricular acupuncture is a distinct form of acupuncture. Electrical stimulation of acupoints (electroacupuncture) increases the effects of acupuncture. Recently, an auricular electroacupuncture device, the P-Stim, has become available. Clinical studies in outpatients have investigated the P-Stim in chronic musculoskeletal pain and its use for minor surgery. In chronic cervical or low back pain, auricular electroacupuncture was more effective than conventional auricular acupuncture. The results in acute pain were controversial. Auricular electroacupuncture reduced pain and remifentanil consumption during oocyte aspiration when compared with conventional auricular acupuncture or a sham treatment. However, after third molar tooth extraction, auricular electroacupuncture and auricular acupuncture failed to reduce either postoperative pain or analgesic consumption. Further large-scale studies are required to evaluate the analgesic efficacy of auricular electroacupuncture.

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Decrease of the electroacupuncture-induced analgesic effects in nuclear factor-kappa B1 knockout mice

Cited by 23 publications

References 20 publications

Increased Nerve Growth Factor Signaling in Sensory Neurons of Early Diabetic Rats Is Corrected by Electroacupuncture

Increased Nerve Growth Factor Signaling in Sensory Neurons of Early Diabetic Rats Is Corrected by Electroacupuncture

Applied information retrieval and multidisciplinary research: new mechanistic hypotheses in Complex Regional Pain Syndrome

P-Stim™ auricular electroacupuncture stimulation device for pain relief

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