Decrease of the crystallinity of bone mineral in osteopetrotic rats

Dziedzic‐Goclawska, A.; Ostrowski, K.; Michalik, J.; Stachowicz, W.; Moutier, R; Toyama, Kyoko; Lamendin, H

doi:10.1016/0221-8747(79)90016-x

Cited by 13 publications

(3 citation statements)

References 21 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…These results show that bone quality not just quantity is important for strength. It will be useful to evaluate bone mass and bone strength in these same mutations after treatments such as bone marrow transplantation and CSF‐1 injections that are known to normalize bone mass as well as crystallinity and stable collagen cross‐links in these mutants (12,13) . The purpose of this study was to test the hypothesis that reduced bone resorption in one or more of these mutations results in reduced bone strength.…”

Section: Discussionmentioning

confidence: 99%

“…Pathological fractures are common in children (8) and some adults (9) with osteopetrosis in spite of increased bone mass and density (10) . Reports of short, thick, irregular collagen fibers and reduced mineral crystallinity in bones from osteopetrotic children (11) and rodents (12–14) suggest that these are related to the increased susceptibility to fracture in osteopetrosis. However, few direct measurements of physiological bone strength in osteopetrosis are available and there is at least one report of reduced bone and mineral density in bovine osteopetrosis (15) …”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Mineral Density and Bone Strength Are Dissociated in Long Bones of Rat Osteopetrotic Mutations

Tuukkanen

Koivukangas

Jämsä

et al. 2000

Journal of Bone and Mineral Research

View full text Add to dashboard Cite

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Mineral Density and Bone Strength Are Dissociated in Long Bones of Rat Osteopetrotic Mutations

Tuukkanen

Koivukangas

Jämsä

et al. 2000

Journal of Bone and Mineral Research

View full text Add to dashboard Cite

“…The concentration of these centres was also determined to be proportional to the EPR signal intensity in a dose dependent relationship (Figures 2, 3b and 4). These observations were the basis for our further studies in which stable radiation-induced paramagnetic centres were used as a kind of markers in research carried out on mineralised tissues for evaluating the crystallinity of bone mineral , 1979, 1984, the remodelling process of radiation-sterilised bone grafts (Dziedzic-Goclawska 1971;Ostrowski et al 1971;Dziedzic-Goclawska et al 1991), estimating the dose of ionising radiation absorbed by living organisms in the case of accidental exposure Ostrowski et al 1980) as well as for evaluating the absorbed dose in the course of radiation sterilisation of tissue grafts (Stachowicz et al 1972).…”

Section: Interdisciplinary Researchmentioning

confidence: 99%

Irradiation as a Safety Procedure in Tissue Banking

Dziedzic‐Goclawska

Kamiński

Uhrynowska-Tyszkiewicz

et al. 2005

Cell Tissue Banking

Self Cite

167

118

View full text Add to dashboard Cite

The Central Tissue Bank in Warsaw was established in 1963 and since then ionising radiation has been routinely applied to sterilise tissue grafts. Connective tissue grafts such as bone, cartilage, tendons, sclera, pericardium, skin, acellular dermis and amnion irradiated with a dose of 35 kGy in a (60)Co source and/or with an electron beam 10 MeV accelerator are prepared in our Tissue Bank and two other multi-tissue banks operating in Poland. Over 250,000 radiation-sterilised tissue grafts have been prepared and used in hospitals throughout Poland and no infectious disease transmission or other adverse post-transplantation reactions have been reported up to today. It should be kept in mind however, that high doses of ionising radiation can evoke numerous chemical and physical changes that may affect the biological quality of tissue allografts. Therefore, interdisciplinary research has been undertaken at the Central Tissue Bank in Warsaw to establish the origin and stability of free radicals and other paramagnetic entities induced by irradiation in bone. The effects of various preservation procedures (e.g. lyophilisation, deep-freezing) and irradiation conditions (doses, temperature of irradiation) on the osteoinductive potential and mechanical properties of bone and on the degradation of collagen, a major constituent of all connective tissue grafts, have been also studied. The results of these studies indicate that radiation-induced changes can be diminished by modification of tissue preservation methods and that, to some extent, it is possible to reduce undesired radiation-induced damage to the tissue grafts.

show abstract

Differences in the kinetics of the mineralization process in endochondral and intramembranous osteogenesis in human fetal development

Dziedzic‐Goclawska

Emerich

Grzesik

et al. 1988

Journal of Bone and Mineral Research

View full text Add to dashboard Cite

About 300 samples of bone tissue from femoral diaphyses and from parietal bones of calvaria were collected from human fetuses aged from 6-8 to 40-41 weeks in order to compare the kinetics of the mineralization process in endochondral and intramembranous bone formation. The crystallinity of bone mineral was evaluated by the method based on electron spin resonance (ESR) spectrometry, and mineral content was measured after ashing of the samples. Highly significant differences in the kinetics of deposition of mineral (ash content) and maturation of deposited mineral (crystallinity coefficient) were found between parietal bones and femoral diaphyses in the course of fetal development. In the early stages of development (6-8 to 10-12 weeks), the content of mineral and its crystallinity in parietal bones were significantly lower than in femoral diaphyses. In the parietal bones a gradual increase in both values was observed until they reached a plateau at the age of 30 weeks. On the other hand, in femoral diaphyses of 6-8-week-old fetuses mineral content was high and deposited mineral showed a high degree of crystallinity. Both these values did not change significantly until birth. The differences in kinetics of the mineralization process between the weight-bearing bones and bones that are not exposed to the influence of strong external forces are most probably genetically conditioned. The collected data supply embryological information and might be used in the future for evaluation of pathologic changes in skeletal development.

show abstract

Decrease of the crystallinity of bone mineral in osteopetrotic rats

Cited by 13 publications

References 21 publications

Mineral Density and Bone Strength Are Dissociated in Long Bones of Rat Osteopetrotic Mutations

Mineral Density and Bone Strength Are Dissociated in Long Bones of Rat Osteopetrotic Mutations

Irradiation as a Safety Procedure in Tissue Banking

Differences in the kinetics of the mineralization process in endochondral and intramembranous osteogenesis in human fetal development

Contact Info

Product

Resources

About