Decrease of Plasminogen Activator Inhibitor-1 May Contribute to the Anti-Invasive Action of Cannabidiol on Human Lung Cancer Cells

Ramer, Robert; Rohde, Anja; Merkord, Jutta; Rohde, Helga; Hinz, Burkhard

doi:10.1007/s11095-010-0219-2

Cited by 79 publications

(83 citation statements)

References 42 publications

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“…Recent studies found that Jesengsingi-Hwan prevents oxaliplatin-induced peripheral neuropathy through the functional alteration in TRPA1 and TRPM8 [116] and can reduce paclitaxel-induced peripheral neuropathy by suppressing TRPV4 expression [117]. Moreover, the TRPV1-mediated anti-cancer effects of cannabidiol have been reported in multiple cancer cell lines, including breast [118], lung [119,120], and colon [121]. Inflammatory and neuro-immune responses also play important roles in the development and progression of CIPN [122].…”

Section: Discussionmentioning

confidence: 99%

Therapeutic Effects of Phytochemicals and Medicinal Herbs on Chemotherapy-Induced Peripheral Neuropathy

Lee

Kim

2016

Molecules

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Chemotherapy-induced peripheral neuropathy (CIPN) is a frequent adverse effect of neurotoxic anticancer medicines. It leads to autonomic and somatic system dysfunction and decreases the patient's quality of life. This side effect eventually causes chemotherapy non-compliance. Patients are prompted to seek alternative treatment options since there is no conventional remedy for CIPN. A range of medicinal herbs have multifarious effects, and they have shown some evidence of efficacy in various neurological and immunological diseases. While CIPN has multiple mechanisms of neurotoxicity, these phytomedicines might offer neuronal protection or regeneration with the multiple targets in CIPN. Thus far, researchers have investigated the therapeutic benefits of several herbs, herbal formulas, and phytochemicals in preventing the onset and progress of CIPN in animals and humans. Here, we summarize current knowledge regarding the role of phytochemicals, herb extracts, and herbal formulas in alleviating CIPN.

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Section: Discussionmentioning

confidence: 99%

Therapeutic Effects of Phytochemicals and Medicinal Herbs on Chemotherapy-Induced Peripheral Neuropathy

Lee

Kim

2016

Molecules

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“…Locally produced fibrinolytic enzyme could degrade the extracellular matrix barrier and thereby facilitate local invasion and distant metastasis. [6][7][8][9] Many articles have reported that plasma D-dimer levels can be used to judge the disease stage, prognosis of many solid tumors and predict the incidence of thrombotic events in cancer patients. [3][4][5][10][11][12][13][14] Research on the application value of plasma D-dimer in colorectal cancer was carried out in the 1990s.…”

Section: Discussionmentioning

confidence: 99%

High levels of D-dimer correlated with disease status and poor prognosis of inoperable metastatic colorectal cancer patients treated with bevacizumab

Zhu¹,

Liu²,

Zhao³

et al. 2014

J Can Res Ther

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“…In certain cancer cell lines, the ability of CBD to inhibit cancer cell viability/proliferation has been reversed in the presence of antagonists for CB 2 , TRPV1, TRPM8, COX-2, and PPRγ (Table 1). Lung cancer cell lines appear to be particularly responsive to reversal of the anti-invasive effects of CBD in culture with antagonists to CB 1 , CB 2 , and TRPV1 (Ramer et al, 2010a; Ramer et al, 2010b). Currently, only two studies have investigated receptor dependence of CBD-dependent antitumor activity in vivo .…”

Section: Non-psychoactive Plant-derived Cannabinoids As Inhibitorsmentioning

confidence: 99%

The Antitumor Activity of Plant-Derived Non-Psychoactive Cannabinoids

McAllister

Soroceanu

Desprez

2015

J Neuroimmune Pharmacol

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As a therapeutic agent, most people are familiar with the palliative effects of the primary psychoactive constituent of Cannabis sativa (CS), Δ9-tetrahydrocannabinol (THC), a molecule active at both the cannabinoid 1 (CB1) and cannabinoid 2 (CB2) receptor subtypes. Through the activation primarily of CB1 receptors in the central nervous system, THC can reduce nausea, emesis and pain in cancer patients undergoing chemotherapy. During the last decade, however, several studies have now shown that CB1 and CB2 receptor agonists can act as direct antitumor agents in a variety of aggressive cancers. In addition to THC, there are many other cannabinoids found in CS, and a majority produces little to no psychoactivity due to the inability to activate cannabinoid receptors. For example, the second most abundant cannabinoid in CS is the non-psychoactive cannabidiol (CBD). Using animal models, CBD has been shown to inhibit the progression of many types of cancer including glioblastoma (GBM), breast, lung, prostate and colon cancer. This review will center on mechanisms by which CBD, and other plant-derived cannabinoids inefficient at activating cannabinoid receptors, inhibit tumor cell viability, invasion, metastasis, angiogenesis, and the stem-like potential of cancer stem cells. We will also discuss the ability of non-psychoactive cannabinoids to induce autophagy and apoptotic-mediated cancer cell death, and enhance the activity of first-line agents commonly used in cancer treatment.

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Decrease of Plasminogen Activator Inhibitor-1 May Contribute to the Anti-Invasive Action of Cannabidiol on Human Lung Cancer Cells

Abstract: Our data provide evidence for a hitherto unknown mechanism underlying the anti-invasive action of cannabidiol on human lung cancer cells.

Cited by 79 publications

References 42 publications

Therapeutic Effects of Phytochemicals and Medicinal Herbs on Chemotherapy-Induced Peripheral Neuropathy

Therapeutic Effects of Phytochemicals and Medicinal Herbs on Chemotherapy-Induced Peripheral Neuropathy

High levels of D-dimer correlated with disease status and poor prognosis of inoperable metastatic colorectal cancer patients treated with bevacizumab

The Antitumor Activity of Plant-Derived Non-Psychoactive Cannabinoids

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