Decrease of PKC precedes other cellular signs of calpain activation in area CA1 of the hippocampus after transient cerebral ischemia

Ziemka‐Nałęcz, Małgorzata; Zalewska, Teresa; Zajac, H; Domańska-Janik, Krystyna

doi:10.1016/s0197-0186(02)00096-7

Cited by 20 publications

(7 citation statements)

References 32 publications

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“…As we have reported previously, ischemia-induced changes are located in the dendritic region of CA1 pyramidal neurons of the stratum radiatum and then spread out to the stratum oriens [46]. In these regions the stress response of postinjured tissue seems to be associated with the appearance of reactive astrocytes and increased MMP activity that may facilitate delayed astrocyte-mediated tissue remodeling and repair at the periphery of the lesion.…”

Section: Discussionsupporting

confidence: 63%

The Potential Role of Metalloproteinases in Neurogenesis in the Gerbil Hippocampus Following Global Forebrain Ischemia

et al. 2011

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BackgroundMatrix metalloproteinases (MMPs) have recently been considered to be involved in the neurogenic response of adult neural stem/progenitor cells. However, there is a lack of information showing direct association between the activation of MMPs and the development of neuronal progenitor cells involving proliferation and/or further differentiation in vulnerable (Cornus Ammoni-CA1) and resistant (dentate gyrus-DG) to ischemic injury areas of the brain hippocampus.Principal FindingsWe showed that dynamics of MMPs activation in the dentate gyrus correlated closely with the rate of proliferation and differentiation of progenitor cells into mature neurons. In contrast, in the damaged CA1 pyramidal cells layer, despite the fact that some proliferating cells exhibited antigen specific characteristic of newborn neuronal cells, these did not attain maturity. This coincides with the low, near control-level, activity of MMPs. The above results are supported by our in vitro study showing that MMP inhibitors interfered with both the proliferation and differentiation of the human neural stem cell line derived from umbilical cord blood (HUCB-NSCs) toward the neuronal lineage.ConclusionTaken together, the spatial and temporal profiles of MMPs activity suggest that these proteinases could be an important component in neurogenesis-associated processes in post-ischemic brain hippocampus.

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Section: Discussionsupporting

confidence: 63%

The Potential Role of Metalloproteinases in Neurogenesis in the Gerbil Hippocampus Following Global Forebrain Ischemia

et al. 2011

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“…Studies suggest that activated PKCα can also play an important role in cell survival and growth25. Moreover, marked down regulation of PKCα and other PKC isoforms in the vulnerable CA1 hippocampal region has been observed after hippocampal ischemic injury26. Down regulation of PKCα after ischemia was not seen in damage resistant hippocampal regions.…”

Section: Discussionmentioning

confidence: 99%

Regional hippocampal differences in AKT survival signaling across the lifespan: implications for CA1 vulnerability with aging

et al. 2008

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Distinct neuronal populations differ by the degree of damage caused from cellular stress. Hippocampal neurons of area CA1 are especially vulnerable to several stressors that increase with advanced age. We show here that survival signaling, as measured by activated AKT, was significantly reduced in the nuclear CA1 region across the lifespan compared to CA3. In agreement with these findings the pro-apoptotic protein, and AKT nuclear substrate, FOXO3a was significantly higher in CA1. Further, regional differences in PHLPP1, a recently discovered inhibitor of AKT, inversely correlated with nuclear phosphorylated AKT at Ser473. Together our data suggest that regional differences in nuclear levels of activated AKT may contribute to regional differences in hippocampal vulnerability, and implicate PHLPP1 as a potential target for therapeutic intervention to improve hippocampal health.

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“…One set of enzymes that has received significant attention is the calpains, which are cytosolic cysteine proteases with variable Ca 2+ -binding domains [217]. Calpains are ubiquitously expressed in the CNS, and a clear rise in their levels has been observed in models of both transient focal and global ischaemia [272,280]. As well, activated calpains have been associated with damage to a variety of proteins [10,241,254], and calpain inhibitors have been found to provide a measure of protection in both culture [10] and in vivo models of ischaemia [12].…”

Section: Pathogenesismentioning

confidence: 99%

Tyrosine Phosphorylation of the NMDA Receptor Following Cerebral Ischaemia

Pavlov¹,

Mielke²

2012

Protein Phosphorylation in Human Health

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Decrease of PKC precedes other cellular signs of calpain activation in area CA1 of the hippocampus after transient cerebral ischemia

Cited by 20 publications

References 32 publications

The Potential Role of Metalloproteinases in Neurogenesis in the Gerbil Hippocampus Following Global Forebrain Ischemia

The Potential Role of Metalloproteinases in Neurogenesis in the Gerbil Hippocampus Following Global Forebrain Ischemia

Regional hippocampal differences in AKT survival signaling across the lifespan: implications for CA1 vulnerability with aging

Tyrosine Phosphorylation of the NMDA Receptor Following Cerebral Ischaemia

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