Decrease of hydrodynamic resistance in rat mesenteric arterioles in response to injection of polyethylene oxide polyox WSR-301

A new hydrodynamic approach by infusion of drag-reducing polymers to improve left ventricular function in rats with myocardial infarction

“…Until now, the precise mechanism that mediates the in vivo effect of DRPs has not been fully understood because of their complex fluid dynamic characters and specific viscoelastic properties. Previous studies showed that DRPs enhanced microvascular perfusion in vivo [10,27,28]. It was also found that DRPs significantly increase blood flow [29] and nearly doubled the number of functional capillaries in diabetic rats with no change in diameter [30].…”

Organic Additives for the Enhancement of Laminar Flow in a Brain‐Vessels‐Like Microchannel Assembly

“…The addition of a minute amount of additives into the blood circulatory system increases the blood velocity, tissue oxygenation, and perfusion by decreasing the vascular resistance [17,18]. This great performance is achieved without altering the blood vessels' tone [19,20], hemodynamic response of the arterioles [21,22], and rheological properties, i.e., viscosity and density, of blood [12]. Furthermore, Brands et al [23] reported the potential of the polymer additives in eliminating the particles that coagulate in the blood vessels.…”