Decrease of Estradiol and Several Lifestyle Factors, but Not &lt;b&gt;&lt;i&gt;Helicobacter pylori&lt;/i&gt;&lt;/b&gt; Infection, Are Significant Risks for Osteopenia in Japanese Females

Chinda, Daisuke; Shimoyama, Tadashi; Takikawa, Yasuhiro; Matsuzaka, Masashi; Nakaji, Shigeyuki; Fukuda, Shinsaku

doi:10.1159/000479317

Cited by 12 publications

(5 citation statements)

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“…It is clear that the primary cause of osteoporosis in women is increased bone resorption and decreased bone density as a result of decreased estrogen secretion (Chinda et al, 2017; Khosla, Atkinson, Melton, & Riggs, 1997; Zebaze et al, 2010). Meanwhile, testosterone aromatizes to estradiol in men as well.…”

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confidence: 99%

“…In Japan, many women without symptoms are found to have reduced bone mass during medical examinations and the start of treatment. However, no such medical examinations are performed for men, who are often diagnosed as having osteoporosis only after a fracture (Orimo et al, 2012).It is clear that the primary cause of osteoporosis in women is increased bone resorption and decreased bone density as a result of decreased estrogen secretion (Chinda et al, 2017;Khosla, Atkinson, Melton, & Riggs, 1997;Zebaze et al, 2010). Meanwhile, testosterone aromatizes to estradiol in men as well.…”

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Lifestyle Factors Rather Than Helicobacter pylori Infection or Estradiol Level are Associated With Osteopenia in Japanese Men

et al. 2019

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Although decreased calcium absorption, decreased bone formation, alcohol drinking, and smoking have been considered as causes of osteopenia in men, the cause is unknown in half of the cases. Many reports highlighted the association between Helicobacter pylori infection and osteoporosis, mainly in East Asia and Japan. To identify relevant factors of osteoporosis in men, we examined estrogen and calcium intakes and other lifestyle factors together with gastric mucosal atrophy caused by Helicobacter pylori infection. This study is a cross-sectional study design of 268 healthy men who underwent general medical examinations. Multivariate analysis was performed, with age, body mass index, smoking habit, drinking habit, exercise habit, estradiol level, calcium intake, and Helicobacter pylori infection and its associated gastric mucosal atrophy as the independent variables and the presence of osteopenia as the dependent variable. The adjusted odds ratio was 0.74 (95% Confidence Interval [0.29, 1.90], p = .531) and 1.31 (95% Confidence Interval [0.54, 3.21], p = .552), when Helicobacter pylori infection was positive without and with gastric mucosal atrophy, respectively. Helicobacter pylori infection and gastric mucosal atrophy were not significant factors. Low body mass index, smoking habit, and low calcium intake were significantly associated with decreased bone density. In conclusion, Helicobacter pylori infection was not a significant risk, whereas low body mass index, current smoking, and lower calcium intake had a significant influence on the development of osteopenia in men.

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Lifestyle Factors Rather Than Helicobacter pylori Infection or Estradiol Level are Associated With Osteopenia in Japanese Men

et al. 2019

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“…Vitamin D deficiency reduces the carboxylation of osteocalcin and reduces the BMC of the total body and the lumbar spine [167]. It is noteworthy that many peri-pubertal healthy adolescents have subclinical deficiency of vitamin D [105,168-170] and vitamin K2 [167,171,172]. This may be attributable to the high bone turnover in children [105,172] and the fat-restricted diet that is commonly enforced by the parents, given the fact that both vitamin D and K2 are fat-soluble vitamins.…”

Section: The Role Of Vitamin D In the Etiopathogenesis Of Adolescent mentioning

confidence: 99%

The Role of Vitamin D in the Pathogenesis of Adolescent Idiopathic Scoliosis

Ng¹,

Bettany‐Saltikov

Cheung³

et al. 2018

Asian Spine J

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Several theories have been proposed to explain the etiology of adolescent idiopathic scoliosis (AIS) until present. However, limited data are available regarding the impact of vitamin D insufficiency or deficiency on scoliosis. Previous studies have shown that vitamin D deficiency and insufficiency are prevalent in adolescents, including AIS patients. A series of studies conducted in Hong Kong have shown that as many as 30% of these patients have osteopenia. The 25-hydroxyvitamin D3 level has been found to positively correlate with bone mineral density (BMD) in healthy adolescents and negatively with Cobb angle in AIS patients; therefore, vitamin D deficiency is believed to play a role in AIS pathogenesis. This study attempts to review the relevant literature on AIS etiology to examine the association of vitamin D and various current theories. Our review suggested that vitamin D deficiency is associated with several current etiological theories of AIS. We postulate that vitamin D deficiency and/or insufficiency affects AIS development by its effect on the regulation of fibrosis, postural control, and BMD. Subclinical deficiency of vitamin K2, a fat-soluble vitamin, is also prevalent in adolescents; therefore, it is possible that the high prevalence of vitamin D deficiency is related to decreased fat intake. Further studies are required to elucidate the possible role of vitamin D in the pathogenesis and clinical management of AIS.

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“…Shih-Chun Lin conducted a retrospective study including 365 women and showed that H. pylori is related to osteoporosis in females [ 27 ], while others think that there is no correlation between them in females. Daisuke Chinda conducted a study of 473 healthy women and found that H. pylori is not a significant risk factor for osteopenia [ 28 ]. In our study, we analysed the relationship between H. pylori infection and osteoporosis.…”

Section: Discussionmentioning

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H. Pylori is related to osteoporosis but only in premenopausal female: a cross-sectional study

Wang

Dong

et al. 2020

BMC Musculoskelet Disord

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Background: Recently, an increasing number of studies have focused on the extra-gastrointestinal effects of Helicobacter pylori (H. pylori), including metabolic syndrome, fatty liver, and rheumatic and skin diseases. Osteoporosis is an asymptomatic disease that can eventually lead to fractures and has a significant impact on the quality of life of elderly individuals. Sex is an influential factor that plays a crucial role in the development of osteoporosis. The aim of this study was to investigate the relationship between H. pylori infection and osteoporosis and to identify potential influencing factors. Methods: We conducted a cross-sectional study of individuals older than 50 years old, who had undergone regular physical examinations at the Beijing Shijitan Hospital Health Examination Center from July to October 2018. We evaluated the associations of osteopenia and osteoporosis with H. pylori infection and related serum markers by using multiple linear regression and logistic regression. Then, we analysed the correlation between sex and potential serum biomarkers. Results: There were significant relationships between H. pylori infection status and bone density in premenopausal females but not in males (P = 0.381) according to Fisher's exact test. In females, H. pylori positivity (OR = 0.132, P = 0.023), Body Mass Index (BMI) (OR = 28.163, P = 0.021), and homocysteine (HCY) (OR = 17.218, P = 0.045) were associated with osteoporosis. Calcium had a trend but no statistically significant (OR = 0.060, P = 0.076) relationship with osteoporosis. Furthermore, the waist-to-hip ratio (OR = 5.783, P = 0.029), BMI (OR = 0.152, P = 0.014) and triglyceride levels (OR = 0.201, P = 0.036) were significantly different by sex, after adjusting for age as a confounder. Conclusion: H. pylori positivity, BMI and HCY are associated with osteoporosis in premenopausal females. Chronic inflammation may be involved in the relationship between H. pylori and osteoporosis.

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Decrease of Estradiol and Several Lifestyle Factors, but Not <b><i>Helicobacter pylori</i></b> Infection, Are Significant Risks for Osteopenia in Japanese Females

Cited by 12 publications

References 45 publications

Lifestyle Factors Rather Than Helicobacter pylori Infection or Estradiol Level are Associated With Osteopenia in Japanese Men

Lifestyle Factors Rather Than Helicobacter pylori Infection or Estradiol Level are Associated With Osteopenia in Japanese Men

The Role of Vitamin D in the Pathogenesis of Adolescent Idiopathic Scoliosis

H. Pylori is related to osteoporosis but only in premenopausal female: a cross-sectional study

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