Decrease of Deleted in Malignant Brain Tumour‐1 (DMBT‐1) expression is a crucial late event in intrahepatic cholangiocarcinoma

Sasaki, Motoko; Sf, Huang; Mf, Chen; Yy, Jan; Ts, Yeh; Ishikawa, Akira; Mollenhauer, Jan; Poustka, Annemarie; Tsuneyama, Koichi; Nimura, Yuji; Oda, Kazuhiro; Nakanuma, Yasuni

doi:10.1046/j.1365-2559.2003.01719.x

Cited by 17 publications

(14 citation statements)

References 20 publications

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“…DMBT1 has been implicated in epithelial differentiation and immunity. 23 Loss of DMBT1 expression was seen in astrocytoma 33 and some epithelial cancers such as lung cancer, 34 esophageal, gastric and colon cancers, 35 intrahepatic cholangiocarcinoma 36 and breast cancer. 37 Such observations have led to the proposal that DMBT1 acts as a putative tumor suppressor gene.…”

Section: Discussionmentioning

confidence: 99%

“…37 Such observations have led to the proposal that DMBT1 acts as a putative tumor suppressor gene. [33][34][35][36][37] However, upregulation of DMBT1 in gastric adenocarcinoma 23 and in some glioblastoma multiforme 38 has also been reported. Moreover, a 29 amino acid peptide corresponding to one portion of its COOH-terminus was detected in serum-free conditioned medium from some pancreatic adenocarcinoma cell lines.…”

Section: Discussionmentioning

confidence: 99%

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Differentially expressed genes in pancreatic ductal adenocarcinomas identified through serial analysis of gene expression

Hustinx¹,

Cao²,

Maitra³

et al. 2004

Cancer Biology & Therapy

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Serial analysis of gene expression (SAGE) is a powerful tool for the discovery of novel tumor markers. The publicly available online SAGE libraries of normal and neoplastic tissues (http://www.ncbi.nlm.nih.gov/SAGE/) have recently been expanded; in addition, a more complete annotation of the human genome and better biocomputational techniques have substantially improved the assignment of differentially expressed SAGE "tags" to human genes. These improvements have provided us with an opportunity to re-evaluate global gene expression in pancreatic cancer using existing SAGE libraries. SAGE libraries generated from six pancreatic cancers were compared to SAGE libraries generated from 11 non-neoplastic tissues. Compared to normal tissue libraries, we identified 453 SAGE tags as differentially expressed in pancreatic cancer, including 395 that mapped to known genes and 58 "uncharacterized" tags. Of the 395 SAGE tags assigned to known genes, 223 were overexpressed in pancreatic cancer, and 172 were underexpressed. In order to map the 58 uncharacterized differentially expressed SAGE tags to genes, we used a newly developed resource called TAGmapper (http://tagmapper.ibioinformatics.org), to identify 16 additional differentially expressed genes. The differential expression of seven genes, involved in multiple cellular processes such as signal transduction (MIC-1), differentiation (DMBT1 and Neugrin), immune response (CD74), inflammation (CXCL2), cell cycle (CEB1) and enzymatic activity (Kallikrein 6), was confirmed by either immunohistochemical labeling of tissue microarrays (Kallikrein 6, CD74 and DMBT1) or by Neugrin, MIC1 and CXCL2). Of note, Neugrin was one of the genes whose previously uncharacterized SAGE tag was correctly assigned using TAGmapper, validating the utility of this program. Novel differentially expressed genes in a cancer type can be identified by revisiting updated and expanded SAGE databases. TAGmapper should prove to be a powerful tool for the discovery of novel tumor markers through assignment of uncharacterized SAGE tags.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Differentially expressed genes in pancreatic ductal adenocarcinomas identified through serial analysis of gene expression

Hustinx¹,

Cao²,

Maitra³

et al. 2004

Cancer Biology & Therapy

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“…Indeed, deregulation of DMBT1 expression has been reported for a number of tumors, including gliomas (Lin et al, 1998), small-and non-small-cell lung cancer cell lines and tumors (Takeshita et al, 1999;Wu et al, 1999;Mollenhauer et al, 2002), carcinoma of the esophagus (Mori et al, 1999;Mollenhauer et al, 2001), epithelial skin cancer , intrahepatic cholangiocarcinoma (Sasaki et al, 2003), breast cancer (Braidotti et al, 2004;Mollenhauer et al, 2004;Blackburn et al, 2007), salivary gland tumors (Bikker et al, 2004b), pancreatic ductal adenocarcinomas (Hustinx et al, 2004;Cheung et al, 2008), oral squamous cell carcinoma (Imai et al, 2005), gastric cancer (Conde et al, 2007), and cutaneous melanoma . In many cases, expression of DMBT1/gp340/SAG was deregulated not only at the tumor site but also in flanking tissue, which could arise as a consequence of the proinflammatory environment generated by the tumor.…”

Section: A Role In Epithelial Cell Differentiation and Pathogen Recomentioning

confidence: 99%

The Conserved Scavenger Receptor Cysteine-Rich Superfamily in Therapy and Diagnosis

Moestrup²,

et al. 2011

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“…Whether an interaction occurs with the DMBT1 family of splice variants is not known, but this may be a fruitful area to explore. DMBT-1 is also reported to be downregulated in several other cancers, including skin [36], breast [37] and hepatic cholangiocarcinomas [38], to be variable, as were TFF peptide expressions, in bile duct disease [39], but upregulated in colorectal cancer [40] and biliary hepatolithiasis [41]. Such data suggest a complex interrelationship between tumorigenesis and the DMBT-1 expression patterns of any one cell type, and warrant much further investigation, including the interplay of TFF peptides.…”

Section: Ptff2 Binding To Crp-ductin and Possibly Its Splice Variantsmentioning

confidence: 99%

Trefoil factors

Otto

Thim²

2005

Cell. Mol. Life Sci.

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Trefoil factor family (TFF) peptides have many in vivo and in vitro effects on restitution, wound healing, apoptosis, cell motility, adhesion and vectorial ion pumping, amongst others. (125)I-TFF peptides bind to cell membranes with classical saturable ability. It would be surprising if there were not TFF-protein interactions that would explain these actions, but to date no convincing TFF-binding partner has been shown which unambiguously takes part in any of these functions. Nevertheless, several TFF-binding proteins exist, including the small intestinal CRP-ductin (muclin), which binds TFF2, and the recently described gastric foveolar proteins TFIZ1 (TFF1-binding) and blottin (TFF2-binding), any of which may yet interact in novel ways to elicit TFF-mediated events. This review describes the expression and, where known, the functions of such proteins.

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Decrease of Deleted in Malignant Brain Tumour‐1 (DMBT‐1) expression is a crucial late event in intrahepatic cholangiocarcinoma

Cited by 17 publications

References 20 publications

Differentially expressed genes in pancreatic ductal adenocarcinomas identified through serial analysis of gene expression

Differentially expressed genes in pancreatic ductal adenocarcinomas identified through serial analysis of gene expression

The Conserved Scavenger Receptor Cysteine-Rich Superfamily in Therapy and Diagnosis

Trefoil factors

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