Decrease of cyclin D1 in the human lung adenocarcinoma cell line A-427 by 7-hydroxycoumarin

Cytotoxic effects of mammea type coumarins from Calophyllum brasiliense

“…Mechanism of action of cytotoxic coumarins has not been investigated in detail; however, it is known that esculetin, and umbelliferone (7-hydroxycoumarin), can arrest cell cycle, and induce apoptosis (Chu et al, 2001;Jiménez-Orozco et al, 2001;Wang et al, 2002). In the case of esculetin, arrest occurs in G1 phase; it is caused by hypophosphorilation of Rb protein, downregulation of CDK4 kinase and cyclin D1, as well as upregulation of p27 inhibitor (Wang et al, 2002).…”

Potential antiproliferative effect of isoxazolo- and thiazolo coumarin derivatives on breast cancer mediated bone and lung metastases

“…7-Hydroxycoumarin has been shown to inhibit tyrosine phosphorylation in EGF-stimulated tumour cells in a time-and dosedependent manner suggesting that this eff ect may be achieved by reducing the tyrosine kinase activity of the EGF-receptor (8). In a separate study, in the absence of changes in the cyclin D1 level, mRNA/post-transcriptional eff ect was observed pointing to the PI-3K/AKT pathway (9). Some coumarins and their active metabolite 7-hydroxycoumarin analogs have shown sulfatase and aromatase inhibitory activities, which is of particular interest in breast cancer chemotherapy.…”

New dicoumarol sodium compound: crystal structure, theoretical study and tumoricidal activity against osteoblast cancer cells

“…Similarly in case of other types, like leukaemia, prostate and breast cancer, cyclin D 1 is released in an amount more than the normal levels. Coumarin and its derivatives have been proved significant antiproliferative agents by regulating the release of Cyclin D 1 [36-38]. …”