Decrease of cholesterol turnover in old rats

Hruza, Z; Wachtlová, M

doi:10.1016/0531-5565(69)90012-6

Cited by 32 publications

(6 citation statements)

References 4 publications

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“…This is consistent with such findings reported in the past as the lowering in fatty acid synthesis from glucose (29), cholesterol synthesis (30) and catabolism (31) and a decline in the activity of lipoprotein lipase (32) with aging.…”

Section: Effects Of Cytochrome C On a Tp Coenzyme A A- Lycero-phossupporting

confidence: 81%

Effects of Cytochrome C on Lipid and Sugar Metabolism in Aged Rats

Ohnishi

Tsukuda

Ogawa

1974

Japanese Journal of Pharmacology

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Results of studies on actions of cytochrome c on the liver have been reported by the authors (1-4). In a previous report (4), a conclusion was reached that the improving action exhibited by cytochrome c on spontaneously decreasing liver function in aged rats results from the improvement of mitochondrial function and an increase in hepatic glutathione.In the present study, attempts have been made to determine the effects of aging on lipid and sugar metabolism as well as the effects of cytochrome c administration of lipid and sugar metabolism in aged rats showing spontaneous decrease in liver function. MATERIALS AND METHODSThe experimental materials and methods conformed to those described in the previ ous report (4). Equine cytochrome c was given to 500 day-old rats i.nn. into thigh or p.o.in the form of enteric-coated granules in a dose of 100 mg/kg for 21 consecutive days and biochemical studies were conducted in comparison with 70 and 250 day-old rats.Method of Lipid Determination: Total serum lipids, serum cholesterol and phospho lipids were measured by means of the Bragdon's oxidation method (5), the Zurkowsky's method (6) and the Hoeflmayer and Fried's method (7) respectively, whereas free fatty acid, triglyceride and f3-lipoprotein were measured by means of the Doncomb's method (8), the Van Handel's method (9) and the heparin calcium chloride sedimentaion method (10) respectively. In determining hepatic lipids, total lipids, cholesterol, phospholipids and neutral fat were measured by the same method as used in serum determinations by extracting lipids from a homogenate prepared by adding 9 ml. of 0.9 % aqueous sodium chloride to 1 g. of the liver with the use of a mixture of chloroform and methanol (2: 1).Analysis of Fatty Acid Composition: The fatty acid composition of the serum total lipids and the hepatic total lipids were analyzed by Higasa's method (11) and Takenaka's method (12), respectively.

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Section: Effects Of Cytochrome C On a Tp Coenzyme A A- Lycero-phossupporting

confidence: 81%

Effects of Cytochrome C on Lipid and Sugar Metabolism in Aged Rats

Ohnishi

Tsukuda

Ogawa

1974

Japanese Journal of Pharmacology

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“…These lines of evidence suggest that aging rats fed beef fat may have exhibited increased rates of chain elongation by the liver due to the presence of excess fatty acids and acetyl groups and possibly mild hypoxic conditions. Cholesterol metabolism in aging rats has been studied by a few investigators (17)(18)(19)(20).…”

Section: Discussionmentioning

confidence: 99%

Dietary lipid, fatty acid synthesis and cholesterol metabolism in aging rats

Dupont

Mathias

Cabacungan

1972

Lipids

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“…Looking at PR^ as the metabolic turnover rate this finding of a decrease in turnover rate with age is supported by the report of Hruza and Wachtlova (1969), where a decrease in the metabolic turnover rate of cholesterol with age was also found.…”

Section: Lehnersupporting

confidence: 75%

Effects of age, exercise and varying thyroxine levels on cardiovascular parameters and cholesterol turnover pools of the rat

Witte

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Blood flow parameters 72 Blood pressure Peripheral resistance 82 Experiment 2: Cholesterol Final body weight Total serum cholesterol Cholesterol pools A and B Production rate of cholesterol 94 Rate constants of cholesterol Metabolic clearance of cholesterol DISCUSSION Experiment 1: Cardiovascular Final body weight Heart weight Heart rate Blood flow parameters Blood pressure Peripheral resistance 124 Experiment 2: Cholesterol 126 Final body weight Total serum cholesterol 126 Cholesterol pools A and B 130 Production rate of cholesterol 134 Rate constants and metabolic clearance of cholesterol 136

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Decrease of cholesterol turnover in old rats

Cited by 32 publications

References 4 publications

Effects of Cytochrome C on Lipid and Sugar Metabolism in Aged Rats

Effects of Cytochrome C on Lipid and Sugar Metabolism in Aged Rats

Dietary lipid, fatty acid synthesis and cholesterol metabolism in aging rats

Effects of age, exercise and varying thyroxine levels on cardiovascular parameters and cholesterol turnover pools of the rat

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