Decrease of a hepatic binding protein specific for asialoglycoproteins with accumulation of serum asialoglycoproteins in galactosamine-treated rats

Sawamura, Takaya; Kawasato, Shinobu; Shiozaki, Yasuko; Sameshima, Yoshiko; Nakada, Hiroshi; Tashiro, Yutaka

doi:10.1016/0016-5085(81)90605-3

Cited by 76 publications

(21 citation statements)

References 17 publications

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“…99m Tc-GSA bindet an den Asialoglykoproteinrezeptor (ASGPR), welcher sich spezifisch auf Lebermembranen befindet. Es wird vermutet, dass der ASGPR für den Metabolismus von Serumglykoproteinen verantwortlich ist [54]. Die hepatische Rezeptordichte ist wiederum eng mit dem Serum-ASGP-Spiegel korreliert [54].…”

Section: Nuklearmedizinische Untersuchungunclassified

“…Es wird vermutet, dass der ASGPR für den Metabolismus von Serumglykoproteinen verantwortlich ist [54]. Die hepatische Rezeptordichte ist wiederum eng mit dem Serum-ASGP-Spiegel korreliert [54]. Der theoretische Vorteil der statischen SPECT-Untersuchung liegt in der Möglichkeit der Abschätzung der regionalen Leberfunktion.…”

Section: Nuklearmedizinische Untersuchungunclassified

“…Eine Injektion von 0,5 mg / kg KG sättigt das entsprechende enzymatische System ab, sodass anschließend die Geschwindigkeit der Verstoffwechselung allein in Abhängigkeit von der Menge an und Geschwindigkeit des verstoffwechselnden Enzyms bestimmt werden kann. Diese Geschwindigkeit der Verstoffwechselung ist allerdings altersabhängig [54,55].…”

Section: Galaktose-eliminations-kapazitätunclassified

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Funktionsdiagnostik vor Leberresektion - teuer und ohne klinische Relevanz?

Kanzler

Teufel²,

Galle³

2007

Zentralbl Chir

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Hepatic failure after liver resection is a complication that is dreaded by surgeons and has a poor outcome. Inadequate functional reserve of the remaining liver parenchyma leads to the inability to regenerate and finally to the progression of liver failure. In order to predict the functional reserve of the remaining liver parenchyma, many different liver function tests have been established. Basis for most liver function assessments are metabolic liver functions such as cytochrome p450 dependent pathways or the extraction and biliary excretion of dye. Nuclear imaging of the liver parenchyma does not only allow visualisation of the liver but also accumulation of information on hepatocyte volume that might be a better predictor for the hepatic reserve and the regenerative capacity compared to the liver volume alone. However, to date no single method has been proven to be able to predict safe limits of resectability. If an underlying liver disease is excluded the resectability is mostly limited by volumetric analysis and technical feasibility of liver resection. In patients with underlying liver disease cirrhosis should be excluded. In case of liver cirrhosis, only Child-Pugh-Turcott A patients with normal bilirubin levels and without portal hypertension should be considered for liver resection.

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Section: Nuklearmedizinische Untersuchungunclassified

Section: Galaktose-eliminations-kapazitätunclassified

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Funktionsdiagnostik vor Leberresektion - teuer und ohne klinische Relevanz?

Kanzler

Teufel²,

Galle³

2007

Zentralbl Chir

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“…The ASGP receptor is only expressed by mammalian hepatocytes, and is almost always expressed on the sinusoidal and lateral surfaces of hepatocytes in the normal liver [3]. Sawamura et al [4] reported that a decrease of ASGP receptors led to accumulation of ASGP in the serum of galactosamine-treated rats. Expression of this receptor is also decreased in patients with chronic liver disease [5].…”

Section: Introductionmentioning

confidence: 98%

Usefulness of Tc-99m-GSA scintigraphy for liver surgery

et al. 2011

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Postoperative mortality remains high after hepatectomy compared with other types of surgery in patients who have cirrhosis or chronic hepatitis. Although there are several useful perioperative indicators of liver dysfunction, no standard markers are available to predict postoperative liver failure in patients with hepatocellular carcinoma (HCC) undergoing hepatectomy. The best preoperative method for evaluating the hepatic functional reserve of patients with HCC remains unclear, but technetium-99m diethylenetriamine pentaacetic acid galactosyl human serum albumin ((99m)Tc-GSA) scintigraphy is a candidate. (99m)Tc-GSA is a liver scintigraphy agent that binds to the asialoglycoprotein receptor, and can be used to assess the functional hepatocyte mass and thus determine the hepatic functional reserve in various physiological and pathological states. The maximum removal rate of (99m) Tc-GSA (GSA-Rmax) calculated by using a radiopharmacokinetic model is correlated with the severity of liver disease. There is also a significant difference of GSA-Rmax between patients with chronic hepatitis and persons with normal liver function. Regeneration of the remnant liver and recurrence of hepatitis C virus infection in the donor organ after living donor liver transplantation have also been investigated by (99m)Tc-GSA scintigraphy. This review discusses the usefulness of (99m)Tc-GSA scintigraphy for liver surgery.

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“…Recently, we have developed an analytical method of analyzing asialoglycoprotein receptors (ASGPRs) based on technetium-99m-diethylenetriaminepentaacetic acid-galactosyl human serum albumin ( 99m Tc-GSA) single photon emission computed tomography (SPECT) that can be performed readily and allows the evaluation of regional liver function or damage using an arbitrary region of interest [5][6][7]. Intravenously administered 99m Tc-GSA is taken up by ASGPRs, which are expressed abundantly on the sinusoidal surface of hepatocytes [8][9][10]. The extent of 99m Tc-GSA incorporation into the liver can be calculated objectively from the SPECT analysis, and the hepatic regional expression and density of ASGPRs are obtained.…”

Section: Introductionmentioning

confidence: 99%