Decrease in ultrasound Brain Tissue Pulsations as a potential surrogate marker of response to antidepressant

Desmidt, Thomas; Dujardin, Paul‐Armand; Brizard, Bruno; Remeniéras, Jean-Pierre; Gissot, Valérie; Dufour‐Rainfray, Diane; Atanasova, Boriana; Kazour, François; Belzung, Catherine; Camus, Vincent; El‐Hage, Wissam

doi:10.1016/j.jpsychires.2021.12.056

Cited by 5 publications

(3 citation statements)

References 20 publications

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“…Ultrasound assessments were performed at Day 0 before, during and after EMONO exposure, as well as at Day 1, by a trained investigator (PAD or BB) who was blinded for the clinical response. Ultrasound assessments consisted in measuring Brain Tissue Pulsations (BTP) according to the Tissue Pulsatility Imaging (TPI) technique which was previously used in experimental tasks involving HC and clinical populations, including participants with depression [11,12,20,21]. BTP measures were performed on an ArtUS ultrasound scanner (Telemed; Lithuania).…”

Section: Ultrasound Protocolmentioning

confidence: 99%

“…We obtained a 3D matrix of BTP: axial displacements (x, z, t) along the z axis, x axis and time t. We analyzed the temporal evolution of BTP at each position of the 2D plane. As previously described, we used two criteria to lter out artifacts and focus on physiological signals [11,12,20,21]. The rst criterion consisted in the ratio of the second maximum peak over the central peak (SMP/CP) of the temporal autocorrelation function of each kernel.…”

Section: Ultrasound Protocolmentioning

confidence: 99%

“…Other correlates of antidepressant response include changes in Brain Tissue Pulsations (BTP) as assessed with the recently developed ultrasound neuroimaging methods of Tissue Pulsatility Imaging (TPI). Indeed, ndings from our group identi ed excessive brain pulsatile movements in patients with depression [11], which are restored to safer level in responders to conventional antidepressants [12]. This ultrasound technique has the advantage to be easily implemented in various protocols such that changes in BTP can be easily investigated during gas exposure.…”

Section: Introductionmentioning

confidence: 96%

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Changes in cerebral connectivity and brain tissue pulsations with the antidepressant response to an equimolar mixture of oxygen and nitrous oxide: an MRI and ultrasound study

Desmidt,

Dujardin,

Andersson

et al. 2023

Mol Psychiatry

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Nitrous oxide (N 2 O) has recently emerged as a potential fast-acting antidepressant but the cerebral mechanisms involved in this effect remain speculative. We hypothesized that the antidepressant response to an Equimolar Mixture of Oxygen and Nitrous Oxide (EMONO) would be associated with changes in cerebral connectivity and brain tissue pulsations (BTP).Thirty participants (20 depressed and 10 healthy controls -HC) were exposed to a one-hour single session of EMONO and followed for one week. Cerebral connectivity of the Anterior Cingulate Cortex (ACC, seed based resting state blood oxygen level dependent) and BTP (as assessed with ultrasound Tissue Pulsatility Imaging) were compared before and after exposure (as well as during exposure for BTP) among HC, non-responders and responders. Response was de ned as a reduction of at least 50% in the MADRS score one week after exposure. Nine (45%) depressed participants were considered responders and eleven (55%) non-responders. In responders, we observed a signi cant reduction in the connectivity of the subgenual ACC with the precuneus. Connectivity of the supracallosal ACC with the mid-cingulate also signi cantly decreased after exposure in HC and in non-responders. BTP signi cantly increased in the 3 groups between baseline and gas exposure, but the increase in BTP within the rst ten minutes was only signi cant in responders.We found that a single session of EMONO can rapidly modify the functional connectivity in the ACC, especially in the subgenual region, which appears to contribute to the antidepressant response. In addition, larger increases in BTP, associated with a signi cant rise in cerebral blood ow, appear to promote the antidepressant response, possibly by facilitating optimal drug delivery to the brain. Our study identi ed potential cerebral mechanisms related to the antidepressant response of N 2 O, as well as potential markers for treatment response with this fast-acting antidepressant.

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Section: Ultrasound Protocolmentioning

confidence: 99%