Decrease in Serum HDL-C Level Is Associated with Elevation of Blood Pressure: Correlation Analysis from the Korean National Health and Nutrition Examination Survey 2017

Cho, Kyung‐Hyun; Park, Hye-Jeong; Kim, Jae-Ryong

doi:10.3390/ijerph17031101

Cited by 24 publications

(32 citation statements)

References 38 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Keeping BMI as low as possible in the normal range is an effective way to prevent or attenuate the development of HDL-C hypolipidemia. Consistent with the present results, Cho et al [ 46 ] also found an association between declining serum HDL-C and blood pressure and HDL-C hypolipidemia. This study also illustrated that HDL-C level in the baseline year had the greatest impact on the incidence of HDL-C hypolipidemia among all biological indicators, with HR only equal to 0.002.…”

Section: Discussionsupporting

confidence: 93%

“…One reason was that previous samples comprised the entire population, while patients with metabolic diseases in this study were screened out in the baseline year. Males were 1.258 times as likely to have HDL-C hypolipidemia as females, which is different from the results of cross-sectional studies [ 46 – 50 ]. There are two possible reasons.…”

Section: Discussioncontrasting

confidence: 72%

“…Bi et al [ 45 ] used ultrasound measurements of abdominal fat thickness to predict low HDL-C levels among Singaporean adult men and women. Drawing on the 2017 Korean National Health and Nutrition Examination Survey, Cho et al [ 46 ] found that the HDL-C level showed a weak negative correlation with blood pressure and age, with women showing a sharper decrease in HDL-C with the increase in systolic blood pressure (SBP) and age than men. Also using Korean data, Cho et al [ 47 ] found that the lowest income group showed a larger prevalence of low-HDL-C levels, and the male group showed a relatively mild decrease in the HDL-C level after mid-life.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

A cohort study on risk factors of high-density lipoprotein cholesterol hypolipidemia among urban Chinese adults

et al. 2021

View full text Add to dashboard Cite

Background High-density lipoprotein cholesterol (HDL-C) hypolipidemia, a major type of dyslipidemia, has been associated with many kinds of diseases, such as stroke, coronary heart disease, obesity and diabetes, and has displayed an increasing prevalence in China. This study explores the risk factors of HDL-C hypolipidemia and makes recommendations for controlling and preventing HDL-C hypolipidemia and the diseases caused by it. Methods Using a retrospective cohort study design, 26,863 urban adults without dyslipidemia, diabetes, cardiovascular and cerebrovascular diseases, hepatosis, renal insufficiency and thyroid diseases were enrolled in the study between 2010 and 2015. Data on each individual were collected at the 2010 baseline year and at a follow-up medical check. A Cox regression model was constructed to evaluate the influence of potential risk factors on the outcome event- HDL-C hypolipidemia. Results The incidence of HDL-C hypolipidemia was 5.7% (1531/26863). Sex, age, body mass index (BMI), HDL-C, triglyceride (TG) and urea nitrogen (UN) were significant risk factors of HDL-C hypolipidemia. Men were more likely to develop HDL-C hypolipidemia than women during follow-up medical checks (HR = 1.258, P = 0.014). The incidence of HDL-C hypolipidemia in the over 65 years old group was higher than that of the ≤65 age group (HR = 1.276, P = 0.009). The incidence of HDL-C hypolipidemia increased with increasing BMI (HR = 1.030, P = 0.002), TG (HR = 1.321, P = 0.001) and UN (HR = 1.054, P = 0.019), while falling with increasing HDL-C in the baseline year (HR = 0.002, P < 0.001). Conclusions Men, aged over 65, with high BMI were at the highest risk of developing HDL-C hypolipidemia. Measures should be taken to prevent HDL-C hypolipidemia even for healthy urban adults whose blood biochemical indicators were in the normal range when their level of TG, UN and HDL-C are closed to the border of the normal value range.

show abstract

Section: Discussionsupporting

confidence: 93%

Section: Discussioncontrasting

confidence: 72%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

A cohort study on risk factors of high-density lipoprotein cholesterol hypolipidemia among urban Chinese adults

et al. 2021

View full text Add to dashboard Cite

show abstract

“…Previous studies performed in Korea investigated the accuracy of limited numbers of equations for LDL cal [ 8 , 14 , 18 ]. In Korea, LDL Friedewald is most commonly used for LDL cal [ 8 , 24 ]. Therefore, the aim of this study was to evaluate the performance of a new LDL equation (LDL Choi ) along with previous LDL estimations using 11 equations for LDL calculation in comparison with directly measured LDL in Korean adults to improve understanding of LDL calculations when direct measurement is unavailable.…”

Section: Introductionmentioning

confidence: 99%

Validation of multiple equations for estimating low-density lipoprotein cholesterol levels in Korean adults

Choi

Park

et al. 2021

Lipids Health Dis

View full text Add to dashboard Cite

Background Limited data are available for validation of low-density lipoprotein cholesterol (LDL) calculation (LDLcal) in the adult Korean population. The aim of this study was to develop and validate a new equation for LDLcal and to compare it with previous such equations in a Korean population. Methods A new equation for LDLcal was developed (LDLChoi). LDLChoi and 11 other previously published equations were applied and compared with directly measured LDL concentration (LDLdirect) in a development cohort (population 1), an independent validation cohort in the same laboratory (population 2), and the Korea National Health and Nutrition Examination Survey 2017 cohort (population 3). Results Among the 12 equations, the newly-developed equation (LDLChoi = total cholesterol – 0.87 x high-density lipoprotein cholesterol – 0.13 x triglycerides) had the highest intraclass correlation coefficient (ICC) and the lowest mean systemic difference and median absolute percentage error in populations 1 and 2 but not in population 3. Subgroup analysis showed good agreement between LDLChoi and LDLdirect (ICC > 0.75) in population 2, whose LDLdirect < 70 mg/dL. For samples with high triglycerides (> 400 mg/dL), equation accuracy varied. Categorization concordance according to the National Cholesterol Education Program Adult Treatment Panel III criteria with the other 11 equations were less than 80%; that of LDLChoi was 87.6 and 87.4% in populations 1 and 2, respectively. Conclusions Accuracy of 12 equations for LDLcal varied by cohort and subgroup based on LDLdirect and triglycerides. A laboratory-specific equation for LDLcal and/or LDLdirect may be needed for accurate evaluation of LDL status.

show abstract

“…The average American man expects to live to 76 years of age, whereas the average woman in America expects to live to 81 years of age [27]. One possible explanation might be that the lowered HDL-C level is associated with a higher prevalence of hypertension [28] and cardiovascular events, and a lower HDL-C pattern contributes to men's elevated rates of coronary heart disease and mortality [29]. Quantity and quality of HDL are very important to suppress the incidence of metabolic disease and they could be impaired by ageing and an unhealthy lifestyle [30].…”

Section: Discussionmentioning

confidence: 99%

Rapid Decrease in HDL-C in the Puberty Period of Boys Associated with an Elevation of Blood Pressure and Dyslipidemia in Korean Teenagers: An Explanation of Why and When Men Have Lower HDL-C Levels Than Women

Cho

Kim

2021

Medical Sciences

Self Cite

View full text Add to dashboard Cite

Low serum high-density lipoproteins-cholesterol (HDL-C) levels and high blood pressure are linked to each other and are recognized as independent risk factors of cardiovascular disease and dementia. HDL can cross the blood–brain barrier to remove amyloid plaque and the blood–testis barrier to supply cholesterol for spermatogenesis, but LDL cannot. During the teenage period, between 10 and 19 years of age, the systolic blood pressure (BP) increased gradually to 7.9% in boys (p < 0.001), but not in girls (p = 0.141). The boys' group showed a remarkable decrease in the total cholesterol (TC) and HDL-C from 10 to 15 years of age (p < 0.001). After then, the TC level increased again at 19 years of age to the previous level (p < 0.001). On the other hand, the HDL-C level at 19 years of age in the boys’ group was not restored to the previous level at 10 years of age. The girls’ group maintained similar TC (p < 0.001) and HDL-C (p < 0.001) levels from 10 to 19 years of age. These results suggest there was a remarkable difference in cholesterol consumption, particularly in the HDL-C level between boys and girls during the pubertal period. Correlation analysis showed an inverse association between the HDL-C level and SBP in boys (r = −0.133, p < 0.001) and girls (r = −0.065, p = 0.009) from 10 to 19 years of age. Interestingly, only the boys’ group showed an inverse association with the diastolic BP (r = −0.122, p < 0.001); the girls’ group did not have such an association (r = −0.016, p = 0.516). In conclusion, the boys’ group showed a sharp decrease in the HDL-C level from 10 to 15 years of age, whereas the girls’ group showed an increase in the HDL-C level during the same period. These results explain why men have a lower serum HDL-C level than women in adulthood.

show abstract

Decrease in Serum HDL-C Level Is Associated with Elevation of Blood Pressure: Correlation Analysis from the Korean National Health and Nutrition Examination Survey 2017

Cited by 24 publications

References 38 publications

A cohort study on risk factors of high-density lipoprotein cholesterol hypolipidemia among urban Chinese adults

A cohort study on risk factors of high-density lipoprotein cholesterol hypolipidemia among urban Chinese adults

Validation of multiple equations for estimating low-density lipoprotein cholesterol levels in Korean adults

Rapid Decrease in HDL-C in the Puberty Period of Boys Associated with an Elevation of Blood Pressure and Dyslipidemia in Korean Teenagers: An Explanation of Why and When Men Have Lower HDL-C Levels Than Women

Contact Info

Product

Resources

About