Decrease in red cell distribution width as a useful predictor of success after catheter ablation for atrial fibrillation: a retrospective multi-center study

Yoshimoto, Issei; Inoue, Koichi; Oketani, Naoya; Ichiki, Hitoshi; Okada, Masato; Tanaka, Nobuaki; Hirao, Yuko; Oka, Takahiro; Tanaka, Kõji; Harada, Shinichi; Onishi, Toshinari; Koyama, Yasushi; Okamura, Atsunori; Iwakura, Katsuomi; Fujii, Kenshi; Miyata, Masaaki; Ohishi, Mitsuru

doi:10.1007/s00380-021-01891-2

Cited by 1 publication

(3 citation statements)

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“…Full-text manuscripts were retrieved for a detailed evaluation of nine studies. Out of them, two studies reported OR on AF recurrence based on delta NLR, 1,5 so both of them are excluded. The remaining seven studies [6][7][8][9][10][11][12] were included in our meta-analysis.…”

Section: Discussionmentioning

confidence: 99%

“…4 Although the NLR has been found to be a predictor of AF recurrence, after catheter-based ablation it does not hold the same significance for patients with acute AF who have undergone electrical conversion to sinus rhythm. 5 As our knowledge in this field advances, the NLR could potentially play a role in improving patient care and outcomes in managing AF. Therefore, the main goal of this systematic review and meta-analysis was to examine the correlation between pre-NLR and post-NLR with the recurrence of AF in postablation patients.…”

Section: Introductionmentioning

confidence: 99%

“…It effectively anticipates atrial rhythm disturbances by reflecting the role of white blood cell(WBC) dyscrasias, particularly the predominance of activated neutrophils, in arrhythmogenesis 4 . Although the NLR has been found to be a predictor of AF recurrence, after catheter‐based ablation it does not hold the same significance for patients with acute AF who have undergone electrical conversion to sinus rhythm 5 . As our knowledge in this field advances, the NLR could potentially play a role in improving patient care and outcomes in managing AF.…”

Section: Introductionmentioning

confidence: 99%

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Association between preablation and postablation neutrophil‐lymphocyte ratio and atrial fibrillation recurrence: A meta‐analysis

Lekkala,

Mellacheruvu,

Gill

et al. 2024

Journal of Arrhythmia

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Atrial fibrillation (AF) recurrence has become common in patients who have undergone catheter ablation. High neutrophil lymphocyte ratios (NLR) have been linked to an increased risk of recurrent AF. The research is, however, not conclusive. This meta‐analysis addressed the value of easily accessible and affordable pre‐ and postablation NLR levels as indicators of AF recurrence in patients who had undergone ablation. We searched PubMed, SCOPUS, and Google Scholar for pertinent studies through May 2023. Using random effects models, the aggregated odds ratio (OR) of pre‐ and post‐NLR and AF recurrence was estimated. Inter‐study heterogeneity was described using I2 statistics and leave‐one‐out sensitivity analysis. A p‐value < .05 was considered statistically significant. The literature search yielded 270 studies, seven of which were included in this meta‐analysis of 1923 patients who experienced AF recurrence after undergoing ablation. There are five retrospective and two prospective studies with a mean follow‐up of 20.5 months. The unadjusted odds ratio (OR) of AF recurrence for preablation NLR was 1.33 (95% CI: 1.04–1.71, p < .01, I2 = 95.49%), while the adjusted OR was 1.45 (95% CI: 0.87–2.43, p < .01, I2 = 95.1%). The unadjusted odds ratio (OR) for postablation NLR was 1.21 (95% CI: 1.09–1.36, p < .01, I2 = 85.9%), and the adjusted odds ratio (OR) was 1.28 (95% CI: 0.93–1.76), demonstrating significant heterogeneity (I2 = 95.32%) with a p‐value < .01. NLR was significantly associated with AF recurrence prediction. To detect AF recurrence, we recommend that clinicians add a simple NLR blood test to their diagnostic modalities.

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