Decrease in olfactory and taste receptor expression in the dorsolateral prefrontal cortex in chronic schizophrenia

Ansoleaga, Belén; Garcia‐Esparcia, Paula; Pinacho, Raquel; Haro, Josep María; Ramos, Belén; Ferrer, Isidre

doi:10.1016/j.jpsychires.2014.09.012

Cited by 58 publications

(57 citation statements)

References 87 publications

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“…, Ansoleaga et al . ). Nevertheless, their function and possible endogenous ligands are still unknown.…”

Section: Expression and Function Of Extra‐oral Bitter Taste Receptorsmentioning

confidence: 97%

“…, Ansoleaga et al . ). Therefore, if new drugs would be developed, targeting extra‐oral TAS2Rs, it is primordial that these have either specificity for a receptor with a well known and narrowly tuned expression pattern or are otherwise selectively distributed to the target tissue.…”

Section: General Conclusionmentioning

confidence: 97%

“…Recently, also a human neuroblastoma cell line, SH-SY5Y, was shown to be responsive to salicin, inducing neurite outgrowth in a hTAS2R16-and Erk-mediated fashion (Wolfle et al 2015b). Moreover, hTAS2R expression in the cortex of Parkinson's disease and schizophrenia patients seems to be dysregulated and might play a part in the side-effects induced by antipsychotic drugs, often bitter tasting (Garcia-Esparcia et al 2013, Ansoleaga et al 2014. Nevertheless, their function and possible endogenous ligands are still unknown.…”

Section: A Role For Bitter Taste Receptors In Bladder Contractions?mentioning

confidence: 99%

“…However, it needs to be emphasized that the wide range of expression of TAS2Rs also implicates that many off-target effects might occur. Extra-oral TAS2Rs might be responsible for many side-effects of drugs in clinical use, given that many drugs have a bitter taste (Clark et al 2012, Ansoleaga et al 2014. Therefore, if new drugs would be developed, targeting extra-oral TAS2Rs, it is primordial that these have either specificity for a receptor with a well known and narrowly tuned expression pattern or are otherwise selectively distributed to the target tissue.…”

Section: General Conclusionmentioning

confidence: 99%

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The bitter truth about bitter taste receptors: beyond sensing bitter in the oral cavity

Avau

Depoortere

2015

Acta Physiologica

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The bitter taste receptor (TAS2R)-family of G-protein-coupled receptors has been identified on the tongue as detectors of bitter taste over a decade ago. In the last few years, they have been discovered in an ever growing number of extra-oral tissues, including the airways, the gut, the brain and even the testis. In tissues that contact the exterior, protective functions for TAS2Rs have been proposed, in analogy to their function on the tongue as toxicity detector. However, TAS2Rs have also been found in internal organs, suggesting other roles for these receptors, perhaps involving as yet unidentified endogenous ligands. The current review gives an overview of the different proposed functions for TAS2Rs in tissues other than the oral cavity; from appetite regulation to the treatment of asthma, regulation of gastrointestinal motility and control of airway innate immunity.

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“…, Ansoleaga et al . ). Nevertheless, their function and possible endogenous ligands are still unknown.…”

Section: Expression and Function Of Extra‐oral Bitter Taste Receptorsmentioning

confidence: 97%

Section: General Conclusionmentioning

confidence: 97%

Section: A Role For Bitter Taste Receptors In Bladder Contractions?mentioning

confidence: 99%

Section: General Conclusionmentioning

confidence: 99%

See 2 more Smart Citations

The bitter truth about bitter taste receptors: beyond sensing bitter in the oral cavity

Avau

Depoortere

2015

Acta Physiologica

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“…However, ORs are also involved in cell movement, such as that of sperm [3,4], muscle cell adhesions [5], cytokinesis [6], and another group of nonolfactory ORs are involved in hormone secretion in the gut [7] and the renal juxtaglomerular apparatus [8]. Recently, ORs were reported to play unique functional roles in brain [9,10], skin [11], and prostate cancer cells [12,13]. However, the function of ORs in non-olfactory tissues remains largely elusive.…”

Section: Introductionmentioning

confidence: 99%

Olfactory receptor Olfr544 responding to azelaic acid regulates glucagon secretion in α-cells of mouse pancreatic islets

Kang

Bahk

Lee

et al. 2015

Biochemical and Biophysical Research Communications

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Brain‐based ranking of cognitive domains to predict schizophrenia

Karrer

Bassett

Derntl

et al. 2019

Human Brain Mapping

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Schizophrenia is a devastating brain disorder that disturbs sensory perception, motor action, and abstract thought. Its clinical phenotype implies dysfunction of various mental domains, which has motivated a series of theories regarding the underlying pathophysiology. Aiming at a predictive benchmark of a catalog of cognitive functions, we developed a data‐driven machine‐learning strategy and provide a proof of principle in a multisite clinical dataset (n = 324). Existing neuroscientific knowledge on diverse cognitive domains was first condensed into neurotopographical maps. We then examined how the ensuing meta‐analytic cognitive priors can distinguish patients and controls using brain morphology and intrinsic functional connectivity. Some affected cognitive domains supported well‐studied directions of research on auditory evaluation and social cognition. However, rarely suspected cognitive domains also emerged as disease relevant, including self‐oriented processing of bodily sensations in gustation and pain. Such algorithmic charting of the cognitive landscape can be used to make targeted recommendations for future mental health research.

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Decrease in olfactory and taste receptor expression in the dorsolateral prefrontal cortex in chronic schizophrenia

Cited by 58 publications

References 87 publications

The bitter truth about bitter taste receptors: beyond sensing bitter in the oral cavity

The bitter truth about bitter taste receptors: beyond sensing bitter in the oral cavity

Olfactory receptor Olfr544 responding to azelaic acid regulates glucagon secretion in α-cells of mouse pancreatic islets

Brain‐based ranking of cognitive domains to predict schizophrenia

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