Decrease in glomerular filtration rate in Japanese patients with type 2 diabetes is linked to atherosclerosis.

Taniwaki, Hiromichi; Nishizawà, Yoshiki; Kawagishi, Takahiko; Ishimura, Eiji; Emoto, Masanori; Okamura, Terue; Okuno, Yasuhisa; Morii, H

doi:10.2337/diacare.21.11.1848

Cited by 64 publications

(54 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…High IMT and stiffness parameter exhibited predictive multivariate odds ratios for concurrent CAD, which were further strengthened by the combination of high IMT and stiffness parameter ; therefore, in addition to the specific characteristics of stiffness parameter , as recently reviewed 4) and reported by us [20][21][22][24][25][26] , our findings suggest that the combination of arterial stiffness and IMT determined by ultrasound is a unique tool for the evaluation of atherosclerosis in type 2 diabetes.…”

Section: Discussionmentioning

confidence: 84%

“…Increased stiffness parameter of the carotid artery and/or aorta has been reported to be associated with CAD 15,[17][18][19] . We have also demonstrated that stiffness parameter is increased in diabetic patients with chronic kidney disease 20) , latent symptoms of peripheral artery disease 21) , insulin resistance 22,23) , and hypoadiponectinemia 24) . Furthermore, stiffness parameter in T2DM has been found to be, at least in part, reversibly improved by aerobic exercise 25) and the insulin sensitizer pioglitazone 26) .…”

Section: Introductionmentioning

confidence: 90%

“…There have been fewer studies of the clinical implications of stiffness parameter than of IMT. We and several other investigators have reported that stiffness parameter is associated with left ventricular function 30,31) , insulin resistance 22,23,32,33) , peripheral artery disease 21) , decreased GFR 20) , and drug treatments 15, 24-26, 34, 35) . These findings suggest the possible use of stiffness parameter as both a surrogate marker of atherosclerosis in treatment and a predictor of CAD.…”

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

The Combination of IMT and Stiffness Parameter .BETA. is Highly Associated with Concurrent Coronary Artery Disease in Type 2 Diabetes

Lee

Emoto

Teramura

et al. 2009

JAT

View full text Add to dashboard Cite

Aims:The clinical implications of stiffness of the carotid artery (CA) have not been fully clarified in the prediction of coronary artery disease (CAD), although intima-media thickness (IMT) has been established as a surrogate marker. We examined the associations of stiffness parameter (ST) and IMT with concurrent CAD. Methods: IMT and ST were measured by ultrasound in 439 nondiabetic subjects as a control and 1528 type 2 diabetic subjects (T2DM) with or without CAD in a cross-sectional study.

show abstract

Section: Discussionmentioning

confidence: 84%

Section: Introductionmentioning

confidence: 90%

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

The Combination of IMT and Stiffness Parameter .BETA. is Highly Associated with Concurrent Coronary Artery Disease in Type 2 Diabetes

Lee

Emoto

Teramura

et al. 2009

JAT

View full text Add to dashboard Cite

show abstract

“…It has previously been shown that patients with type 2 diabetes and a reduced eGFR (calculated by MDRD6 formula) have a similar degree of intrarenal vascular damage irrespective of their AER status [23]. Likewise, a decline in renal function has been reported to be associated with an increase in carotid intimalmedial thickness and an increase in intrarenal arterial resistance index [24]. Thus, not only AER, but also GFR may be a marker of generalised vascular disease.…”

Section: Discussionmentioning

confidence: 99%

Relationship between lipid profiles and kidney function in patients with type 1 diabetes

et al. 2007

View full text Add to dashboard Cite

Aims/hypothesis We studied the relationship between the lipid profile, estimated GFR (eGFR) and AER in patients with type 1 diabetes. We also assessed the association between the lipid profile and glycaemic control, obesity and hypertension in an environment free of manifest renal disease, as well as exploring how well the patients would have achieved the targets set in international guidelines. Methods A total of 2,927 adult patients who had type 1 diabetes and for whom lipid profiles were available were included from people participating in the nationwide, multicentre Finnish Diabetic Nephropathy Study (FinnDiane). eGFR was determined using the Cockcroft-Gault formula adjusted for body surface area. Results Patients with impaired renal function (eGFR <60 ml min −1 1.73 m −2 ) had higher total cholesterol, triacylglycerol and apolipoprotein B, and lower HDLcholesterol concentrations than patients with normal renal function (eGFR >90 ml min −1 1.73 m −2 ) or mildly impaired renal function (eGFR 60-90 ml min −1

show abstract

“…We (24) previously found in patients who had type 2 diabetes with and without microalbuminuria that the stiffness of the carotid artery was associated with GFR but not with albuminuria, independent of other clinical factors. For comparing the magnitude of influence of CKD on stiffness of the four different arterial segments in patients with diabetes, regional PWV values were expressed as percentages relative to the corresponding healthy control mean level and plotted against CKD stages.…”

Section: Discussionmentioning

confidence: 99%

Regional Arterial Stiffness in Patients with Type 2 Diabetes and Chronic Kidney Disease

Kimoto

Shoji

Shinohara

et al. 2006

Journal of the American Society of Nephrology

111

View full text Add to dashboard Cite

Increased arterial stiffness is an independent predictor of death from cardiovascular disease, and aortic stiffness is more predictive than stiffness of other arterial regions. Because little is known about the effect of chronic kidney disease (CKD) on regional arterial stiffness, pulse wave velocity (PWV) of four different arterial segments was measured in patients who had type 2 diabetes with and without various stages of CKD. A total of 434 patients had type 2 diabetes, and there were 192 healthy control subjects who were comparable in age and gender. GFR was estimated by the abbreviated Modification of Diet in Renal Disease equation. The patients with diabetes were classified into CKD stages by the definition of the Kidney Disease Outcomes Quality Initiative guidelines. PWV was measured in the heart-femoral, heart-carotid, heart-brachial, and femoralankle segments simultaneously using an automatic pulse wave analyzer. PWV of each arterial region was increased in patients who had diabetes without kidney damage and was increased further in a stepwise manner with the advanced stages of CKD. The increase in PWV was greater in the heart-femoral and heart-carotid regions than in the heart-brachial and femoral-ankle segments. However, after adjustment for age, BP, and other confounding factors using a multiple regression model, decreased GFR was independently associated with increased PWV of the heart-femoral region but not with PWV of other arterial segments. In type 2 diabetes, CKD was associated with increased stiffness of arteries, particularly of the aorta. The cross-sectional result may explain the increased risk for cardiovascular disease in CKD, although longitudinal studies are needed to confirm it.

show abstract

Decrease in glomerular filtration rate in Japanese patients with type 2 diabetes is linked to atherosclerosis.

Abstract: The decline in GFR in type 2 diabetic patients in the early stages of nephropathy may be due in part to atherosclerosis.

Cited by 64 publications

References 0 publications

The Combination of IMT and Stiffness Parameter .BETA. is Highly Associated with Concurrent Coronary Artery Disease in Type 2 Diabetes

The Combination of IMT and Stiffness Parameter .BETA. is Highly Associated with Concurrent Coronary Artery Disease in Type 2 Diabetes

Relationship between lipid profiles and kidney function in patients with type 1 diabetes

Regional Arterial Stiffness in Patients with Type 2 Diabetes and Chronic Kidney Disease

Contact Info

Product

Resources

About