Decrease in gamma-band auditory steady-state response in patients with treatment-resistant schizophrenia

Ogyu, Kamiyu; Matsushita, Karin; Honda, Shiori; Wada, Masataka; Tamura, Shuji; Takenouchi, Kazumasa; Tobari, Yui; Kusudo, Keisuke; Kato, Hideo; Koizumi, Teruki; Arai, Naohiro; Koreki, Akihiro; Matsui, Mié; Uchida, Hiroyuki; Fujii, Shinya; Onaya, Mitsumoto; Hirano, Yoji; Mimura, Masaru; Nakajima, Shinichiro; Noda, Yoshihiro

doi:10.1016/j.schres.2023.01.011

Cited by 9 publications

(7 citation statements)

References 72 publications

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“…Among the clinical correlates, correlations between increased 40-Hz ASSRs and elevated positive symptoms, especially auditory hallucinations (58,59), have been reported, which, however, has not been confirmed by other studies (52). In addition, Ogyu et al (60) examined whether 40-Hz ASSRs differentiated patients with ScZ who did not respond to standard antipsychotics (treatment-resistant schizophrenia [TRS]) versus a non-TRS group. Evoked power during 40-Hz ASSRs was only impaired in the TRS group compared with the control group.…”

Section: -Hz Assrs In Scz: Pattern Of Deficits and Correlations With ...mentioning

confidence: 99%

40-Hz Auditory Steady-State Responses in Schizophrenia: Toward a Mechanistic Biomarker for Circuit Dysfunctions and Early Detection and Diagnosis

Grent-‘t-Jong¹,

Brickwedde²,

Metzner³

et al. 2023

Biological Psychiatry

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Section: -Hz Assrs In Scz: Pattern Of Deficits and Correlations With ...mentioning

confidence: 99%

40-Hz Auditory Steady-State Responses in Schizophrenia: Toward a Mechanistic Biomarker for Circuit Dysfunctions and Early Detection and Diagnosis

Grent-‘t-Jong¹,

Brickwedde²,

Metzner³

et al. 2023

Biological Psychiatry

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“…For the power component of the ASSR (40 Hz), we identified six studies that did so [33,34,43,57,61]. In the case of the phase component of the ASSR (40 Hz), two studies were identified [32,66]. The aggregation of these studies produced a composite effect size estimate of d = 0.277, using a random-effect model.…”

Section: Supplementary Materialsmentioning

confidence: 99%

Auditory Steady-State Responses in Schizophrenia: An Updated Meta-Analysis

Zouaoui,

Dumais,

Lavoie

et al. 2023

Brain Sciences

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This meta-analysis investigates auditory steady-state responses (ASSRs) as potential biomarkers of schizophrenia, focusing on previously unexplored clinical populations, frequencies, and variables. We examined 37 studies, encompassing a diverse cohort of 1788 patients with schizophrenia, including 208 patients with first-episode psychosis, 281 at-risk individuals, and 1603 healthy controls. The results indicate moderate reductions in 40 Hz ASSRs in schizophrenia patients, with significantly greater reductions in first-episode psychosis patients and minimal changes in at-risk individuals. These results call into question the expected progression of ASSR alterations across all stages of schizophrenia. The analysis also revealed the sensitivity of ASSR alterations at 40 Hz to various factors, including stimulus type, level of analysis, and attentional focus. In conclusion, our research highlights ASSRs, particularly at 40 Hz, as potential biomarkers of schizophrenia, revealing varied implications across different stages of the disorder. This study enriches our understanding of ASSRs in schizophrenia, highlighting their potential diagnostic and therapeutic relevance, particularly in the early stages of the disease.

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“…Ninety participants were enrolled at Komagino Hospital, Tokyo, Japan, while 100 participants were enrolled at the Centre for Addiction and Mental Health (CAMH), Toronto, Canada, and 84 participants were enrolled at National Hospital Organization Shimofusa Psychiatric Medical Center, Chiba, Japan. These original studies were approved by the ethics committees at each site [9][10][11]. All participants were enrolled following the completion of an informed consent procedure and provided written assent.…”

Section: Participantsmentioning

confidence: 99%

“…All participants were enrolled following the completion of an informed consent procedure and provided written assent. The details of inclusion criteria and clinical assessments were described in our previous studies [9][10][11]. Patients had a diagnosis of schizophrenia or schizoaffective disorder based on the DSM-IV or DSM-5.…”

Section: Participantsmentioning

confidence: 99%

“…Nonetheless, approximately 20 to 40% of patients with schizophrenia are deemed to be resistant to rst-line antipsychotics [6,7]. While patients with treatmentresistant schizophrenia (TRS) appear to be distinct from patients who respond to rst-line antipsychotic medication [8][9][10][11][12], a group of patients referred to as treatment non-resistant schizophrenia (non-TRS), the neurobiological mechanisms of both groups of patients remains unknown.…”

Section: Introductionmentioning

confidence: 99%

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Associations Between Structural Covariance Network and Antipsychotic Treatment Response in Schizophrenia

Tsugawa,

Honda,

Noda

et al. 2023

Schizophrenia Bulletin

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Background and Hypothesis Schizophrenia is associated with widespread cortical thinning and abnormality in the structural covariance network, which may reflect connectome alterations due to treatment effect or disease progression. Notably, patients with treatment-resistant schizophrenia (TRS) have stronger and more widespread cortical thinning, but it remains unclear whether structural covariance is associated with treatment response in schizophrenia. Study Design We organized a multicenter magnetic resonance imaging study to assess structural covariance in a large population of TRS and non-TRS, who had been resistant and responsive to non-clozapine antipsychotics, respectively. Whole-brain structural covariance for cortical thickness was assessed in 102 patients with TRS, 77 patients with non-TRS, and 79 healthy controls (HC). Network-based statistics were used to examine the difference in structural covariance networks among the 3 groups. Moreover, the relationship between altered individual differentiated structural covariance and clinico-demographics was also explored. Study Results Patients with non-TRS exhibited greater structural covariance compared with HC, mainly in the fronto-temporal and fronto-occipital regions, while there were no significant differences in structural covariance between TRS and non-TRS or HC. Higher individual differentiated structural covariance was associated with lower general scores of the Positive and Negative Syndrome Scale in the non-TRS group, but not in the TRS group. Conclusions These findings suggest that reconfiguration of brain networks via coordinated cortical thinning is related to treatment response in schizophrenia. Further longitudinal studies are warranted to confirm if greater structural covariance could serve as a marker for treatment response in this disease.

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Decrease in gamma-band auditory steady-state response in patients with treatment-resistant schizophrenia

Cited by 9 publications

References 72 publications

40-Hz Auditory Steady-State Responses in Schizophrenia: Toward a Mechanistic Biomarker for Circuit Dysfunctions and Early Detection and Diagnosis

40-Hz Auditory Steady-State Responses in Schizophrenia: Toward a Mechanistic Biomarker for Circuit Dysfunctions and Early Detection and Diagnosis

Auditory Steady-State Responses in Schizophrenia: An Updated Meta-Analysis

Associations Between Structural Covariance Network and Antipsychotic Treatment Response in Schizophrenia

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