Decrease in anaerobe-related bacteraemias and increase in Bacteroides species isolation rate from 1998 to 2007: A retrospective study

Lazarovitch, Tsilia; Freimann, Sarit; Shapira, Galina; Blank, Helena

doi:10.1016/j.anaerobe.2009.09.003

Cited by 19 publications

(11 citation statements)

References 23 publications

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“…However, a high proportion of those studies did not report trends in incidence [9,11,12], analyzed a small number of patients [5] and occasionally including as cases, episodes of potential contamination of BCs [8]. Furthermore, none of those reports have expressed changes in incidence of anaerobic bacteremia through a population-based method which is required in order to reduce the selection bias.…”

Section: Introductionmentioning

confidence: 88%

“…In the last 10 years, only a limited number of series have been published specifically addressing the issue of bacteremia caused by anaerobic microorganisms [5,6,[8][9][10][11][12]. However, a high proportion of those studies did not report trends in incidence [9,11,12], analyzed a small number of patients [5] and occasionally including as cases, episodes of potential contamination of BCs [8].…”

Section: Introductionmentioning

confidence: 94%

See 1 more Smart Citation

Are incidence and epidemiology of anaerobic bacteremia really changing?

Vena

Alcalá

Fernández‐Cruz

et al. 2015

Eur J Clin Microbiol Infect Dis

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Incidence, prognosis and need of performing blood cultures for anaerobic bacteria are under debate, mainly due to the belief that the presence of anaerobes in blood can be easily suspected on clinical basis. We aimed to assess these three points in a retrospective analysis of a 10-year experience in our tertiary hospital. All episodes of significant anaerobic bacteremia diagnosed from 2003 to 2012 were included. Risk factors for mortality and clinical predictability of anaerobic bacteremia were evaluated in 113 randomly selected episodes. Overall incidence of anaerobic bacteremia was 1.2 episodes/1000 admissions, with no significant changes during the 10-year study period. B. fragilis group (38.1 %) and Clostridium spp. (13.7 %) were the most frequent isolated microorganisms. As for the clinical study, 43.4 % of the patients had a comorbidity classified as ultimately fatal or rapidly fatal according to the McCabe and Jackson scale. Clinical manifestations suggestive of anaerobic involvement were present in only 55 % of the patients. Twenty-eight patients (24.8 %) died during the hospitalization. Independent predictive factors of mortality were a high Charlson's comorbidity index and presentation with septic shock, whereas, an adequate source control of the infection was associated with a better outcome. In our centre, incidence of anaerobic bacteremia remained stable during the last decade. The routine use of anaerobic BCs seems to be adequate, since in about half of the cases anaerobes could not be suspected on clinical bases. Moreover, prompt source control of infection is essential in order to reduce mortality of patients with anaerobic bacteremia.

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Section: Introductionmentioning

confidence: 88%

Section: Introductionmentioning

confidence: 94%

Are incidence and epidemiology of anaerobic bacteremia really changing?

Vena

Alcalá

Fernández‐Cruz

et al. 2015

Eur J Clin Microbiol Infect Dis

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“…represent approximately 2.5-4.5% [162][163][164]. Although Prevotella naturally reside at different body sites, they most often gain entry into the bloodstream from oral niches.…”

Section: New Insights Into Prevotella Diversity and Medical Microbiologmentioning

confidence: 99%

New Insights into Prevotella Diversity and Medical Microbiology

Alauzet¹,

Marchandin

Lozniewski³

2010

Future Microbiol.

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In light of recent studies based on cultivation-independent methods, it appears that the diversity of Prevotella in human microbiota is greater than was previously assumed from cultivation-based studies, and that the implication of these bacteria in several human diseases was unrecognized. While some Prevotella taxa were found during opportunistic infections, changes in Prevotella abundance and diversity were discovered during dysbiosis-associated diseases. As member of the microbiota, Prevotella may also be considered as a reservoir for resistance genes. Greater knowledge on Prevotella diversity, as well as new insights into its pathogenic potential and implication in dysbiosis are expected from the use of human microbe identification microarrays, from whole-genome sequence analyse, and from the NIH Human Microbiome Project data. New approaches, including molecular-based methods, could contribute to improve the diagnosis of Prevotella infections.

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“…Anaerobic pathogens have been found to cause bacteremia in around 1-17% of positive blood cultures [2]. Although the rates of isolation fluctuate between centers and over time, in all series anaerobes make up a small but significant contribution to bacteremia [3,4]. Patient groups predisposed to anaerobic infections are those with underlying acute leukemia, and genitourinary and gastrointestinal malignancies [2].…”

Section: Victorianmentioning

confidence: 99%