Decrease in alcohol tolerance: clinical significance in alcohol dependence

Ziółkowski, Marcin; Maludzińska, E; Gruss, T; Rybakowski, Janusz; Volpicelli, Joseph R.

doi:10.1016/0376-8716(95)01131-h

Cited by 4 publications

(1 citation statement)

References 9 publications

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“…When patients with alcohol‐related problems visit a hospital, a definite diagnosis of alcohol dependence is performed from a cross‐sectional viewpoint. The acquired tolerance of the patients might have been lost at the time of the hospital visit because of their poor physical conditioning or age‐related declines (Ziolkowski et al., ). A previous factor analysis suggested that tolerance, withdrawal syndrome, and impaired control items could be identified as separate factors (Muthen et al., ).…”

Section: Discussionmentioning

confidence: 99%

Exploration of Core Symptoms for the Diagnosis of Alcohol Dependence in the ICD‐10

Yoshimura

Komoto

Higuchi

2016

Alcoholism Clin & Exp Res

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BackgroundThe classification of alcohol use disorder has changed over the past century. Now, the conceptualization of alcohol dependence is still controversial. Accumulating evidence has shown the reliability and validity for the diagnosis of alcohol dependence in the ICD‐10 and DSM‐IV. However, the meaning and association of the respective diagnostic items, which are descriptive of representative symptoms, have hardly been examined. The core symptom of substance use disorder has been debated in various situations, but has never been elucidated logically.MethodsWe consecutively registered 192 patients with alcohol‐related problems who visited our hospital for the first time during a certain period. The relations and principal components among the checked items of the ICD‐10 diagnostic criteria were examined statistically.ResultsThree diagnostic items in the ICD‐10 were strongly correlated with each other and were thought to form the core symptoms of alcohol dependence: “strong desire,” “difficulties in controlling,” and “neglect of pleasures.” One major physical phenomenon, “withdrawal,” seemed to complement the core symptoms in the diagnosis of alcohol dependence. Another physical phenomenon, “tolerance,” was demonstrated to be a relatively independent item. The principal component analysis also demonstrated that the diagnostic item “difficulties in controlling” had the maximum component loading value, followed by 2 items, “neglect of pleasures” and “strong desire.”ConclusionsThe core symptomatic elements in the diagnosis of alcohol dependence were statistically suggested in this study. Knowledge of the relations and components among the diagnostic items of alcohol dependence might also be applicable to other forms of substance use dependence and behavioral addiction.

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Section: Discussionmentioning

confidence: 99%

Exploration of Core Symptoms for the Diagnosis of Alcohol Dependence in the ICD‐10

Yoshimura

Komoto

Higuchi

2016

Alcoholism Clin & Exp Res

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Voices of the Afflicted

Erickson

1997

Alcoholism Clin & Exp Res

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Over the past 10 years, I have been privileged to conduct educational forums for audiences containing many recovering alcoholics or otherwise chemically dependent persons. In these forums about the addictive diseases and their treatment and research possibilities, significant interaction with the audience members occurs. During these interactions, certain anecdotal phenomena seem to predominate. The repetitive nature of these reports suggests the need for systematic investigation. As with editorial comments in major medical journals, observed phenomena and unanswered questions from those afflicted can be valuable in the generation of testable hypotheses. Perhaps the ideas presented herein will be useful in the development of future research on alcohol abuse and alcohol dependence.

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Alcohol and the Older Person

Crome¹

2000

Drugs and the Older Population

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Decrease in alcohol tolerance: clinical significance in alcohol dependence

Cited by 4 publications

References 9 publications

Exploration of Core Symptoms for the Diagnosis of Alcohol Dependence in the ICD‐10

Exploration of Core Symptoms for the Diagnosis of Alcohol Dependence in the ICD‐10

Voices of the Afflicted

Alcohol and the Older Person

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