Decorin Antagonizes IGF Receptor I (IGF-IR) Function by Interfering with IGF-IR Activity and Attenuating Downstream Signaling

Decorin causes autophagy in endothelial cells via Peg3

“…Specificity was confirmed by the lack of an autophagic response in the presence of equimolar amounts of biglycan protein core, the closest molecular relative of decorin. Decorin, by signaling via RTK interactions, can ameliorate the overall antitumor properties of the tumor stroma by counteracting malignant development to stymie tumor progression (5,13,24) and angiogenesis (20,23). Typically, these interactions are exclusively antagonistic.…”

“…Soluble decorin (10) now is emerging as a pan-receptor tyrosine kinase inhibitor and has a broad binding repertoire with various growth factors and a multitude of cell-surface receptors (11)(12)(13)(14)(15). Based on these unique features, we have proposed that decorin could be considered a "guardian from the matrix" in analogy to p53, which is referred to as the "guardian of the genome" (16).…”

Small leucine-rich proteoglycans orchestrate receptor crosstalk during inflammation

“…The finding that decorin, besides being a structural matrix component, acts as a signaling molecule gave rise to a new paradigm of how SLRPs regulate a host of biologic processes, such as differentiation, proliferation, migration and apoptosis. Decorin is capable of binding to four different receptor tyrosine kinases (RTKs), including the epidermal growth factor receptor (EGFR), 34 insulin-like growth factor-1 receptor (IGF-IR), [35][36][37][38] Met 39 and vascular endothelial growth factor receptor 2 (VEGFR2), 40 thereby impacting on fibrogenesis, 19 tumor growth and metastatic spreading. 12,41,42 A summary of recent data demonstrating the intricacy of decorin signaling, which links innate immunity, inflammation and tumor growth 16 is provided below.…”

Decorin Antagonizes the Angiogenic Network

“…Immunofluorescence-Immunofluorescent studies were performed as described before (53,82,83). Approximately 5 ϫ 10 4 HeLa cells were plated on 4-well chamber slides (BD Biosciences) and grown to full confluence in 10% FBS at 37°C.…”