Decorating hexahistidine-metal assemblies with tyrosine enhances the ability of proteins to pass through corneal biobarriers

pH‐Responsive Hexa‐Histidine Metal Assembly (HmA) with Enhanced Biocatalytic Cascades as the Vehicle for Glucose‐Mediated Long‐Acting Insulin Delivery

“…found an EE% of 60%. [ 42 ] According to the previously reported work [ 39 , 43 ] , the high encapsulation efficiency (EE%) of HmA can be attributed to the different interaction modes of the drugs with His 6 or Zn 2+ . Firstly, at neutral and alkaline pH values, Ins, GOx, and CAT are negatively charged and have electrostatic interactions with positively charged HmA.…”

“…Notably, the EE% of Ins by HmA was significantly higher than previously reported glucoseresponsive Ins delivery systems: Wu et al reported an EE% range of 67-75%, [41] whereas Guo et al found an EE% of 60%. [42] According to the previously reported work [39,43] , the high encapsulation efficiency (EE%) of HmA can be attributed to the different interaction modes of the drugs with His 6 or Zn 2+ . Firstly, at neutral and alkaline pH values, Ins, GOx, and CAT are negatively charged and have electrostatic interactions with positively charged HmA.…”

Emulsifying Lipiodol with pH-sensitive DOX@HmA nanoparticles for hepatocellular carcinoma TACE treatment eliminate metastasis

“…In our lab, we previously developed smart nanodrugs generated by the poly-his6-boligostyrene and zinc coordination self-assembly (HmA) strategy, which have the advantages of tumor-specific delivery, higher loading capacity, and pH-sensitive release for tumor-targeting [ 20 , 21 ]. In addition, HmA exhibits a promising ability to penetrate various biobarriers, such as cellular membranes and the corneal barrier, for delivering small molecular and protein drugs [ [22] , [23] , [24] , [25] , [26] , [27] ]. Herein, we present HmA loaded with DOX (DOX@HmA) to enhance the effects of TACE against liver cancer.…”