Decorated Peptide Nanofibers with Cu Nanoparticles: An Efficient Catalyst for the Multicomponent Synthesis of Chromeno [2, 3‐d] pyrimidin‐8‐amines, Quinazolines and 2H‐ Indazoles 

Abstract

An efficient, simple and green protocol has been developed for the synthesis of 7, 10‐diaryl‐7Hbenzo [7, 8] chromeno[2,3‐d] pyrimidin‐8‐amine, 2H‐indazole and quinazoline derivatives in the presence of decorated peptide nanofibers with Cu nanoparticles. Peptide nanofibre has been synthesised by self‐assembly technique. In this work, the effect of succinic anhydride was evaluated in two conditions: i) without adding succinic anhydride at pH 4, ii) by adding succinic anhydride at pH 5. Synthesized peptide nanofiber was characterized by 1H, 13C, DEPT NMR spectroscopies (Distortionless enhancement by polarization transfer), CHNSO, scanning electron microscopy (SEM), fluorescence spectroscopy, UV/Vis, FTIR and transmission electron microscopy (TEM).

New microsphere cobalt complex: preparation and catalytic consideration for the synthesis of some heterocyclic compounds

“…Therefore, this protocol is eco‐friendly and efficient and could be used wide for range variety of aldehyde with electron‐withdrawing and electron‐donating groups under the reaction conditions. Moreover, a plausible mechanism for the formation of chromeno [2, 3‐ d] pyrimidin‐8‐amines derivatives shown in Scheme 3 [28] …”

“…Moreover, a plausible mechanism for the formation of chromeno [2, 3-d] pyrimidin-8-amines derivatives shown in Scheme 3. [28] Reaction conditions: 4-Chlorobenzaldehyde (2 mmol), α-naphthol (1 mmol), malononitrile (1.5 mmol), ammonium acetate (2 mmol), microsphere cobalt complex, solvent (2 mL). [b] Isolated yield.…”

“…Among the solvents tested, EtOH gave the best result at 80°C. Subsequently, the reactions were carried [27] 2 2 93 255-260 [28] 3 3.5 72 208-212 [27] 4 2 88 162-165 [27] 5 3.5 78 177-180 [28] 6 1.5 95 192-196 [27] 7 1.5 76 280-284 [2][3][4][5][6][7][8] 8 1.5 70 270-275 9 1.5 93 232-235 [27] 10 3 72 270-275 [a] Reaction conditions: aldehyde (2 mmol), α-naphthol (1 mmol), malononitrile (1.5 mmol), ammonium acetate (2 mmol), microsphere cobalt complex (50 mg), EtOH (2 mL), 80°C. [b] Isolated yield.…”

A decennary update on applications of metal nanoparticles (MNPs) in the synthesis of nitrogen- and oxygen-containing heterocyclic scaffolds

“…CuNPs decorated with peptide nanobers (CuNP-PNF) catalyzed Knoevenagel condensation was reported for the synthesis of chromeno[2,3-d]pyrimidin-8-amines (154) from a-naphthol (111c), malononitrile (29a), ammonium acetate (147b) and benzaldehydes (21a) in polyethylene glycol (PEG, Scheme 66). 137 The same protocol was also explored for the synthesis of 2Hindazoles (92d) from o-bromo benzaldehydes (21b), sodium azide (66) and substituted anilines (6b) in good to excellent yields (Scheme 67). PNF was synthesized via the self-assembly technique using histidine as a building block and CuCl as the metal precursor.…”

Immobilized Na2WO4.2H2O on Arginine Modified Bentonite (Bentonite@L‐Arginine‐WO3): An Efficient and Sustainable Catalyst for the C−C Bond Formation

“…41), [27] polymers, [28] and nanofibers. [29] The approach which describes the modification of bentonite nanoclay with L-arginine (by ion-exchange reaction with L-arginine amino acid) makes it a good hetereogeneous ligand for the coordination of sodium tungstate (Scheme 1). Afterwards, the activity of nanocatalyst was applied for the CÀ C bond formation.…”