Deconstructing the contribution of sensory cues in social approach

Contestabile, Alessandro; Casarotto, Giulia; Girard, Benoı̂t; Tzanoulinou, Stamatina; Bellone, Camilla

doi:10.1111/ejn.15179

Cited by 21 publications

(24 citation statements)

References 27 publications

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“…Employing strategies capable of labelling defined LHb neuronal populations either based on their genetic profile or connectivity may represent a way to isolate LHb neuronal modules that could participate in specific facets of social interactions. The LHb directly controls monoaminergic nuclei including the dopaminergic ventral tegmental area (VTA), which is crucial for social interaction [ 48 ] (Fig. 1a, b ).…”

Section: Lateral Habenula Contribution To Innate Behavioursmentioning

confidence: 99%

Reward and aversion encoding in the lateral habenula for innate and learned behaviours

2022

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Throughout life, individuals experience a vast array of positive and aversive events that trigger adaptive behavioural responses. These events are often unpredicted and engage actions that are likely anchored on innate behavioural programs expressed by each individual member of virtually all animal species. In a second step, environmental cues, that are initially neutral, acquire value through the association with external sensory stimuli, and become instrumental to predict upcoming positive or negative events. This process ultimately prompts learned goal-directed actions allowing the pursuit of rewarding experience or the avoidance of a danger. Both innate and learned behavioural programs are evolutionarily conserved and fundamental for survival. Among the brain structures participating in the encoding of positive/negative stimuli and contributing to innate and learned behaviours is the epithalamic lateral habenula (LHb). The LHb provides top-down control of monoaminergic systems, responds to unexpected appetitive/aversive stimuli as well as external cues that predict the upcoming rewards or punishments. Accordingly, the LHb controls a number of behaviours that are innate (originating from unpredicted stimuli), and learned (stemming from predictive cues). In this review, we will discuss the progresses that rodent’s experimental work made in identifying how LHb activity governs these vital processes, and we will provide a view on how these findings integrate within a complex circuit connectivity.

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Section: Lateral Habenula Contribution To Innate Behavioursmentioning

confidence: 99%

Reward and aversion encoding in the lateral habenula for innate and learned behaviours

2022

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“…In recent three-chamber research, similar results are found. The activity from dopaminergic neurons of the ventral tegmental area was an increase when toward a juvenile mouse other than an object with social odor [38]. Thus, studies of animal experiments offer a favorable reference for exploring the IPD neural mechanism of human beings.…”

Section: Introductionmentioning

confidence: 99%

Neural Alterations in Interpersonal Distance (IPD) Cognition and Its Correlation with IPD Behavior: A Systematic Review

Huang

Izumi

2021

Brain Sciences

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Background. Interpersonal distance (IPD) plays a critical role in a human being’s social life, especially during interpersonal interaction, and IPD is non-verbal social information and not only provides silent cues but also provides a secure space for personal relationships. IPD has been a research field of neural studies from the recent decade, researches had provided behavior and neural correlates of IPD. Objectives. This review aims to summarize the experimental paradigms of IPD-neural research, to reveal the neural activity processes associated with it, and to explore the correlation between IPD-neural activity and IPD-behavior. Methods. We conducted a standardized systematic review procedure, including the formal search method be adopted to seek out any type of studies related to IPD and brain, then devised them into categories to make a systematic review. Results. 17 articles met the inclusion criteria of the review, 5 event-related potential (ERP) studies measured the amplitude and latencies of ERPs, and 12 functional magnetic resonance imaging (fMRI) studies provided the neural activation during IPD tasks. In addition, the passive IPD experimental paradigm is the main experimental paradigm for exploring neural activity in IPD cognition, with the parietal lobe, motor areas, prefrontal lobe, and amygdala being the main brain areas involved. Functional connections between the identified brain regions were found and have a moderate correlation with IPD behavior. Conclusions. This review provides the neural activity of the IPD interaction process. However, the insufficient ecological validity of IPD tasks and ignore the initiative of people in IPD interaction. Therefore, there is a large research space on this topic. The work of the current systematic review contributed to linking the external performance and inner neural activities of IPD.

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“…In a previous study (21) we suggested that similarly different patterns of transitions between SD rats and C57BL/6J mice reflect their distinct dynamics of social motivation. Accordingly, a recent study found a specifically high level of activity in dopaminergic neurons of the ventral tegmental area (VTA) during transition from object to social stimuli (30). Thus, the strain-dependent distinct patterns of transitions found by us may reflect distinct dynamics of social motivation between the strains.…”

Section: Discussionmentioning

confidence: 49%

“…Sex-dependent differences in murine social behavior have been comprehensively explored in previous studies, but this was done mainly regarding hormonal-driven aspects of social behavior (26,27), such as sexual ( 28), anxiety/aggressive (10), and parental behaviors (29). In contrast, evidence for differences in other aspects, such as social preference and social novelty preference have been reported only anecdotally, and in some cases with contradicting results (see for example 22,30). Here, we systematically explored such differences across three types of social discrimination tasks and three distinct laboratory mouse strains.…”

Section: Discussionmentioning

confidence: 99%

Sex-dependent parameters of social behavior show marked variations between distinct laboratory mouse strains and their mixed offspring

Kopachev

Netser

Wagner

2021

Preprint

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Background: The survival of individuals of gregarious species depends on their ability to properly form social interactions. In humans, atypical social behavior is a hallmark of several psychopathological conditions, such as depression and autism spectrum disorder, many of which have sex-specific manifestations. Various strains of laboratory mice are used to reveal the mechanisms mediating typical and atypical social behavior in mammals. Methods: Here we used three social discrimination tests (social preference, social novelty preference, and sex preference) to characterize social behavior in males and females of three widely used laboratory mouse strains (C57BL/6J, BALB/c, and ICR). Results: We found marked sex- and strain-specific differences in the preference exhibited by subjects in a test-dependent manner. Interestingly, we found some characteristics that were strain-dependent, while others were sex-dependent. Moreover, even in the social preference test, where both sexes of all strains prefer social over object stimuli, we revealed sex- and strain-specific differences in the behavioral dynamics. We then cross-bred C57BL/6J and BALB/c mice and demonstrated that the offspring of such cross-breeding exhibit a profile of social behavior which is different from both parental strains and depends on the specific combination of parental strains. Conclusions: We conclude that social behavior of laboratory mice is highly sex- and strain-specific and strongly depends on genetic factors.

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Deconstructing the contribution of sensory cues in social approach

Cited by 21 publications

References 27 publications

Reward and aversion encoding in the lateral habenula for innate and learned behaviours

Reward and aversion encoding in the lateral habenula for innate and learned behaviours

Neural Alterations in Interpersonal Distance (IPD) Cognition and Its Correlation with IPD Behavior: A Systematic Review

Sex-dependent parameters of social behavior show marked variations between distinct laboratory mouse strains and their mixed offspring

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