“…Our data support the conclusion of Stoyanovsky et al (55), that NO Ϫ forms hydroxyl radicals via a pathway independent of peroxynitrite. The mechanism offered by these authors appears plausible (Fig.…”
Section: Effect Of Nitric Oxide On Nitroxyl Anion-mediated Oxidation supporting
confidence: 92%
“…3E). In the absence of O 2 the yield of HO ⅐ radicals from Angeli's salt increased with increasing H ϩ concentration, in agreement with findings of Stoyanovsky et al (55). Furthermore, at atmospheric O 2 levels and in the presence of CO 2 , Angeli's salt was in regard to the O 2 -free solution only about half as effective to hydroxylate BA.…”
Section: Formation Of Peroxynitrite From Nitroxyl Anion-to Prove Whetsupporting
confidence: 90%
“…Recently, two research groups (55,56) reported that NO Ϫ released from Angeli's salt should generate hydroxyl radicals. As peroxynitrite is known to produce HO ⅐ radicals (57,58) with an efficiency of about 28% (9,59), it is unclear whether the HO ⅐ radicals detected by these groups may have derived exclusively from peroxynitrite.…”
Section: Formation Of Peroxynitrite From Nitroxyl Anion-to Prove Whetmentioning
“…Our data support the conclusion of Stoyanovsky et al (55), that NO Ϫ forms hydroxyl radicals via a pathway independent of peroxynitrite. The mechanism offered by these authors appears plausible (Fig.…”
Section: Effect Of Nitric Oxide On Nitroxyl Anion-mediated Oxidation supporting
confidence: 92%
“…3E). In the absence of O 2 the yield of HO ⅐ radicals from Angeli's salt increased with increasing H ϩ concentration, in agreement with findings of Stoyanovsky et al (55). Furthermore, at atmospheric O 2 levels and in the presence of CO 2 , Angeli's salt was in regard to the O 2 -free solution only about half as effective to hydroxylate BA.…”
Section: Formation Of Peroxynitrite From Nitroxyl Anion-to Prove Whetsupporting
confidence: 90%
“…Recently, two research groups (55,56) reported that NO Ϫ released from Angeli's salt should generate hydroxyl radicals. As peroxynitrite is known to produce HO ⅐ radicals (57,58) with an efficiency of about 28% (9,59), it is unclear whether the HO ⅐ radicals detected by these groups may have derived exclusively from peroxynitrite.…”
Section: Formation Of Peroxynitrite From Nitroxyl Anion-to Prove Whetmentioning
“…Mechanistically, these reactions were suggested to occur with the intermediate formation of [49][50][51][52][53] or (an isomer of) [54] peroxynitrite; [53,55] direct detection of the corresponding oxidizing species, however, has proven to be difficult. Irrespectively of the exact mechanism of these reaction(s), overproduction of HNO in tissues subjected to acidosis may lead to oxidative stress inasmuch as the ability of HNO to act as a pro-oxidant dramatically increases in acidic solutions (ref.…”
Section: Chemical Fate Of No• In Biological Systemsmentioning
confidence: 99%
“…Irrespectively of the exact mechanism of these reaction(s), overproduction of HNO in tissues subjected to acidosis may lead to oxidative stress inasmuch as the ability of HNO to act as a pro-oxidant dramatically increases in acidic solutions (ref. [51]; D. Stoyanovsky, personal communications). It could be generalized that metabolic hyperactivity or limited oxygen supply can cause a decrease of tissue pH.…”
Section: Chemical Fate Of No• In Biological Systemsmentioning
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