Decomposition of H2O2 by human lenses affected by cataract

Babizhaev, M. A.; Deev, A.I.; Vladimirov, Yu. A.; Deeva, Irina

doi:10.1007/bf00836191

Cited by 7 publications

(6 citation statements)

References 4 publications

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“…A function of ascorbic acid in lens and aqueous humour together with its particiaption in hydroxylation reactions might be linked with photochemical or biological oxidation mediated by superoxide anion radical and hydrogen peroxide generation in ocular tissues (Pirie 1965;Varma 1981;Varma et al 1979). The generation of the active oxygen forms in tissues of the anterior eye chamber might be accelerated as a result of reduced ability of the cataractous lens to decompose H,O, and to scavenge 0; Babizhayev et al 1986).…”

Section: Discussionmentioning

confidence: 99%

Lipid peroxidation in open‐angle glaucoma

Babizhayev

Bunin

1989

Acta Ophthalmologica

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UV-spectrophotometry and fluorescent analysis were used to study lipid extracts from lenses, aqueous humour and blocks containing trabecular and Schlemms canal tissues, obtained from 49 eyes of patients with primary open-angle glaucoma (POAG). Accumulation of the primary, secondary, and end products of lipid peroxidation (LPO) (diene and triene conjugates, Schiff's bases) was noted in the studied extracts. Significant differences in the levels of all the mentioned LPO products in comparison with the control were observed. The data may be considered as an evidence of LPO participation in destruction of the trabecule and Schlemm's canal in POAG.

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Section: Discussionmentioning

confidence: 99%

Lipid peroxidation in open‐angle glaucoma

Babizhayev

Bunin

1989

Acta Ophthalmologica

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“…The pathogenesis of degenerative, inflammatory, and infectious diseases involves free radical lipid peroxidation (FRLP) [1][2][3][4]. Chemical eye burns are accompanied by a decrease in the effectiveness of antioxidant protection and activation of FRLP.…”

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confidence: 99%

Effect of Natural Antioxidants on Antioxidant Activity and Lipid Peroxidation in Eye Tissue of Rabbits with Chemical Burns

Gakhramanov¹

2005

Bull Exp Biol Med

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Chemical eye burns were accompanied by free radical oxidation of lipids and dysfunction of the antioxidant protection system. The decrease in antioxidant activity of blood plasma reflected a generalized type of these processes. The concentration of thiobarbituric acid-reactive substances increased in blood plasma from rabbits with eye burns. The severity of disturbances was maximum at the stage of trophic disorders. Combination therapy with antioxidants and standard pharmaceuticals effectively inhibited lipid peroxidation in eye tissue of experimental animals.

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“…In cataractous eyes, aqueous and vitreous H,O, have been found as increased twice or three times; lipid peroxidation reactions are also reported as increased. Babizhaev (1986) (Babizhaev 1986). In an attempt to treat human cataract on this basis, Ahlrot-Westerlund & Norrby (1987) administered Se and vitamin E to an atopic patient with posterior subcapsular cataract and obtained favourable results.…”

Section: Discussionmentioning

confidence: 99%

Selenium concentrations in serum, lens and aqueous humour of patients with senile cataract

Karaküçük

Mirza

Ekinciler³

et al. 1995

Acta Ophthalmologica Scandinavica

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Selenium (Sc) is a trace element which incorporates into the selenoenzyme glutathion peroxidase. Cataractogenesis may be caused either by the excess or deficiency of this trace element. More recently, its potential of becoming a possible environmental pollutant has been emphasized. In an attempt to reveal the relationship of this element with cataractogenesis, we detected its level in 48 serum, 36 lens and 9 aqueous humour samples of 48 patients with senile cataract, comparing the results with appropriate controls. Selenium levels (mean +/- SD) of cataractous patients were found to be 0.28 +/- 0.04 microgram/ml (CI: 0.27 to 0.29 microgram/ml) in sera (controls: 0.32 +/- 0.04 microgram/ml; CI: 0.30 to 0.34 microgram/ml, p < 0.0001), 5.43 +/- 3.07 microgram/g dry weight (CI: 4.43 to 6.43 microgram/g dry weight) in lens (controls: 4.43 +/-2.53 microgram/g dry weight; CI: 2.78 to 6.08 microgram/g dry weight; p=0.374) and 0.19 +/- 0.06 microgram/ml (CI:0.15 to 0.23 microgram/ml) in aqueous humour samples (controls: 0.31 +/-0.12 microgram/ml; CI: 0.24 to 0.38 microgram/ml, p = 0.02). When patient subgroups were analyzed, serum Se levels were found to be 0.28 +/- 0.05 microgram/ml (CI: 0.26 to 0.30 microgram/ml in the nuclear cataract and 0.28 +/- 0.02 microgram/ml (CI: 0.27 to 0.30 microgram/ml) in the cortical cataract. Lens Se levels, on the other hand, were detected as 5.91 +/- 3.56 microgram/g dry weight (CI:4.49 to 7.33 microgram/g dry weight) in the nuclear cataract and 4.47 +/- 1.40 microgram/g dry weight (CI: 3.68 to 5.26 microgram/g dry weight) in the cortical cataract. It is anticipated that decreased Se in aqueous humour and sera of patients with senile cataract may reflect defective antioxidative defense systems which may lead to the formation of cataract.

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Decomposition of H2O2 by human lenses affected by cataract

Cited by 7 publications

References 4 publications

Lipid peroxidation in open‐angle glaucoma

Lipid peroxidation in open‐angle glaucoma

Effect of Natural Antioxidants on Antioxidant Activity and Lipid Peroxidation in Eye Tissue of Rabbits with Chemical Burns

Selenium concentrations in serum, lens and aqueous humour of patients with senile cataract

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