Decomposição dos Antirretrovirais Lamivudina e Zidovudina pelo Processo Fotofenton Assistido no Efluente de Indústria Farmoquímica

Souza, Sonia J. O.; Lobo, Tatiane M.; Sabino, Alline L. O.; Oliveira, Sérgio Botelho de; Costa, Orlene S.

doi:10.19142/rpq.v4i7.108

Cited by 7 publications

(8 citation statements)

References 2 publications

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“…Darunavir, lamivudine, and tenofovir have NOEC values below 10 mg/L, which are possible concentrations in a pharmaceutical effluent. Regarding concentration in industrial effluents, the work by Souza et al (2010) shows that the maximum concentrations of zidovudine and lamivudine, which are 6.29 mg/L and 3.22 mg/L respectively, do not come close to the NOECs for these substances.…”

Section: Resultsmentioning

confidence: 98%

“…High concentrations are expected in industrial effluent treatment plants. A study with real effluents from a zidovudine and lamivudine production plant found drug concentrations of 6.29 mg/L and 3.22 mg/L, respectively (Souza, et al, 2010). Therefore, even if a drug is classified as highly toxic and by the studies currently published, there is an indication that the values of environmental concentrations are low.…”

Section: Resultsmentioning

confidence: 99%

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Environmental elimination estimate and literature review of ecotoxicological aspects of the main widely used antiretrovirals in Brazil

Souza

Ribeiro

Soares

et al. 2022

RSD

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Objective: To estimate the consumption and quantity of unaltered antiretrivirals (ARV) eliminated into the environment and to carry out a literature research on aquatic ecotoxicological studies of ARV used in Brazil. Methodology: We requested from one of the ARV dispensing units in the city of Belo-Horizonte (BH) the amount of ARV dispensed in the years 2018-2019-2020. Considering the amount dispensed in 2020, the daily dose, and the elimination rate, the amount of drug in unchanged form in the environment was estimated. For entire municipality of BH and Brazil, we used epidemiological data were used regarding individuals using antiretroviral therapy (ART) in 2020, the proportion of people living with HIV using the main ART regimen, following the same estimation methodology used previously. Structured and individual searches were carried out for each ARV used in Brazil, relating it to ecotoxicology, through Google Scholar, National Center for Biotechnology Information and Scifinder, in addition to the use of the fass.se platform. Results: Four articles presented results of acute or chronic toxicity in ecotoxicological models involving ARV. Dolutegravir and efavirenz were found to be highly toxic in ecotoxicological models. In 2020, approximately 2,167kg of ARVs in unchanged form were released into the environment in BH. In Brazil it was 112,274kg. Conclusion: It is urgent to quantify the main ARV in water bodies. With these data together with ecotoxicological data it will be possible to establish risk criteria for possible measures to control or mitigate these contaminants in the environment, especially actions to improve wastewater/water treatment.

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Section: Resultsmentioning

confidence: 98%

Section: Resultsmentioning

confidence: 99%

Environmental elimination estimate and literature review of ecotoxicological aspects of the main widely used antiretrovirals in Brazil

Souza

Ribeiro

Soares

et al. 2022

RSD

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“…With regard to the photo-Fenton process, it managed to degrade the dye under study in the two radiations analyzed, especially with regard to the chromophore group (622 nm). In this AOP, ferrous ions act as electron donors for radical systems, while hydrogen peroxide decomposes into radicals and hydroxyl ions, causing the oxidation of ferrous ions to ferric ions(SOUZA et al 2010). Thus, the photo-Fenton/LED and photoperoxidation/UV-C systems went on to the optimization step of the variables [H2O2] and [Fe] (when applicable).…”

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confidence: 99%

Association of advanced oxidative and adsorptive processes for dye treatment in the sanitizer industry: kinetic, equilibrium and toxicity evaluation

Napoleão

Gonçalves

Neves

et al. 2023

REGET

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The presence of dyes in wastewater can cause several damages to the environment. Aiming at its removal, advanced oxidative processes (AOP) and adsorption (ADS) have been used. In this work, the removal of acid blue dye 80 (AA80) by AOP (photoperoxidation (PP) and photo-Fenton (PF)) and by ADS was evaluated, individually and combined. The use of the PP/UV-C system led to degradations of 72.7 and 83.8% for the λ of 334 and 622 nm, respectively. The PP/LED system did not degrade. For the PF process, > 90% degradation was obtained for both radiations. The [Fe] (1 mg.L-1) and [H2O2] (90 mg.L-1)were optimized for the PF/LED system. As for the PF/UV-C system, the optimal [H2O2] was 60 mg.L-1. The experimental data fit well with the Chan and Chu (2003) kinetic model with R2>0.94. The kinetic data showed a better fit to the pseudo-second order model (R2>0.90), while equilibrium was reached in 30 min with removal of 62.45 (λ=334 nm) and 83.22% (λ=622 nm), being well represented by the Langmuir and Sips models. Finally, the combined study promoted a 7% increase in AA80 removal, achieving an improvement in the final toxicity of the treated matrix when compared to isolated AOP systems.

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“…A eficiência do processo Fenton depende de alguns parâmetros operacionais: pH, concentrações de H2O2, Fe 2+ e do contaminante, temperatura, composição da matriz (presença de ânions -carbonato/bicarbonato, fosfato, cloreto, sulfato, etc), fonte de radiação e espécie de ferro (SOUZA et al, 2010;BRITO e SILVA, 2012;TROVÓ et al, 2013).…”

Section: Parâmetros Operacionais Do Processo Foto-fentonunclassified

Influência das espécies de ferro e matrizes aquosas na degradação do antibiótico cloranfenicol pelo processo foto-Fenton: identificação dos produtos de transformação

Ricardo¹

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Agradeço primeiro a Deus, por ter me ajudado até aqui, pois o temor dele é o princípio da sabedoria. À minha esposa Edna Argentina Alberto, aos meus irmãos Adérito José Ricardo, Ricardo Nelito e Audência de Cádima Romão, aos meus sogros Narciso Alberto e Argentina Luís Alberto e a todos familiares pelo apoio moral para a minha formação acadêmica e, especialmente à minha esposa por acreditar em mim e por ter aceito o desafio de submeter-se a momentos de solidão durante a minha formação no Brasil. Ao meu orientador Prof. Dr. Alam Gustavo Trovó, por aceitar orientar-me, pelo apoio moral e material para a minha integração no Brasil, pela oportunidade de realização de estágio de docência e, especialmente por tudo que me ensinou de forma didática, pautando pela paciência, dedicação e incentivo. À Profa. Dra. Raquel Maria Ferreira de Souza, pela nobre colaboração na análise dos espectros de massas e identificação de produtos de transformação formados durante a degradação do cloranfenicol. Aos membros da banca de qualificação, os Professores Doutores Alex Domingues Batista e Waldomiro Borges Neto, pelas valiosas contribuições para a melhoria da qualidade técnico-científica do presente trabalho. A todos os demais professores do Instituto de Química da Universidade Federal de Uberlândia que dedicaram o seu tempo dando contribuição para a minha formação acadêmica.

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Decomposição dos Antirretrovirais Lamivudina e Zidovudina pelo Processo Fotofenton Assistido no Efluente de Indústria Farmoquímica

Cited by 7 publications

References 2 publications

Environmental elimination estimate and literature review of ecotoxicological aspects of the main widely used antiretrovirals in Brazil

Environmental elimination estimate and literature review of ecotoxicological aspects of the main widely used antiretrovirals in Brazil

Association of advanced oxidative and adsorptive processes for dye treatment in the sanitizer industry: kinetic, equilibrium and toxicity evaluation

Influência das espécies de ferro e matrizes aquosas na degradação do antibiótico cloranfenicol pelo processo foto-Fenton: identificação dos produtos de transformação

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