Decoding the Role of Insulin-like Growth Factor 1 and Its Isoforms in Breast Cancer
Amalia Kotsifaki,
Sousanna Maroulaki,
Efthymios Karalexis
et al.
Abstract:Insulin-like Growth Factor-1 (IGF-1) is a crucial mitogenic factor with important functions in the mammary gland, mainly through its interaction with the IGF-1 receptor (IGF-1R). This interaction activates a complex signaling network that promotes cell proliferation, epithelial to mesenchymal transition (EMT) and inhibits apoptosis. Despite extensive research, the precise molecular pathways and intracellular mechanisms activated by IGF-1, in cancer, remain poorly understood. Recent evidence highlights the esse… Show more
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