Decoding the Mysteries of the Obturator Nerve

Mateusz, Mazurek; Oliwier, Pioterek; Mateusz, Drążyk; Dariya, Pozdnyakova; Oskar, Kozłowski; Victoria, Tarkowski; Jurand, Domański; Zygmunt, Domagała

doi:10.4103/jasi.jasi_122_23

Cited by 1 publication

(1 citation statement)

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“…A subset of articles was selected from each group for discussion in the review. Our team has experience in systematic reviews in morphological sciences and associated disciplines [124][125][126].…”

Section: Data Compilationmentioning

confidence: 99%

Most Relevant Genetic, Hormonal, and Environmental Factors in Ovarian Cancer Development – A Literature Review

Florczak,

Królikowska,

Mazurek

et al. 2024

Preprint

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Ovarian cancer (OC) represents a significant challenge in the realm of gynecological cancers, characterized by poor survival rates and complex etiology. In this review, we delve into the se-lected genetic, environmental, and hormonal factors underpinning OC development. We have reviewed scientific databases searching for ovarian cancer genetic and epigenetic factors. We have included studies based on their relevancy. As a result of exploring ovarian carcinogen-esis, this systematic review contains data collected from 126 various works. The role of prominent genetic players such as BRCA mutations, DNA repair mechanisms, un-derscores the intricate landscape of OC susceptibility. We explore Li-Fraumeni and Lynch syn-drome, which impart a heightened predisposition to OC development. Hormonal factors such as estrogen, progesterone, and androgens are also discussed. Environmental alterations, ranging from lifestyle influences on OC to microbiome dysbiosis and lifestyle factors such as obesity, al-cohol consumption, and physical activity intersect with genetic and epigenetic pathways, shaping the risk landscape for OC. Through a meticulous examination of current literature, this review provides a nuanced under-standing of the multifactorial nature of OC, emphasizing the need for holistic approaches to prevention, diagnosis, and treatment.

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Section: Data Compilationmentioning

confidence: 99%